TGF-Beta Superfamily Member Nodal Stimulates Human Beta Cell Proliferation while Maintaining Cellular Viability Scientists investigated the effects of Nodal and Cripto on human beta cell proliferation, differentiation, and viability. In human pancreas and isolated human islets, they observed Nodal mRNA and protein expression, with protein expression observed in beta and alpha cells. [Endocrinology] Abstract Testosterone Protects against Glucotoxicity Induced Apoptosis of Pancreatic ß-Cells (INS-1) and Male Mouse Pancreatic Islets Investigators examined the anti-apoptotic mechanism of testosterone in pancreatic ß cells cultured in high-glucose medium. [Endocrinology] Abstract Improved MIN6 ß-Cell Function on Self-Assembled Peptide Amphiphile Nanomatrix Inscribed with Extracellular Matrix-Derived Cell Adhesive Ligands Compared to control groups cultured on biologically inert substrates, MIN6 ß-cells cultured on peptide amphiphiles functionalized with YIGSR and RGDS cell adhesive ligands exhibit elevated insulin secretion in responses to glucose and also form ß-cell clusters. [Macromol Biosci] Abstract Characterization of FKGK18 as Inhibitor of Group VIA Ca2+-Independent Phospholipase A2 (iPLA2ß): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes Recently, a fluoroketone-based compound (FKGK18) was described as a potent inhibitor of iPLA2ß. Here scientists characterized its inhibitory profile in beta-cells. [PLoS One] Full Article Oxidative Stress Plays a Role in High Glucose-Induced Activation of Pancreatic Stellate Cells Pancreatic stellate cells (PSCs) were isolated and cultured from Sprague Dawley rats, and treated with high glucose for 72 hours. High glucose increased the production of reactive oxygen species. When treated with high glucose, freshly isolated PSCs exhibited myofibroblastic transformation. [Biochem Biophys Res Commun] Abstract PANCREATIC CANCER Reduced Expression of Bone Morphogenetic Protein Receptor IA in Pancreatic Cancer Is Associated with a Poor Prognosis In vitro inactivation of SMAD4-dependent bone morphogenetic protein (BMP) signaling increases proliferation and invasion of pancreatic cancer cells, whereas inactivation of BMP signaling in SMAD4-negative cell does not change the proliferation and invasion or leads to an opposite effect. [Brit J Cancer] Abstract Moringa Oleifera Aqueous Leaf Extract Down-Regulates Nuclear Factor-KappaB and Increases Cytotoxic Effect of Chemotherapy in Pancreatic Cancer Cells Researchers investigated the effect of aqueous Moringa Oleifera leaf extract on cultured human pancreatic cancer cells – Panc-1, p34, and COLO 357, and whether it can potentiate the effect of cisplatin chemotherapy on these cells. [BMC Complement Altern Med] Abstract | Full Article The Effect of Simvastatin on Lipid Droplets Accumulation in Human Embryonic Kidney Cells and Pancreatic Cancer Cells Scientists assessed in non-malignant as well as cancer cells the impact of simvastatin on the amount of cytosolic lipid droplets implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. [Lipids Health Dis] Abstract MiR-148a Regulates the Growth and Apoptosis in Pancreatic Cancer by Targeting CCKBR and Bcl-2 Researchers showed significant downregulation of miR-148a in 28 pancreatic cancer tissue samples and five pancreatic cancer cell lines, compared with their non-tumor counterparts by qRT-PCR. [Tumor Biol] Abstract miR-143 Decreases COX-2 mRNA Stability and Expression in Pancreatic Cancer Cells Pancreatic cancer tissues and cells exhibit decreased microRNAs (miRNA), elevated cyclooxygenase (COX)-2 and increased prostaglandin E2 resulting in increased cancer growth and metastases. [Biochem Biophys Res Commun] Abstract |