DIABETES & PANCREATITIS Soluble Factors Secreted by T-Cells Promote β-Cell Proliferation Researchers report that islets exhibiting insulitis manifested proliferation of β-cells which positively correlated with the extent of lymphocyte infiltration. [Diabetes] Abstract | Press Release A Smad Signaling Network Regulates Islet Cell Proliferation Recently, beta cell de-differentiation has been shown to be an important contributory mechanism to beta cell failure. Here scientists tie together these two pathways by showing that a network of intracellular TGF-beta regulators, smads 7, 2, and 3 control beta cell proliferation after beta cell loss, and specifically smad7 is necessary for that beta cell proliferation. [Diabetes] Abstract Necro-Inflammatory Response of Pancreatic Acinar Cells in the Pathogenesis of Acute Alcoholic Pancreatitis Alcohol enhanced lipopolysaccharide (LPS)-induced TNFα expression, whereas blockade of LPS signaling diminished TNFα production in vitro, indicating that the response of pancreatic acinar cells to LPS is similar to that of immune cells. [Cell Death Dis] Full Article The PARK2 Gene Is Involved in the Maintenance of Pancreatic β-Cell Functions Related to Insulin Production and Secretion Downregulation of the Park2 gene in rat INS-1 β-cells resulted in a significant decrease in the glucose-stimulated insulin secretion, intracellular insulin gene expression, and intracellular ATP level. [Mol Cell Endocrinol] Abstract Specific Transduction and Labeling of Pancreatic Ducts by Targeted Recombinant Viral Infusion into Mouse Pancreatic Ducts Researchers achieved a high pancreatic duct labeling efficiency using a recombinant adeno-associated virus with a duct-specific sox9 promoter infused into the mouse common biliary/pancreatic duct. [Lab Invest] Abstract Microbead-Based Biomimetic Synthetic Neighbors Enhance Survival and Function of Rat Pancreatic β-Cells Researchers obtained sustained maintenance of β-cell function in vitro enhanced cell viability from the few days usually observed in 2D culture to periods exceeding three weeks, with enhanced β-cell stability and insulin production. [Sci Rep] Full Article PANCREATIC CANCER MicroRNA-10b Enhances Pancreatic Cancer Cell Invasion by Suppressing TIP30 Expression and Promoting EGF and TGF-β Actions Scientists determined that plasma microRNA-10b (miR-10b) levels are significantly increased in pancreatic ductal adenocarcinoma patients by comparison with normal controls. By gene profiling, they identified potential targets downregulated by miR-10b, including Tat-interacting protein 30 (TIP30). [Oncogene] Full Article Targeting and Cytotoxicity of SapC-DOPS Nanovesicles in Pancreatic Cancer Researchers observed that nanovesicles selectively killed human pancreatic cancer cells in vitro by inducing apoptotic death, whereas untransformed cells remained unaffected. This in vitro cytotoxic effect correlated to the surface exposure level of phosphatidylserine on the tumor cells. [PLoS One] Full Article | Press Release HOXB7 mRNA Is Overexpressed in Pancreatic Ductal Adenocarcinomas and Its Knockdown Induces Cell Cycle Arrest and Apoptosis In the present study, the effects arising from the knockdown of HOXB7 homeobox gene (HOXB7) in pancreatic ductal adenocarcinoma cell lines was investigated. [BMC Cancer] Abstract | Full Article Knockdown of RON Receptor Kinase Delays but Does Not Prevent Tumor Progression while Enhancing HGF/MET Signaling in Pancreatic Cancer Cell Lines The role of RON (receptor originated from nantes) in tumor progression was investigated in context with MET expression and activity. RON and MET expressions were not detected in an immortalized normal human pancreas cell line, but were co-expressed in five of seven pancreatic ductal adenocarcinoma cell lines. [Oncogenesis] Full Article |