DIABETES Alpha Cells Secrete Acetylcholine as a Non-Neuronal Paracrine Signal Priming Beta Cell Function in Humans Here researchers show that, in contrast to the case in mouse islets, cholinergic innervation of human islets is sparse. [Nat Med] The Impact of Hyperglycemia and the Presence of Encapsulated Islets on Oxygenation Within a Bioartificial Pancreas in the Presence of Mesenchymal Stem Cells in a Diabetic Wistar Rat Model This study investigates the potential of bone marrow versus adipose mesenchymal stem cells to potentiate the oxygenation of encapsulated islets in a subcutaneous bioartificial pancreas. [Biomaterials] Layer-By-Layer Co-Immobilization of Soluble Complement Receptor 1 and Heparin on Islets Here, human soluble form complement receptor 1 (sCR1) and heparin were co-immobilized onto the surfaces of islet cells. [Biomaterials] Islet-Like Cell Aggregates Generated from Human Adipose Tissue Derived Stem Cells Ameliorate Experimental Diabetes in Mice In the present study, researchers explore the potential of human adipose tissue derived adult stem cells to differentiate into functional islet like cell aggregates. [PLoS One] Liraglutide as Additional Treatment in Type 1 Diabetes The objective was to determine whether the addition of liraglutide to insulin in patients with type 1 diabetes leads to an improvement in glycemic control and diminished glycemic variability. [Eur J Endocrinol] PANCREATIC CANCER Angiopoietin-2 Drives Lymphatic Metastasis of Pancreatic Cancer As lymphangiogenesis has been implicated in stimulation of lymphatic metastasis by vascular endothelial growth factor-C (VEGF-C) and VEGF-D, researchers studied the effect of the angioregulatory growth factor angiopoietin-2 on pancreatic ductal adenocarcinoma progression. [FASEB J] Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways To assess the molecular mechanism(s) that are involved in the development of pancreatic ductal adenocarcinoma in the compound transgenic mice with activated K-ras and Ink4a/Arf deficiency, researchers used multiple methods, such as Real-time RT-PCR, western blotting assay, immunohistochemistry, MTT assay, invasion, EMSA and ELISA. [PLoS One] DNA Mismatch Repair Network Gene Polymorphism as a Susceptibility Factor for Pancreatic Cancer Researchers hypothesized that DNA mismatch repair gene variants are associated with risk of pancreatic cancer. [Mol Carcinog] Ethanol Differentially Regulates Snail Family of Transcription Factors and Invasion of Premalignant and Malignant Pancreatic Ductal Cells As ethanol is one of the major causes of pancreatitis, researchers examined the effect of ethanol on Snail family members in immortalized human pancreatic ductal epithelial cells and in pancreatic cancer cells. [J Cell Biochem] |