Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but not Adult, Pancreatic Islets Inactivation of vascular endothelial growth factor-A early in development dramatically reduced pancreatic and islet vascularization, leading to reduced ß-cell proliferation in both developing and adult islets and, ultimately, reduced ß-cell mass and impaired glucose clearance. [Diabetes] Abstract Enrichment of Human Embryonic Stem Cell-Derived NKX6.1-Expressing Pancreatic Progenitor Cells Accelerates the Maturation of Insulin-Secreting Cells In Vivo The relative contributions of NKX6.1-negative versus NKX6.1-positive cell fractions to the maturation of functional ß-cells remain unclear. To address this scientists generated two distinct pancreatic progenitor cell populations using modified differentiation protocols. [Stem Cells] Abstract Bach1 Deficiency Protects Pancreatic ß-Cells from Oxidative Stress Injury The role of BTB and CNC homology 1 (Bach1) in the development of diabetes is unclear. Heme oxygenase-1 expression in the liver, white adipose tissue and pancreatic islets was markedly up-regulated in Bach1-deficient mice. [Am J Physiol Endocrinol Metab] Abstract Extracellular Matrix Composition Significantly Influences Pancreatic Stellate Cell (PSC) Gene Expression Pattern: Role of Transgelin in PSC Function In vitro protocols examining PSC biology have usually involved PSCs cultured on plastic, a non-physiological surface. Culture of PSCs on different matrices significantly affected their gene expression pattern. [Am J Physiol Gastrointest Liver Physiol] Abstract Proteomic Analysis of Apoptotic and Oncotic Pancreatic Acinar AR42J Cells Treated with Caerulein Scientists determined the differentially expressed proteins in the pancreatic acinar cells undergoing apoptosis and oncosis stimulated with caerulein to explore different cell death processes of the acinar cell. [Mol Cell Biochem] Abstract PANCREATIC CANCER miR-99b-Targeted mTOR Induction Contributes to Irradiation Resistance in Pancreatic Cancer Ionizing radiation promoted mTOR expression and activation in pancreatic cancer cells through reducing microRNA (miR)-99b expression, which negatively regulated mTOR. [Mol Cancer] Abstract | Full Article Knockdown of Oct4 and Nanog Expression Inhibits the Stemness of Pancreatic Cancer Cells Double knockdown of Oct4 and Nanog demonstrated that Oct4 and Nanog significantly reduced proliferation, migration, invasion, chemoresistance, and tumorigenesis of pancreatic cancer stem cells in vitro and in vivo. [Cancer Lett] Abstract Cooperation among Numb, MDM2 and p53 in the Development and Progression of Pancreatic Cancer Researchers studied the expression of Numb, MDM2 and p53 for clinical significance in pancreatic cancer (PC) and their functional relationship in regulating biological behaviors of PC cells. [Cell Tissue Res] Abstract Tumor Protein D52 Controls Trafficking of an Apical Endolysosomal Secretory Pathway in Pancreatic Acinar Cells Researchers showed that tumor protein D52 is highly expressed in endosomal compartments following pancreatic acinar stimulation and regulates apical exocytosis of an apically directed endolysosomal compartment. [Am J Physiol Gastrointest Liver Physiol] Abstract Structure-Activity Relationship (SAR) of Withanolides to Inhibit Hsp90 for Its Activity in Pancreatic Cancer Cells Researchers investigated the SAR of withanolides for their inhibition of Hsp90 and anti-proliferative activities in pancreatic cancer cells. [Invest New Drugs] Abstract |