DIABETES Serine/Threonine Protein Phosphatase 5 Regulates Glucose Homeostasis In Vivo and Apoptosis Signaling in Mouse Pancreatic Islets and Clonal MIN6 Cells Researchers tested the hypothesis that serine/threonine protein phosphatase 5 acts to suppress proapoptotic c-Jun N-terminal kinase signaling in beta cells. [Diabetologia] Abstract Delta Cell Secretory Responses to Insulin Secretagogues Are Not Mediated Indirectly by Insulin Scientists investigated whether delta cell secretory responses are indirectly regulated in a paracrine manner by insulin released from beta cells. [Diabetologia] Abstract Mechanism of Prostacyclin-Induced Potentiation of Glucose-Induced Insulin Secretion Researchers aimed to analyze the role of prostacyclin in β-cell function. [Endocrinology] Abstract Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells Researchers studied the potential effects of STX on pancreatic β-cell function. [PLoS One] Abstract PANCREATIC CANCER Comparing Human Pancreatic Cell Secretomes by In Vitro Aptamer Selection Identifies Cyclophilin B as a Candidate Pancreatic Cancer Biomarker The authors devised an in vitro positive/negative selection strategy to identify RNA ligands that could detect structural differences between the secretomes of pancreatic cancer and non-cancerous cells. [J Clin Invest] Abstract Molecular Profiling of Pancreatic Neuroendocrine Tumors in Sporadic and Von Hippel-Lindau Patients Researchers aimed to characterize, by molecular quantitative analysis, a panel of molecules implicated in the Von Hippel-Lindau (VHL) pathway and in tumor progression in the pancreatic neuroendocrine tumors of patients with VHL. [Clin Cancer Res] Abstract Perifosine-Mediated Akt Inhibition in Neuroendocrine Tumor Cells – Role of Specific Akt Isoforms Scientists examined the effect of Akt inhibition on neuroendocrine tumor cells of heterogeneous origin. [Endocr Relat Cancer] Abstract Delivery of Interferon Alpha Using a Novel Cox2-Controlled Adenovirus for Pancreatic Cancer Therapy Researchers designed a novel targeted adenovirus with replication restricted to cyclooxygenase 2 (Cox2)-overexpressing pancreatic ductal adenocarcinomas and hypothesize that the locally delivered therapeutic gene interferon alpha can augment oncolytic effects while minimizing systemic toxicity. [Surgery] Abstract The Bisphosphonate Incadronate Inhibits Intraperitoneal Dissemination in an In Vivo Pancreatic Cancer Model Scientists evaluated the ability of an aminobisphosphonate, incadronate, to inhibit the growth of disseminated pancreatic cancer in vivo. [Oncol Rep] Abstract |