DIABETES & PANCREATITIS Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells Scientists show that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally mature β cells in mice. [Cell Rep] Full Article | Graphical Abstract RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells Researchers demonstrate the presence of RFX6 in adult human pancreatic endocrine cells. Using the recently developed human β cell line EndoC-βH2, they show that RFX6 regulates insulin gene transcription, insulin content, and secretion. [Cell Rep] Full Article | Graphical Abstract PED/PEA-15 Inhibits Hydrogen Peroxide-Induced Apoptosis in Ins-1E Pancreatic Beta-Cells via PLD-1 Researchers investigated PED/PEA-15 role in hydrogen peroxide-induced apoptosis in Ins-1E beta-cells. In pancreatic islets isolated from TgPED/PEA-15 mice hydrogen peroxide-induced DNA fragmentation was lower compared to wild type islets. [PLoS One] Full Article Autologous Islet Transplantation with Remote Islet Isolation after Pancreas Resection for Chronic Pancreatitis Scientists investigated outcomes from a single institutional case series of near-total or total pancreatectomy and autologous islet transplantation using remote islet isolation. [JAMA Surg] Abstract PANCREATIC CANCER MicroRNA-206 Functions as a Pleiotropic Modulator of Cell Proliferation, Invasion and Lymphangiogenesis in Pancreatic Adenocarcinoma by Targeting ANXA2 and KRAS Genes Researchers found microRNA (miR)-206 to be abrogated in human pancreatic ductal adenocarcinoma (PDAC) specimens and cell lines. They show that miR-206 directly targets the oncogenes KRAS and annexin a2 (ANXA2), thereby acting as tumor suppressor in PDAC cells by blocking cell cycle progression, cell proliferation, migration and invasion. [Oncogene] Full Article Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2 Ref-1 has emerged as a promising therapeutic target in cancer, particularly in pancreatic ductal carcinoma. Scientists demonstrate that repression of Ref-1 potently activates nuclear factor-erythroid-related factor 2 (NRF2) and its downstream targets in a dose-dependent fashion, and that the redox, rather than the DNA repair function of Ref-1 is critical for this effect. [J Biol Chem] Abstract | Full Article Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells Scientists show that treatment of pancreatic ductal adenocarcinoma cells with the isoquinoline alkaloid berberine inhibited DNA synthesis and proliferation of these cells and delay the progression of their cell cycle in G1. [PLoS One] Full Article Neurotrophic Factor Artemin Promotes Invasiveness and Neurotrophic Function of Pancreatic Adenocarcinoma In Vivo and In Vitro Overexpression of artemin in pancreatic cancer cell lines improved colony formation, cell migration, matrigel invasion, and neurotrophic activity in vitro. [Pancreas] Full Article |