DIABETES Rapamycin Toxicity in MIN6 Cells and Rat and Human Islets Is Mediated by the Inhibition of mTOR Complex 2 The primary objective of this study was to elucidate the molecular mechanism of rapamycin toxicity in beta cells. [Diabetologia] Abstract Ectopic Expression of Glucagon Receptor in Skeletal Muscles Improves Glucose Homeostasis in a Mouse Model of Diabetes Scientists aimed to study the effects of a ‘decoy receptor’ for circulating glucagon on modulating beta cell function and glucose homeostasis in mice by over-producing the glucagon receptor in skeletal muscles. [Diabetologia] Abstract Superior Beta Cell Proliferation, Function and Gene Expression in a Subpopulation of Rat Islets Identified by High Blood Perfusion This study tested the hypothesis that there is heterogeneity between islets with regard to beta cell proliferation, function and gene expression based on differences in their blood perfusion. [Diabetologia] Abstract Transient Overexpression of Cyclin D2/CDK4/GLP1 Genes Induces Proliferation and Differentiation of Adult Pancreatic Progenitors and Mediates Islet Regeneration Researchers hypothesized that gene therapy with cyclin D2/CDK4/GLP-1 plasmids targeted to the pancreas of STZ-treated rats by ultrasound-targeted microbubble destruction would force cell cycle re-entry of residual G0-phase islet cells into G1/S phase to regenerate β cells. [Cell Cycle] Abstract A New Enzyme Mixture to Increase the Yield and Transplant Rate of Autologous and Allogeneic Human Islet Products In this study, investigators evaluated eight different enzyme combinations in an attempt to improve islet yield. [Transplantation] Abstract Reversal of Diabetes by βTC3 Cells Encapsulated in Alginate Beads Generated by Emulsion and Internal Gelation Encapsulation of insulin-producing cells in alginate beads could improve the treatment of type 1 diabetes by reducing or eliminating the need for immunosuppression. Investigators have recently adapted an emulsion and internal gelation process to β-cell encapsulation. [J Biomed Mater Res B Appl Biomater] Abstract PANCREATIC CANCER Diabetes Aggravates Acute Pancreatitis and Inhibits Pancreas Regeneration in Mice The aim of this study was to evaluate if diabetes merely reflects the severity of pancreatitis or whether it can also aggravate the progression of this disease in a vicious circle. [Diabetologia] Abstract Plumbagin, a Plant Derived Natural Agent Inhibits the Growth of Pancreatic Cancer Cells In Vitro and In Vivo via Targeting EGFR, Stat3 and NF-κB Signaling Pathways Scientists present here that plumbagin, a quinoid constituent isolated from the roots of the medicinal plant Plumbago zeylanica L, inhibits the growth of pancreatic cancer cells in both in vitro and in vivo model systems. [Int J Cancer] Abstract Transient Receptor Potential Melastatin-Related 7 Channel Is Overexpressed in Human Pancreatic Ductal Adenocarcinomas and Regulates Human Pancreatic Cancer Cell Migration Results indicate that melastatin-related transient receptor potential 7 channel (TRPM7) is involved in the BxPC-3 cell migration via a Mg2+-dependent mechanism and may be a potential biomarker of poor prognosis of pancreatic ductal adenocarcinoma. [Int J Cancer] Abstract Identification of NME5 as a Contributor to Innate Resistance to Gemcitabine in Pancreatic Cancer Cells The limited therapeutic effect of gemcitabine on pancreatic cancer is largely attributed to pre-existing or acquired resistance of the tumor cells. This study aims to screen for candidate resistance-related gene(s) and to elucidate the underlying mechanisms. [FEBS J] Abstract |