Pancreatic Cell News Volume 6.34 | Sep 1 2015

Identification of the Interaction of VP1 with GM130 which May Implicate in the Pathogenesis of CVB3-Induced Acute Pancreatitis
Researchers identified the host factor Golgi matrix protein 130 (GM130) as a novel target of coxsackievirus B3 (CVB3) during CVB3-induced acute pancreatitis. [Sci Rep] Full Article

Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells
Investigators explored the relationship between mouse maternal expressed gene 3 (Meg3) and the function of mouse beta cells in vitro and in vivo. [J Cell Physiol] Abstract

Primary Outgrowth Cultures Are a Reliable Source of Human Pancreatic Stellate Cells
Investigators examined whether outgrowth cultures from human surgical specimens exhibited reproducible phenotypic and functional characteristics of pancreatic stellate cells. [Lab Invest] Abstract

PANCREATIC CANCER

Myoferlin Plays a Key Role in VEGFA Secretion and Impacts Tumor-Associated Angiogenesis in Human Pancreas Cancer
Researchers showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. [Int J Cancer] Abstract

Prostaglandin E₂ Activates the mTORC1 Pathway through an EP4/cAMP/PKA and EP1/Ca²⁺-Mediated Mechanism in the Human Pancreatic Carcinoma Cell Line PANC-1
In PANC-1 human pancreatic cancer cells, scientists showed that PGE₂ stimulated mammalian target of rapamycin complex 1 (mTORC1) activity independently of Akt, as evaluated by downstream signaling events. [Am J Physiol Cell Physiol] Abstract

Characterization of Novel Carcinoma Cell Lines for the Analysis of Therapeutical Strategies Fighting Pancreatic Cancer
The murine pancreatic adenocarcinoma cell lines 6606PDA and 7265PDA were compared to the 6606l cell line isolated from a liver metastasis from mice suffering from pancreatic cancer. In tissue culture 6606PDA and 6606l proliferated faster than 7265PDA. [Cell Biosci] Full Article

PEBP4 Promoted the Growth and Migration of Cancer Cells in Pancreatic Ductal Adenocarcinoma
Investigators found that the messenger RNA and protein level of phosphatidylethanolamine-binding protein 4 (PEBP4) was elevated in pancreatic ductal adenocarcinoma (PDAC) samples. Forced expression of PEBP4 in PDAC cell lines promoted cell growth and migration, while downregulation of PEBP4 in PDAC cells by RNA interference (RNAi) inhibited the growth, migration, and metastasis of the cancer cells. [Tumour Biol] Abstract

Effects of Cerulein on Keratin 8 Phosphorylation and Perinuclear Reorganization in Pancreatic Cancer Cells: Involvement of Downregulation of Protein Phosphatase 2A and Alpha4
Researchers found that cerulein dose-dependently induced keratin 8 phosphorylation and perinuclear reorganization in PANC-1 cells, thus leading to migration and invasion. [Environ Toxicol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

From our sponsor:
Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.

Novo Nordisk to Initiate Phase IIIa Development of Oral Semaglutide, a Once-Daily Oral GLP-1 Analogue
Novo Nordisk announced the decision to initiate a Phase IIIa programme with oral semaglutide; a once-daily oral formulation of the long-acting GLP-1 analogue semaglutide. [Novo Nordisk A/S] Press Release

U.S. FDA Approves Synjardy^® (Empagliflozin/Metformin Hydrochloride) Tablets for Adults with Type 2 Diabetes
The U.S. Food and Drug Administration (FDA) has approved Synjardy^® tablets, from Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company, for the treatment of adults with type 2 diabetes. [Eli Lilly and Company] Press Release

NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science
The National Institutes of Health (NIH) has awarded the University of Alabama at Birmingham (UAB) Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research. [University of Alabama at Birmingham] Press Release

Immatics and MD Anderson Announce Launch of Immatics US, Inc., to Develop Multiple T-Cell and TCR-Based Adoptive Cellular Therapies
Immatics Biotechnologies GmbH and The University of Texas MD Anderson Cancer Center announced the launch of Immatics US, Inc., a new company aiming at becoming a global leader in adoptive cellular therapies for the treatment of a range of tumor types. [The University of Texas MD Anderson Cancer Center] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the pancreatic cell community.

NEW Postdoctoral Position – Diabetes Research (Albert Einstein College of Medicine of Yeshiva University)

NEW Postdoctoral Research Fellow – Translational Research Program (Fred Hutchinson Cancer Research Center)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Research Scientist – Pancreatic Cancer (Columbia University)

Clinical Lecturer (University of Bristol)

Postdoctoral Position – Metabolic Diseases (ETH Zürich)

Postdoctoral Research Fellow – Development and Pathogenesis of Pancreatic Cancer (University College London)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.