DIABETES Expression of Endoplasmic Reticulum Stress Markers in the Islets of Patients with Type 1 Diabetes Islets from individuals with type 1 diabetes showed increased levels of C/EBP homologous protein and, at least for insulitis-positive and beta cell-containing islets, immunoglobulin heavy chain. X-box binding protein 1 expression was not, however, increased. [Diabetologia] Abstract The Regulation of Rasd1 Expression by Glucocorticoids and Prolactin Controls Peripartum Maternal Insulin Secretion Immunofluorescent staining demonstrated that Rasd1 is localized within pancreatic β-cells. Data indicate that the stimulation of Rasd1 expression by glucocorticoid at the end of pregnancy reverses the increased insulin secretion that occurs during pregnancy. Prolactin negatively regulates this pathway by inhibiting glucocorticoid receptor/signal transducer and activator of transcription 5b transcriptional activity on the Rasd1 gene. [Endocrinology] Abstract Agelaia MP-I: A Peptide Isolated from the Venom of the Social Wasp, Agelaia pallipes pallipes, Enhances Insulin Secretion in Mice Pancreatic Islets The insulin secretion of isolated pancreatic islets from adult Swiss mice was evaluated in the presence of synthetic Agelaia MP-I peptide, and some mechanisms of action of this peptide on endocrine pancreatic function were characterized. [Toxicon] Abstract Acute Hypoxia Induces Apoptosis of Pancreatic β-Cell by Activation of the Unfolded Protein Response and Upregulation of C/EBP Homologous Protein Researchers observed that pancreatic islets of type 2 db/db diabetic mice were more hypoxic than their counterpart in normoglycemic animals. This finding indicates that hypoxia-mediated apoptosis may occur in type 2 diabetes. [Cell Death Dis] Full Article PANCREATIC CANCER Immunohistochemical Characteristics and Malignant Progression of Hepatic Cystic Neoplasms in Comparison with Pancreatic Counterparts The immunohistochemical features of intraductal papillary neoplasm of the bile duct and hepatic mucinous cystic neoplasm were characterized and compared with those of similar pancreatic lesions, intraductal papillary mucinous neoplasm of the pancreas, and pancreatic mucinous cystic neoplasm and with those of other biliary cystic lesions, peribiliary cysts. [Hum Pathol] Abstract M2-Polarized Tumor-Associated Macrophage Infiltration of Regional Lymph Nodes Is Associated with Nodal Lymphangiogenesis and Occult Nodal Involvement in pN0 Pancreatic Cancer Researchers investigated the relationship of M2-polarized tumor-associated macrophage infiltration of the regional lymph nodes, nodal lymphangiogenesis, and occult nodal involvement in pN0 pancreatic cancer. [Pancreas] Abstract Solid-Pseudopapillary Tumor of the Pancreas: Clinical Features, Pathological Characteristics, and Origin Investigators aimed to study clinically pathological features and origin of solid-pseudopapillary tumor of pancreas. [J Surg Oncol] Abstract High Dose Glargine Alters the Expression Profiles of MicroRNAs in Pancreatic Cancer Cells Researchers investigated the effect of high dose glargine on the expression profiles of microRNAs in human pancreatic cancer cells. [World J Gastroenterol] Abstract Prognostic Significance of ATM and Cyclin B1 in Pancreatic Neuroendocrine Tumor The authors evaluated the clinical and prognostic significance of ataxia telangiectasia mutated kinase (ATM) and cyclin B1 in patients with pancreatic neuroendocrine tumors. [Tumor Biol] Abstract |