DIABETES A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, researchers have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice. [Science] Lowering Apolipoprotein CIII Delays Onset of Type 1 Diabetes Researchers have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apolipoprotein CIII was also increased in sera from prediabetic rats. [Proc Natl Acad Sci USA] Huntingtin-Interacting Protein 14 is a Type 1 Diabetes Candidate Protein Regulating Insulin Secretion and β-Cell Apoptosis To identify disease-causing genes in type 1 diabetes, researchers performed an in silico “phenome–interactome analysis” on a genome-wide linkage scan dataset. [Proc Natl Acad Sci USA] GABA Exerts Protective and Regenerative Effects on Islet Beta Cells and Reverses Diabetes Researchers report here that GABA exerts antidiabetic effects by acting on both the islet β-cells and immune system. [Proc Natl Acad Sci USA] PANCREATIC CANCER A Novel Therapeutic Strategy for Pancreatic Neoplasia Using a Novel RNAi Platform Targeting PDX-1 Bi-functional shRNA, a novel RNA interference effector platform targeting PDX-1 utilizing a systemic DOTAP-Cholesterol delivery vehicle, was studied in three mouse models of progressive pancreatic neoplasia. [Nature] Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence The results support the concept that anti-inflammatory treatment of people diagnosed with pancreatitis may reduce their risk of developing pancreatic ductal adenocarcinoma. [Cancer Cell] MicroRNA-148a is Down-Regulated in Human Pancreatic Ductal Adenocarcinomas and Regulates Cell Survival by Targeting CDC25B In the present study, researchers investigated the transcription status of miRNA-148a in human pancreatic ductal adenocarcinoma and its role in the regulation of the dual specificity protein phosphatase CDC25B. [Lab Invest] Armed and Targeted Measles Virus for Chemovirotherapy of Pancreatic Cancer For specific therapy of pancreatic cancer, researchers generated a fully retargeted measles virus that enters cells exclusively through the prostate stem cell antigen. [Cancer Gene Ther] |