DIABETES & PANCREATITIS Overcoming Insulin Insufficiency by Forced Follistatin Expression in β-Cells of db/db Mice Scientists describe a therapeutic strategy to preserve β-cell function by overexpression of follistatin (FST) using an AAV vector in diabetic mouse model. Overexpression of FST in the pancreas of db/db mouse increased β-cell islet mass, decreased fasting glucose level, alleviated diabetic symptoms, and essentially doubled lifespan of the treated mice. [Mol Ther] Abstract Expression of the Kynurenine Pathway Enzymes in the Pancreatic Islet Cells. Activation by Cytokines and Glucolipotoxicity Using normal rat islets and the INS-1 β-cell line, scientists demonstrated for the first time that only some TKP genes are constitutively expressed, both in β-cells as well as non β-cells. [Biochim Biophys Acta] Abstract Impact of Sox9 Dosage and Hes1-Mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice Using Sox9-IRES-CreERT2 knock-in mice as a model, researchers analyzed how plasticity is controlled in adult ducts. Adult duct cells in these mice express less Sox9 than do wild-type mice but Hes1 equally. Acinar cell differentiation was accelerated by Hes1 inactivation, but suppressed by NICD induction in adult Sox9-expressing cells. [Sci Rep] Full Article Non-Receptor Tyrosine Kinase Inhibitors Enhances β-Cell Survival by Suppressing the PKCδ Signal Transduction Pathway in Streptozotocin-Induced β-Cell Apoptosis Scientists determined the effects of GNF-2, GNF-5 on pancreatic β-cell death caused by streptozotocin (STZ). STZ treatment causes apoptosis of INS-1 cells by activation of intracellular reactive oxygen species, c-jun N-terminal kinase, caspase 3, and caspase 3-dependent activation of protein kinase C delta (PKCδ). [Cell Signal] Abstract PANCREATIC CANCER S100A4 Promotes Pancreatic Cancer Progression through a Dual Signaling Pathway Mediated by Src and Focal Adhesion Kinase The effects of loss or gain of S100A4 were examined in pancreatic cancer cell lines. S100A4 downregulation remarkably reduces cell migration and invasion, inhibits proliferation, and induces apoptosis in pancreatic tumor cells. [Sci Rep] Full Article Cofilin-Phosphatase Slingshot-1L (SSH1L) Is Over-Expressed in Pancreatic Cancer (PC) and Contributes to Tumor Cell Migration Slingshot-1L (SSH1L) expression was shown to be up-regulated in PC cell lines with high metastatic potential. Loss of SSH1L expression was associated with an increase in the phosphorylation of cofilin-1 at serine-3 and further inhibit cell migration (but not proliferation) in KLM1, PANC-1 and MIAPaCa-2. [Cancer Lett] Abstract Restoration of TRAIL-Induced Apoptosis in Resistant Human Pancreatic Cancer Cells by a Novel FAK Inhibitor, PH11 Researchers showed that treatment with PH11, a novel focal adhesion kinase inhibitor in association with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) rapidly induces apoptosis in TRAIL-resistant PANC-1 cells, but not in normal human fibroblast cells. [Cancer Lett] Abstract Gradual Telomere Shortening and Increasing Chromosomal Instability among PanIN Grades and Normal Ductal Epithelia with and without Cancer in the Pancreas To study telomere shortening in precancerous pancreatic lesions, scientists measured telomere lengths using quantitative fluorescence in situ hybridization in the normal pancreatic duct epithelium, pancreatic intraepithelial neoplasias (PanINs), and cancers. [PLoS One] Full Article ZGDHu-1 Suppresses the Proliferation of PANC-1 Pancreatic Cancer Cells via Apoptosis and G2/M Cell Cycle Arrest Using an MTT assay, scientists found that ZGDHu-1 significantly suppressed the proliferation of PANC-1 cells in a time- and dose-dependent manner. [Oncol Rep] Abstract |