Pancreatic Cell News Volume 5.11 | Mar 25 2014

Calcium-Signaling Components in Rat Insulinoma ß-Cells (INS-1) and Pancreatic Islets Are Differentially Influenced by Melatonin
In a transfected INS-1 cell line overexpressing the human MT2 receptor, melatonin treatment induced even stronger depressive effects on calcium/calmodulin-dependent kinase 2d and IV transcripts during 3-isobutyl-1-methylxanthine treatment than in normal INS-1 cells, indicating a crucial influence of melatonin receptor density on transcript level regulation. [J Pineal Res] Abstract

SH2B1 in ß Cells Promotes Insulin Expression and Glucose Metabolism in Mice
Scientists identified SH2B1 as a new regulator of insulin expression. In rat INS-1 832/13 ß cells, SH2B1 knockdown decreased, whereas SH2B1 overexpression increased, both insulin expression and glucose-stimulated insulin secretion. [Mol Endocrinol] Abstract

Group VIA Phospholipase A₂ Mitigates Palmitate-Induced Beta Cell Mitochondrial Injury and Apoptosis
Group VIA phospholipase A₂ (iPLA₂ß) affects ß-cell sensitivity to apoptosis, and researchers examined iPLA2ß effects on events that occur in ß-cells incubated with palmitate. [J Biol Chem] Abstract | Full Article

Elevation of NR4A3 Expression and Its Possible Role in Modulating Insulin Expression in the Pancreatic Beta Cell
Dynamic changes in NR4A3 were examined in a pancreatic beta-cell line, MIN6, treated with thapsigargin, palmitate, tunicamycin, and dithiothreitol, chemicals that produce cell stress and even apoptosis. [PLoS One] Full Article

PANCREATIC CANCER

CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Overexpression of CLPTM1L enhanced growth of pancreatic cancer cells in vitro and in vivo, suggesting a role in tumor growth. [Cancer Res] Abstract

Activation of Glucagon-Like Peptide-1 Receptor Inhibits Tumorigenicity and Metastasis of Human Pancreatic Cancer Cells via PI3K/Akt Pathway
Glucagon-like peptide-1 receptor activation with liraglutide inhibited tumorigenicity and metastasis of human pancreatic cancer cells in vitro and in vivo. [Diabetes Obes Metab] Abstract

Development of High-Content Gemcitabine PEGylated Liposomes and Their Cytotoxicity on Drug-Resistant Pancreatic Tumor Cells
Researchers developed high-content gemcitabine PEGylated liposomes to reverse gemcitabine resistance in pancreatic tumor cells. The mechanism of drug loading into liposomes was also investigated. [Pharm Res] Abstract

The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer
Notch pathway components were found to be upregulated in pancreatic cancer stem cells (CSCs). Inhibition of the Notch pathway using either a gamma secretase inhibitor or Hes1 shRNA in pancreatic cancer cells reduced the percentage of CSCs and tumorsphere formation. [PLoS One] Full Article

A Triple Combination of Atorvastatin, Celecoxib and Tipifarnib Strongly Inhibits Pancreatic Cancer Cells and Xenograft Pancreatic Tumors
Researchers found that treatment of human pancreatic tumor cells with a combination of atorvastatin, celecoxib and tipifarnib had a stronger inhibitory effect on growth and a stronger stimulatory effect on apoptosis than each drug alone or for any combination of two drugs. [Int J Oncol] Abstract

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Ohio State Partners with MedVax Technologies, Inc. to Bring a Cancer Peptide Vaccine to Patients
The Ohio State University, through the Ohio State Innovation Foundation, has signed an exclusive world-wide licensing agreement with MedVax Technologies, Inc., for the licensing of groundbreaking cancer peptide vaccine technologies. [The Ohio State University] Press Release

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Postdoctoral Fellow – Translational Pancreatic Cancer Research (Medical College of Wisconsin)

Senior Research Coordinator (Joslin Diabetes Center)

Diabetes Researchers – Pathway to Stop Diabetes (American Diabetes Association)

Postdoc Researcher – Diabetes (Indiana University School of Medicine)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Studentship – Molecular Drug Resistance (Institute of Cancer Research)

Postdoctoral Position – Diabetes (Université de Sherbrooke)

Postdoctoral Position – Diabetes Research (Tel Aviv University)

Postdoctoral Position – Diabetes (Washington University School of Medicine)

Postdoctoral Research Fellow/Associate – Diabetes, Metabolism and Molecular Endocrinology (University of Illinois)

Postdoctoral Positions – Cancer and Diabetes (University of Pennsylvania)

Postdoctoral Fellow – Stem Cell Biology (McEwen Centre for Regenerative Medicine/University Health Network)

Postdoctoral Associate Specialist – Human Pancreatic Stem Cell Research (The Nestlé Institute of Health Sciences)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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