| PUBLICATIONS (Ranked by impact factor of the journal) | DIABETES Islet α, β, and δ Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily with the Islet-1 Transcription Factor The islet-enriched pattern of Ldb1 was similar to pan-endocrine cell-expressed Islet-1 (Isl1), was demonstrated to be the primary Lin11-Isl1-Mec3-homeodomain transcription factor in developing and adult islet cells. [Diabetes] Abstract Intrapatient Variations in Type 1 Diabetes-Specific iPS Cell Differentiation into Insulin-Producing Cells From individual patients with type 1 diabetes, multiple human induced pluripotent stem (iPS) clones were produced and prospectively screened using a battery of developmental markers to assess respective differentiation propensity and proficiency in yielding functional insulin-producing progeny. [Mol Ther] Abstract Pharmacological Reduction of NEFA Restores the Efficacy of Incretin-Based Therapies through GLP-1 Receptor Signaling in the Beta Cell in Mouse Models of Diabetes Researchers investigated the effects of NEFA on incretin receptor signaling and examined the glucose-lowering efficacy of incretin-based drugs in combination with the lipid-lowering agent bezafibrate. Beta cell lines and mouse islets were used to examine glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide receptor signaling. [Diabetologia] Full Article Mitogen-Inducible Gene 6 Triggers Apoptosis and Exacerbates Endoplasmic Reticulum Stress-Induced β-Cell Death The authors used Mitogen-inducible gene 6 (Mig6) heterozygous knockout mice to study the role of Mig6 in regulating β-cell proliferation and survival. [Mol Endocrinol] Abstract Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic β-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation Scientists investigated the mechanism by which Trefoil factor 2 (TFF2) enhances pancreatic β-cell proliferation. The effects of TFF2 on cell proliferation were evaluated in INS-1 cells, MIN6 cells, and mouse islets using an adenovirus vector containing TFF2 or a recombinant TFF2 peptide. [Endocrinology] Abstract PANCREATIC CANCER Small-Molecule Inhibitors of the Cystic Fibrosis Transmembrane Conductance Regulator Increase Pancreatic Endocrine Cell Development in Rat and Mouse The authors aimed to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. In vitro experiments were performed using fetal pancreatic explants from rats and mice. They examined the actions on pancreatic cell development of glibenclamide, a sulfonylurea derivative, and glycine hydrazide, a small-molecule inhibitor of cystic fibrosis transmembrane conductance regulator. [Diabetologia] Abstract | Full Article Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer Researchers demonstrated that Plk1 phosphorylation of Orc2 and Hbo1 mediates the resistance to gemcitabine. They showed that the level of Plk1 expression positively correlates with gemcitabine resistance in both pancreatic cancer cells and xenograft tumors. [Mol Cancer Ther] Abstract GANT-61 Inhibits Pancreatic Cancer Stem Cell Growth In Vitro and in NOD/SCID/IL2R γ Null Mice Xenograft Researchers aimed to examine the molecular mechanisms by which GANT-61 (Gli transcription factor inhibitor) regulates stem cell characteristics and tumor growth. Effects of GANT-61 on cancer stem cells viability, spheroid formation, apoptosis, DNA-binding and transcriptional activities, and epithelial-mesenchymal transition were measured. [Cancer Lett] Abstract Salvianolic Acid B Inhibits the Amyloid Formation of Human Islet Amyloid Polypeptide and Protects Pancreatic Beta-Cells against Cytotoxicity Investigators tested whether salvianolic acid B (SalB) has any effect on the amyloidogenicity of human islet amyloid polypeptide (hIAPP). Their results clearly suggest that SalB can significantly inhibit the formation of hIAPP amyloid and disaggregate hIAPP fibrils. [Proteins] Abstract |
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