DIABETES Inactivation of the Dual Bmp/Wnt Inhibitor, Sostdc1, Enhances Pancreatic Islet Function Investigators found the dual Bmp and Wnt antagonist Sostdc1 to be up-regulated in a mouse model of islet dysmorphogenesis and non-immune mediated, lean diabetes. Because Bmp signaling has been proposed to enhance β cell function, they evaluated the role of Sostdc1 in adult islet function using animals in which Sostdc1 was globally deleted. [Am J Physiol Endocrinol Metab] Abstract Impaired Autophagic Function in Rat Islets with Aging Results suggest that β-cell and autophagic function in islets decline simultaneously with increasing age in Wistar rats, and that impaired autophagy in the islets of older rats may cause accumulation of misfolded and aggregated proteins and reduce the removal of abnormal mitochondria in β-cells, leading to reduced β-cell function. [Age] Abstract Calcium-Sensing Receptor Activation Increases Cell-Cell Adhesion and β-Cell Function Data suggest that activation of the calcium-sensing receptor increases E-cadherin mediated functional tethering between β-cells and increases expression of L-type VDCC and secretagogue-evoked changes in [Ca2+]i. [Cell Physiol Biochem] Abstract Increased Secretion of Insulin and Proliferation of Islet β-Cells in Rats with Mesenteric Lymph Duct Ligation Researchers investigated the influence of ligation of the mesenteric lymph duct on glucose metabolism and islet β-cells in rats. [Biochem Biophys Res Commun] Abstract PANCREATIC CANCER NFATc3 Regulates Trypsinogen Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice Researchers explored the involvement of the calcium- and calcineurin-dependent transcription factor nuclear factor of activated T-cells (NFAT) in development of acute pancreatitis in mice. [Gastroenterology] Abstract Activation of Soluble Adenylyl Cyclase Protects against Secretagogue Stimulated Zymogen Activation in Rat Pancreatic Acinar Cells Data suggest that activation of soluble adenylyl cyclase in the pancreatic acinar cell has a protective effect and reduces the pathologic activation of proteases during pancreatitis. [PLoS One] Full Article Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis Researchers reported that glycogen synthase kinase-3 inhibition using the pharmacologic agent AR-18, enhanced tumor necrosis factor-related apoptosis inducing ligand (TRAIL) sensitivity in a range of pancreatic and prostate cancer cell lines. [PLoS One] Full Article Attenuation of Reactive Oxygen Species by Antioxidants Suppresses Hypoxia-Induced Epithelial-Mesenchymal Transition and Metastasis of Pancreatic Cancer Cells Scientists investigated the role of reactive oxygen species (ROS) in hypoxia-induced epithelial-mesenchymal transition (EMT) and whether attenuation of ROS by antioxidants suppresses hypoxia-induced EMT and metastasis of human pancreatic cancer cells in a xenograft nude mouse model. [Clin Exp Metastasis] Abstract Expression of Cancer Stem Cell Markers in Pancreatic Intraepithelial Neoplasias and Pancreatic Ductal Adenocarcinomas Investigators examined the correlation between pancreatic intraepithelial neoplasias and cancer stem cell markers including CD24, CD44, CD133, CXCR4, ESA and nestin using immunohistochemical analysis. [Int J Oncol] Abstract |