Pancreatic Cell News Volume 5.40 | Oct 21 2014

CRFR1 Activation Protects against Cytokine-Induced Beta Cell Death
In rat and mouse insulin secreting cell lines corticotropin releasing factor receptor 1 (CRFR1) agonists upregulated insulin receptor substrate 2 expression, increased AKT activation, counteracted cytokine-mediated decrease in BAD phosphorylation, and inhibited apoptosis. [J Mol Endocrinol] Abstract

Comparison of Therapeutic Characteristics of Islet Cell Transplantation Simultaneous with Pancreatic Mesenchymal Stem Cell Transplantation in Rats with Type 1 Diabetes Mellitus
Researchers investigated the effect of pancreatic mesenchymal stem cell transplantation simultaneous with islet cell transplantation on islet liveliness and thus on the treatment of diabetes in type 1 diabetic rats. [Stem Cell Rev] Abstract

Ameliorated Pancreatic β Cell Dysfunction in Type 2 Diabetic Patients Treated with a Sodium-Glucose Cotransporter 2 Inhibitor Ipragliflozin
Scientists investigated β cell function after a four-week treatment with a sodium-glucose cotransporter 2 inhibitor ipragliflozin in Japanese patients with type 2 diabetes mellitus. [Endocr J] Abstract | Full Article

The Tetraspanin CD9 Is Involved in Pancreatic Damage during Caerulein-Induced Acute Pancreatitis in Mice
The tetraspanin CD9 was reported to mediate inflammatory signaling through regulating molecular organization at the cell surface. Scientists investigated the role of CD9 during caerulein-induced experimental acute pancreatitis in mice. [J Dig Dis] Abstract

PANCREATIC CANCER

Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
Scientists characterized the therapeutic efficacy of a systemically administered formulation of 3-bromopyruvate, microencapsulated in a complex with β-cyclodextrin, using an orthotopic xenograft mouse model of pancreatic ductal adenocarcinoma. [Clin Cancer Res] Abstract

Human Equilibrative Nucleoside Transporter-1 Knockdown Tunes Cellular Mechanics through Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells
Researchers report cell mechanical changes in response to alteration of expression of the human equilibrative nucleoside transporter-1 (hENT1), a most abundant and widely distributed plasma membrane nucleoside transporter in human cells and/or tissues. Cellular phenotypic changes such as cell morphology, migration, and expression level of epithelial-mesenchymal transition (EMT) markers were observed after hENT1 knockdown. [PLoS One] Full Article

Anticancer Effects on Human Pancreatic Cancer Cells of Triterpenoids, Polysaccharides and 1,3-β-D-Glucan Derived from the Fruiting Body of Antrodia camphorata
Researchers analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in A. camphorata extracts (ACE). ACE exhibited a selective cytotoxic effect on BxPC-3 human pancreatic cancer cells. [Food Funct] Abstract

CRKL Protein Overexpression Enhances Cell Proliferation and Invasion in Pancreatic Cancer
Scientists found that CRKL expression in pancreatic cancer specimens was higher than that in normal pancreatic tissues. Colony formation assay and Matrigel invasion assay showed that the overexpression of CRKL in Bxpc3 and Capan2 cell lines with low endogenous expression increased cell proliferation and invasion. [Tumor Biol] Abstract

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MabVax Therapeutics Nominates the Fully Human Antibody HuMab 5B1 as the Company’s Lead Clinical Development Candidate
MabVax Therapeutics Holdings, Inc. announced that it has formally nominated its HuMab 5B1 antibody as a clinical candidate for the diagnosis and treatment of pancreatic and colon cancer. [MabVax Therapeutics Holdings, Inc.] Press Release

First Patient Successfully Implanted in Safety/Efficacy Study of Beta-O2’s ßAir Bio-Artificial Pancreas for Type 1 Diabetes
Beta-O2 announced that the first patient participating in the company’s first broad study of the ßAir Bio-Artificial Pancreas has been successfully implanted. [Beta-O2 (PR Newswire Association LLC)] Press Release

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Postdoctoral Candidate – Pancreatic Cancer Research (UT Southwestern)

Research Assistant – Diabetes/Metabolic Health (The Nestlé Institute of Health Sciences)

Postdoctoral Fellow – Biochemistry (University of Utah)

Postdoctoral Fellow – Cancer Genome Analysis (Ontario Institute for Cancer Research)

Full or Associate Professor – Endocrinology, Diabetes and Metabolism (University of Pennsylvania)

Research Associate – Bioengineering (Fred Hutchinson Cancer Research Center)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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