DIABETES & PANCREATITIS Pancreatic Beta Cells Are Highly Susceptible to Oxidative and ER Stress during the Development of Diabetes In addition to studying islets isolated from non-obese diabetic mice, investigators analyzed homogenous cell populations of murine alpha and beta cell lines to understand the role and differential survival of these two predominant islet cell populations. [J Proteome Res] Abstract Possible Contribution of Taurine to Distorted Glucagon Secretion in Intra-Islet Insulin Deficiency: A Metabolome Analysis Using a Novel α-Cell Model of Insulin-Deficient Diabetes To investigate the metabolic traits that underlie the distortion of glucagon secretion under insulin deficient conditions, scientists generated an αTC1-6 cell line with stable knockdown of the insulin receptor, i.e., an in vitro α-cell model for insulin-deficient diabetes, which exhibits an abnormal glucagon response to glucose. [PLoS One] Full Article Nerve Growth Factor Neutralization Suppresses β-Cell Proliferation through Activin A and Betacellulin Researchers investigated the effects of nerve growth factor neutralization on synthesis and secretion of activin A and betacellulin from primary β cells and the importance of these relations for β-cell proliferation. [Pancreas] Abstract Lycopene Protects Pancreatic Acinar Cells against Severe Acute Pancreatitis by Abating the Oxidative Stress through JNK Pathway The authors investigated the anti-oxidative and anti-inflammatory effects of lycopene on severe acute pancreatitis (SAP) in both in vivo and in vitro models. Utilizing a rat model, they found that lycopene administration protected against SAP, as indicated by the decreased levels of serum amylase and C-reaction protein. [Free Radic Res] Abstract PANCREATIC CANCER STAT3 Induces Anoikis Resistance, Promotes Cell Invasion and Metastatic Potential in Pancreatic Cancer Cells Researchers demonstrate that significant proportion of pancreatic cancer cells resisted anoikis when grown under anchorage-independent conditions and the cells that resisted anoikis showed higher migratory and invasive characteristics than the cells that were cultured under anchorage dependent condition. [Carcinogenesis] Abstract Anterior Gradient 2 Downregulation in a Subset of Pancreatic Ductal Adenocarcinoma Is a Prognostic Factor Indicative of Epithelial-Mesenchymal Transition To confer a more aggressive phenotype and induce epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma (PDAC) cells, investigators co-cultured PDAC cell lines with primary-cultured pancreatic stellate cells and found that anterior gradient 2 was downregulated in co-cultured PDAC cells compared with PDAC monocultures. [Lab Invest] Abstract miR-371-5p Facilitates Pancreatic Cancer Cell Proliferation and Decreases Patient Survival Scientists investigated the roles of miR-371-5p in pancreatic cancer and its association with the survival of patients with pancreatic cancer. The in vitro and in vivo assays showed that overexpression of miR-371-5p resulted in cell proliferation and increased tumor growth, which was associated with inhibitor of growth 1 downregulation. [PLoS One] Full Article Up-Regulation of UHRF1 by Oncogenic Ras Promoted the Growth, Migration, and Metastasis of Pancreatic Cancer Cells Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) was shown to promote the growth, migration, and metastasis of pancreatic cancer cells in vitro and in vivo. It was found that the expression of UHRF1 was significantly up-regulated in pancreatic cancer samples compared to their adjacent normal tissues. [Mol Cell Biochem] Abstract PKM2 Gene Regulates the Behavior of Pancreatic Cancer Cells via Mitogen-Activated Protein Kinase Pathways The authors investigated the effect of the PKM2 gene on the proliferation, invasion, migration and apoptosis of Panc-1 and Sw1990 pancreatic cancer cells via its interaction with the mitogen-activated protein kinases signaling pathways. [Mol Med Rep] Abstract |