DIABETES Nov/Ccn3, a Novel Transcriptional Target of FoxO1, Impairs Pancreatic β-Cell Function Investigators report the characterization of Nov/Ccn3 as a novel transcriptional target of FoxO1 in pancreatic β-cells. Their functional studies reveal that CCN3 impairs β-cell proliferation concomitantly with a reduction in cAMP levels. [PLoS One] Full Article Smad Signaling Pathways Regulate Pancreatic Endocrine Development Researchers found that transforming growth factor-beta (TGF-β) superfamily signaling, which has been implicated in many developmental processes, plays a key role in regulating pancreatic endocrine maturation and development. Specifically, the intracellular mediators of TGF-β signaling, smad2 and smad3, along with their inhibitor smad7, appear to mediate this process. [Dev Biol] Abstract Impaired Pancreatic Beta Cell Function by Chronic Intermittent Hypoxia Researchers investigated pancreatic beta cell function in C57BL6 mice exposed to 30 days of chronic intermittent hypoxia (CIH). Pancreatic beta cell morphology was unaltered in CIH exposed mice. Insulin content was decreased in CIH exposed beta cells, and this effect was associated with increased pro-insulin levels. [Exp Physiol] Abstract Increased Susceptibility to Streptozotocin and Impeded Regeneration Capacity of Beta-Cells in Adult Offspring of Malnourished Rats Scientists determined whether early malnutrition influences the vulnerability and the regeneration capacity of beta-cells after streptozotocin (STZ) damage at adulthood. Although control and low protein rats had equivalent pancreatic insulin content and beta-cell volume density at d34, hyperglycemia appeared earlier and was more dramatic in low protein than in control rats. STZ treatment increased beta-cell proliferation similarly in both groups. [Acta Physiol] Abstract B-Cell Translocation Gene 2 Positively Regulates GLP-1-Stimulated Insulin Secretion via Induction of PDX-1 in Pancreatic β-Cells Researchers demonstrated that B-cell translocation gene 2 is a crucial regulator in glucagon-like peptide-1 (GLP-1)-induced insulin gene expression and insulin secretion via upregulation of pancreatic duodenal homeobox-1 (PDX-1) in pancreatic β-cells. [Exp Mol Med] Full Article PANCREATIC CANCER Novel Curcumin Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment The authors evaluated the in vitro and in vivo therapeutic efficacy of a novel curcumin loaded magnetic nanoparticle (MNP-CUR) formulation in pancreatic cancer. Human pancreatic cancer cells exhibited efficient internalization of the MNP-CUR formulation in a dose dependent manner. [Mol Cancer Ther] Abstract PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer Scientists evaluated the therapeutic potential of PG545, an angiogenesis and heparanase inhibitor, in experimental pancreatic ductal adenocarcinoma. PG545 inhibited the proliferation, migration and colony formation of pancreatic cancer cells in vitro at pharmacologically relevant concentrations. [Mol Cancer Ther] Abstract Modulation of Pancreatic Tumor Potential by Overexpression of Protein Kinase C [Beta]1 PANC1-protein kinase C (PKC)[beta]1 and control cells were analyzed both in vitro and in vivo. PANC1-PKC[beta]1 cells displayed a lower growth capacity associated with the down-regulation of the MEK/ERK pathway and cyclin expression. [Pancreas] Abstract L-Arginine-NO-cGMP Signaling Pathway in Pancreatitis Scientists investigated the co-expression of nitric oxide (NO) synthase with enzymes involved in regulation of NO signaling in the normal human pancreas and in pancreatitis. They found that the whole NO signaling machinery was up-regulated in pancreatitis, especially within the exocrine compartment. [Sci Rep] Full Article Mesothelin Binding to Cancer Antigen 125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation Using sophisticated bioengineering and molecular biology tools, scientists report that the binding of mesothelin (MSLN) to mucin-16 (MUC16) markedly enhances pancreatic cancer (PC) cell motility and invasion via the selective induction of matrix metalloproteinase (MMP)-7. MSLN-mediated MMP-7 upregulation in MUC16-expressing PC cells occurs via a p38 MAPK-dependent pathway. [Sci Rep] Full Article |