| PUBLICATIONS (Ranked by impact factor of the journal) | DIABETES Lysine 63-Linked Ubiquitination Modulates Mixed Lineage Kinase-3 Interaction with JIP1 Scaffold protein in Cytokine-Induced Pancreatic Beta Cell Death In an effort to identify mechanisms that regulate mixed lineage kinase-3 (MLK3) activity in beta cells, scientists discovered that IL-1β stimulates lysine 63-linked ubiquitination of MLK3 via a conserved, TRAF6-binding peptapeptide motif in the catalytic domain of the kinase. [J Biol Chem] Abstract | Full Article Susceptibility to Fatty Acid-Induced β-Cell Dysfunction Is Enhanced in Prediabetic Diabetes-Prone BioBreeding Rats: A Potential Link between β-Cell Lipotoxicity and Islet Inflammation The authors examined the effects of prolonged free fatty acids elevation on β-cell secretory function in the prediabetic diabetes-prone BioBreeding rat, its diabetes-resistant BioBreeding control, and normal Wistar-Furth rats. [Endocrinology] Abstract N-Acyl Taurines Trigger Insulin Secretion by Increasing Calcium Flux in Pancreatic β-Cells Researchers discovered that treatment of pancreatic β-cell lines and rat islet cell lines with N-acyl taurines induced a high frequency of calcium oscillations in these cells. [Biochem Biophys Res Commun] Abstract Inhibition of Insulin Secretion from Rat Pancreatic Islets by Dexmedetomidine and Medetomidine, Two Sedatives Frequently Used in Clinical Settings Investigators aimed to determine whether dexmedetomidine and medetomidine, α2-adrenergic agonists clinically used as sedatives, influence insulin secretion from rat pancreatic islets. [Endocr J] Abstract Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis Investigators showed that progenitor cells forming the ducts of the embryonic pancreas express planar cell polarity (PCP) proteins and exhibit an active PCP pathway. Loss of function of the two PCP core components Celsr2 and Celsr3 shows that they control the differentiation of endocrine cells from polarized progenitors, with a prevalent effect on insulin-producing beta cells. [Cell Rep] Full Article | Graphical Abstract PANCREATIC CANCER MiR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1 Studies revealed that AMPKα1 might be the direct target gene of microRNA (miR)-148b, and overexpressed AMPKα1 inversely correlated with miR-148b in pancreatic cancer. Silencing of AMPKα1 with RNAi inhibited the growth of pancreatic cancer cells in vitro and in vivo, and also induced apoptosis, cell cycle arrest and inhibited invasion of cancer cells, which is consistent with the effects of miR-148b overexpression. [Mol Cancer Ther] Abstract Monogalactosyl Diacylglycerol, a Replicative DNA Polymerase Inhibitor, from Spinach Enhances the Anti-Cell Proliferation Effect of Gemcitabine in Human Pancreatic Cancer Cells Scientists discovered that in cell growth suppression by gemcitabine (GEM), pre-addition of monogalactosyl diacylglycerol (MGDG) significantly enhanced cell proliferation suppression, and the combination of these compounds was found to induce apoptosis. In contrast, GEM-treated cells followed by MGDG addition did not influence cell growth. [Biochim Biophys Acta] Abstract Cucurmosin Kills Human Pancreatic Cancer SW-1990 Cells In Vitro and In Vivo The authors investigated the effect of cucurmosin on proliferation inhibition in the human pancreatic cancer cell line SW-1990 in vitro and in vivo. [Anticancer Agents Med Chem] Abstract Metformin Inhibition of mTORC1 Activation, DNA Synthesis and Proliferation in Pancreatic Cancer Cells: Dependence on Glucose Concentration and Role of AMPK Researchers demonstrated that the potency of metformin induced AMPK activation was dramatically enhanced in human pancreatic ductal adenocarcinoma cells PANC-1 and MiaPaCa-2 cultured in medium containing physiological concentrations of glucose (5 mM), as compared with parallel cultures in medium with glucose at 25 mM. [Biochem Biophys Res Commun] Abstract |
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