DIABETES Multipotent Stem/Progenitor Cells in Human Biliary Tree Give Rise to Hepatocytes, Cholangiocytes and Pancreatic Islets Transplantation into quiescent livers of immunocompromised mice results in functional human hepatocytes and cholangiocytes, whereas if into fat pads of streptozocin-induced diabetic mice, results in functional islets secreting glucose-regulatable human C-peptide. [Hepatology] Modulation of Pancreatic Islets-Stress Axis by Hypothalamic Releasing Hormones and 11β-Hydroxysteroid Dehydrogenase Here, researchers demonstrate the expression of messenger RNA for corticotropin-releasing hormone (CRH) and CRH-receptor type 1 (CRHR1) and of protein for CRHR1 in rat and human pancreatic islets and rat insulinoma cells. [Proc Nat Acad Sci USA] Pancreatic β-Cell Raf-1 Is Required for Glucose Tolerance, Insulin Secretion, and Insulin 2 Transcription This work provides the first direct evidence that Raf-1 signaling is essential for the regulation of basal insulin transcription and the supply of releasable insulin in vivo. [FASEB J] Formation of Pancreatic Islets Involves Coordinated Expansion of Small Islets and Fission of Large Interconnected Islet-like Structures Investigators have carried out a comprehensive analysis of changes of islet size distribution in the intact mouse pancreas from birth to eight months, including mathematical modeling to quantify this dynamic biological process. [Biophys J] Ultrastructural Analysis, Zinc Transporters, Glucose Transporters and Hormones Expression in New World Primate (Callithrix jacchus) and Human Pancreatic Islets Ultrastructure, and gene expression of pancreatic islets and the recently described diabetes auto antigenic zinc transporters families in human, new world primates and pig pancreas were studied. [Gen Comp Endocrinol] PANCREATIC CANCER Deficiency of the Macrophage Growth Factor CSF-1 Disrupts Pancreatic Neuroendocrine Tumor Development Researchers show in this study that CD68+ macrophages positively correlate with tumor grade and liver metastasis in human pancreatic neuroendocrine tumors. [Oncogene] High Expression of Delta-Like Ligand 4 Predicts Poor Prognosis After Curative Resection for Pancreatic Cancer The aim was to determine whether high Delta-Like Ligand 4 expression is correlated with poor prognosis after curative resection for pancreatic ductal adenocarcinoma. [Ann Surg Oncol] Tumor-Infiltrating Neutrophils in Pancreatic Neoplasia In this study, the presence of tumor-infiltrating neutrophils within and/or adjacent to neoplastic cells was investigated in pancreatic neoplasms. [Mod Pathol] Semaphorin 4D, a Lymphocyte Semaphorin, Enhances Tumor Cell Motility Through Binding its Receptor, PlexinB1, in Pancreatic Cancer Here, researchers report a new signaling pathway that was found to mediate the enhanced tumor cell motility in pancreatic cancer. [Cancer Sci] |