DIABETES & PANCREATITIS Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass Scientists found that glucagon receptor inhibition reduced hepatic amino acid catabolism, increased serum amino acids, and induced α-cell proliferation in an mTOR-dependent manner. In addition, mTOR inhibition blocked amino-acid-dependent α-cell replication ex vivo and enabled conversion of α-cells into β-like cells in vivo. [Cell Rep] Full Article | Graphical Abstract Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human Beta Cells The authors explored the prolactin (PRL)-prolactin receptor (hPRLR)-JAK2-STAT5-cyclin-cdk signaling cascade in human beta cells. Adult human beta cells express little or no PRLR. Restoration of the hPRLR in human beta cells rescued JAK2-STAT5 signaling in response to PRL. [Diabetes] Abstract The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from ER-Stress-Mediated Apoptosis Investigators analyzed the role of NR4A1 in ER-stress-mediated β-cell apoptosis and to characterize the related mechanisms. They confirmed that upon treatment with the ER stress inducers thapsigargin or palmitic acid, the mRNA and protein levels of NR4A1 rapidly increased in both MIN6 cells and mouse islets. [J Biol Chem] Abstract | Full Article REST Represses a Subset of the Pancreatic Endocrine Differentiation Program Scientists investigated the role of REST in the differentiation of pancreatic endocrine cells, which are molecularly close to neurons. They showed that Rest is widely expressed in pancreas progenitors and that it is down-regulated in differentiated endocrine cells. [Dev Biol] Abstract Phloroglucinol Protects INS-1 Pancreatic β-Cells against Glucotoxicity-Induced Apoptosis Researchers investigated whether phloroglucinol protected pancreatic β-cells against glucotoxicity-induced apoptosis using a rat insulinoma cell line (INS-1). High glucose treatment induced INS-1 cell death; however, the level of glucose-induced apoptosis was significantly reduced in cells treated with 100 μM phloroglucinol. [Phytother Res] Abstract PANCREATIC CANCER The Acinar Differentiation Determinant PTF1A Inhibits Initiation of Pancreatic Ductal Adenocarcinoma Scientists demonstrated that PTF1A expression is lost in both mouse and human pancreatic intraepithelial neoplasias, and that this downregulation is functionally imperative in mice for acinar reprogramming by oncogenic KRAS. [eLife] Abstract | Full Article Interaction between MicroRNA-181a and TNFAIP1 Regulates Pancreatic Cancer Proliferation and Migration MicroRNA (miR)-181a inhibitor lentivirus was used to down-regulate miR-181a in Capan-1 and AsPC-1 cells. The effects of miR-181a down-regulation on pancreatic cancer were evaluated by in vitro proliferation assay and migration assay. [Tumor Biol] Abstract miR-216a May Inhibit Pancreatic Tumor Growth by Targeting JAK2 The authors investigated miR-216a expression in pancreatic cancer and determined its effects on proliferation. miR-216a was found downregulated in pancreatic cancer tissues as compared to benign pancreatic lesions. [FEBS Lett] Abstract |