Pancreatic Cell News Volume 3.07 | Feb 21 2012

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Here, researchers integrated type 1 diabetes genome-wide association studies data with protein-protein interactions to construct biological networks of relevance for disease. To prioritize and substantiate the networks, they also performed expressional profiling in human pancreatic islets exposed to proinflammatory cytokines. [Diabetes] Abstract

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca²⁺ Ions in Pancreatic β-Cells
Here investigators reveal, using both MIN6 and primary mouse β-cells, a unique mechanism behind carbohydrate-responsive element-binding protein (ChREBP) nuclear translocation. [Diabetes] Abstract

Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18
In order to test whether free fatty acids restrict β-cell proliferation in vivo, mice were intravenously infused with saline, Liposyn II, glucose, or both, continuously for 4 days. [Diabetes] Abstract

Islet Amyloid Polypeptide Triggers Limited Complement Activation and Binds Complement Inhibitor C4b-Binding Protein, which Enhances Fibril Formation
Aggregation and formation of islet amyloid polypeptide (IAPP)-amyloid plays a critical role in β-cell death in type 2 diabetic patients. Researchers investigated specific interactions between IAPP and complement factors. [J Biol Chem] Abstract

Comparative Impact on Islet Isolation and Transplant Outcome of the Preservation Solutions Institut Georges Lopez-1, University of Wisconsin, and Celsior
In this study, researchers assessed the impact of Institut Georges Lopez-1, University of Wisconsin, and Celsior solutions on islet isolation and transplant outcome. [Transplantation] Abstract

PANCREATIC CANCER

The Human GLP-1 Analog Liraglutide and the Pancreas: Evidence for the Absence of Structural Pancreatic Changes in Three Species
Scientists investigated whether liraglutide, the once-daily human glucagon-like peptide-1 (GLP-1) analog, induces pancreatitis in rats, mice, and monkeys. [Diabetes] Abstract

Phase I Study of Rigosertib, an Inhibitor of the Phosphatidylinositol 3-Kinase and Polo-Like Kinase 1 Pathways, Combined with Gemcitabine in Patients with Solid Tumors and Pancreatic Cancer
This phase I study aimed to determine the recommended phase II dose of the combination of rigosertib and gemcitabine in cancer patients. [Clin Cancer Res] Abstract

Radiation-Inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine
Here, investigators treated melanoma and pancreatic carcinoma in syngeneic mice with ionizing radiation combined with the poly(ADP-ribose) polymerase inhibitor veliparib to inhibit DNA repair and promote accelerated senescence. [Mol Ther] Abstract

Identification of Glycoprotein Markers for Pancreatic Cancer CD24⁺CD44⁺ Stem-Like Cells Using Nano LC-MS/MS and Tissue Microarray
Herein, the malignant phenotype of pancreatic cancer stem-like CD24⁺CD44⁺ cells was isolated from a human pancreatic carcinoma cell line (PANC-1), and demonstrated 4-fold increased invasion ability compared to CD24^–CD44⁺ cells. [J Proteome Res] Abstract

Long-Term Results of Adjuvant Gemcitabine Plus S-1 Chemotherapy After Surgical Resection for Pancreatic Carcinoma
This study evaluated long-term outcomes for patients who received adjuvant gemcitabine plus S-1 chemotherapy after resection for pancreatic carcinoma. [J Surg Oncol] Abstract

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientific Marketing Communications Specialist (STEMCELL Technologies Inc.)

Research Technologist (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Associate Professor – Stem Cell Biology and Diabetes (McEwen Centre for Regenerative Medicine)

PhD Scholarships – Ion Transport Proteins in Control of Cancer Cell Behavior (Copenhagen University, Faculty of Science)

PhD Student Positions – Stem Cell Differentiation and Cellular Reprogramming (University Hospital of Ulm)


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