| REVIEWS | Generating Insulin-Producing Cells for Diabetic Therapy: Existing Strategies and New Development Since the initial induction of insulin-producing cells from embryonic stem (ES) cells in 1999, several strategies and alternative cell sources have been developed to generate β-like cells, including direct differentiation from ES cells or induced pluripotent stem cells, proliferation of existing adult β-cells, and reprogramming of non-pancreatic adult stem/mature cells or pancreatic non-β-cells to β-like-cells. The authors briefly review the most relevant studies for each strategy, and discuss the comparative merits and drawbacks. [Ageing Res Rev] Abstract |
|
|
|