Pancreatic Cell News Volume 3.34 | Aug 28 2012

DIABETES

Histone H3K27me3 Demethylases KDM6A and KDM6B Modulate Definitive Endoderm Differentiation from Human ESCs by Regulating WNT Signaling Pathway
Researchers showed that the H3K27me3 demethylases KDM6A and KDM6B play an important role in endoderm differentiation from human ESCs. [Cell Res] Abstract

TCF7L2 rs7903146 Impairs Islet Function and Morphology in Non-Diabetic Individuals
Investigators studied the impact of the transcription factor 7-like 2 (TCF7L2) type-2-diabetes-associated rs7903146 T allele on biological function and morphology of human pancreatic islets. [Diabetologia] Abstract

The Mitochondrial Atp8 Mutation Induces Mitochondrial Reactive Oxygen Species Generation, Secretory Dysfunction, and β-Cell Mass Adaptation in Conplastic B6-mt^FVB Mice
Researchers used conplastic mouse strains to characterize the impact of a mitochondrial DNA mutation in the Atp8 gene on β-cell function, reactive oxygen species generation, β-cell mass, and glucose metabolism in response to a high-fat diet. [Endocrinology] Abstract

Mechanism and Regulation of Vitamin B2 (Riboflavin) Uptake by Mouse and Human Pancreatic Beta Cells/Islets: Physiological and Molecular Aspects
Investigators addressed the mechanism of riboflavin uptake by pancreatic beta cells and how the process is regulated using mouse-derived pancreatic beta-TC-6 cells, and freshly isolated primary mouse and human pancreatic islets. [Am J Physiol Gastrointest Liver Physiol] Abstract

PANCREATIC CANCER

Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis
Investigators showed that intracellular sensor NOD1  participates in the induction of a noninfectious pancreatitis via its response to commensal organisms. [Immunity] Abstract

MyD88 Inhibition Amplifies Dendritic Cell Capacity to Promote Pancreatic Carcinogenesis via Th2 Cells
Because TLR4 ligation can exacerbate pancreatic inflammation, researchers hypothesized that TLR4 activation drives pancreatic carcinogenesis. Studies showed that lipopolysaccharide accelerates pancreatic tumorigenesis, whereas TLR4 inhibition is protective. [J Exp Med] Abstract

Single Domain Antibody Against Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) Inhibits Proliferation, Migration, Invasion and Angiogenesis of Pancreatic Cancer Cells
Researchers tested a single domain antibody (sdAb) targeting CEACAM6, 2A3 and a fragment crystallizable conjugated version of this sdAb, to determine how they affect the pancreatic cancer cell line BxPC3. [Eur J Cancer] Abstract

HOXB7 Promotes Invasion and Predicts Survival in Pancreatic Adenocarcinoma
Scientists assessed the impact of HOXB7 on cell proliferation, growth, and invasion by knockdown and overexpression in pancreatic ductal adenocarcinoma cell lines. [Cancer] Abstract

Inhibition of Hedgehog Signaling Depresses Self-Renewal of Pancreatic Cancer Stem Cells and Reverses Chemoresistance
To identify pancreatic cancer stem cells, investigators cultured tumorspheres derived from the PANC-1 pancreatic cancer cell line under a floating-culture system. [Int J Oncol] Abstract

Transgenomic Is Awarded NIH STTR Grant for Pancreatic Cancer Research
Transgenomic, Inc. announced it has been awarded a $100,000 Small Business Technology Transfer Program (STTR) Phase I Grant by the National Institutes of Health’s (NIH) National Center For Advancing Translational Sciences. [Transgenomic, Inc.] Press Release

Anne-Marie Duliege Appointed to Governing Board of California’s Stem Cell Agency
Anne-Marie Duliege, Chief Medical Officer of Affymax Inc., has been appointed to the Independent Citizens Oversight Committee, the governing board of California’s stem cell agency, and the California Institute for Regenerative Medicine. [The California Institute for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

National Health Service (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Clinical Investigator – Biomedical Research Program (Weill Cornell Medical College)

Postdoctoral Research Position (University Lille 2 France)

Postdoctoral Position – Cancer Therapeutics (Massachusetts General Hospital)

Postdoctoral Position – Dysfunction in Diabetes (University of Oxford)

Postdoctoral Position – Beta Cell Biology and Translational Research (University of California, Los Angeles)

Postdoctoral Position – Epigenetics and Diabetes (Weill Cornell Medical College in Qatar)

Research Associate – Quality Assurance (University of California)


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