DIABETES & PANCREATITIS Uncoupling Protein-2 Mediates the Protective Action of Berberine against Oxidative Stress in Rat Insulinoma INS-1E Cells and in Diabetic Mouse Islets Scientists investigated the effects of berberine, a botanical alkaloid purified from Coptidis rhizoma, on oxidative stress and insulin secretion through restoration of the uncoupling protein-2 expression in high glucose-treated INS-1E cells and rat islets or in db/db mouse islets. [Br J Pharmacol] Abstract Anti-TCR Therapy Combined with Fingolimod for Reversal of Diabetic Hyperglycemia by ß Cell Regeneration in the LEW.1AR1-iddm Rat Model of Type 1 Diabetes The therapeutic capacity of an antibody directed against the T cell receptor (anti-TCR) of the TCR/CD3 complex alone or in combination with fingolimod to reverse the diabetic metabolic state through suppression of autoimmunity and stimulation of ß cell regeneration was analyzed in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes. [J Mol Med] Abstract Progesterone Induces Apoptosis of Insulin-Secreting Cells: Insights into the Molecular Mechanism Investigators showed that progesterone can be toxic to pancreatic ß-cells through an oxidative stress-dependent mechanism inducing apoptosis. [J Endocrinol] Abstract | Full Article Macrophage Contact Dependent and Independent TLR4 Mechanisms Induce ß-Cell Dysfunction and Apoptosis in a Mouse Model of Type 2 Diabetes Researchers evaluated the expression and the function of the toll-like receptor 4 (TLR4) on pancreatic ß-cells in primary mouse islets and on the murine ß-cell line MIN6 in the presence or absence of macrophages. [PLoS One] Full Article PANCREATIC CANCER Pancreatic Satellite Cells Derived Galectin-1 Increase the Progression and Less Survival of Pancreatic Ductal Adenocarcinoma The roles of pancreatic satellite cells isolated from pancreatic ductal adenocarcinoma and normal pancreas on the proliferative activity, MMP2 and MMP9 expression, and the invasion of CFPAC-1 in the co-cultured system, as well as on the tumor establishment and development in mouse xenografts by mixed implanting with CFPAC-1 subcutaneously were evaluated. [PLoS One] Full Article Resveratrol Plays Dual Roles in Pancreatic Cancer Cells Resveratrol treatment inhibited tumor growth, induced apoptosis, and up-regulated Bax expression in a pancreatic cell line (capan-2 cells). [J Cancer Res Clin Oncol] Abstract Pristimerin, a Quinonemethide Triterpenoid, Induces Apoptosis in Pancreatic Cancer Cells through the Inhibition of Pro-Survival Akt/NF-?B/mTOR Signaling Proteins and Anti-Apoptotic Bcl-2 Scientists evaluated the anticancer activity and the mechanism of action of pristimerin, a quinonemethide triterpenoid, against MiaPaCa-2 and Panc-1 pancreatic ductal adenocarcinoma cell lines. [Int J Oncol] Abstract Effect of NK4 Transduction in Bone Marrow-Derived Mesenchymal Stem Cells on Biological Characteristics of Pancreatic Cancer Cells Mesenchymal stem cells expressing NK4 strongly inhibited proliferation and migration of the pancreatic cancer cell line SW1990 after co-culture. [Int J Mol Sci] Abstract | Download Full Article |