DIABETES & PANCREATITIS Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation The authors showed that islets from diabetes-susceptible New Zealand Obese mice, in contrast to diabetes-resistant C57BL/6J-ob/ob mice, do not proliferate in response to an in vivo glucose challenge but lose their beta-cells. [PLoS Genet] Full Article Interaction of Dendritic Cells and T Lymphocytes for the Therapeutic Effect of Dangguiliuhuang Decoction to Autoimmune Diabetes Investigators studied potential anti-diabetic mechanisms of Dangguiliuhuang decoction (DGLHD) in a non-obese diabetic mouse model. DGLHD increased α1-antitrypsin, Bcl-2, and CyclinD1, and decreased Bax levels in pancreas, spleen, thymus, dendritic cells, and a NIT-1 cell line, all consistent with protecting and repairing islet β cell. [Sci Rep] Full Article miR-101a and miR-30b Contribute to Inflammatory Cytokine-Mediated β-Cell Dysfunction Researchers demonstrated that microRNA (miR)-101a and miR-30b are key players in cytokine-mediated β-cell dysfunction. They found that IL-1β induces an increase in miR-101a and miR-30b in MIN6 cells, and that the two miRNAs participate in β-cell dysfunction, including decreased insulin content, gene expression, and increased β-cell death. [Lab Invest] Abstract Increased Androgen Levels in Rats Impair Glucose-Stimulated Insulin Secretion through Disruption of Pancreatic Beta Cell Mitochondrial Function Scientists elucidated potential mechanisms involved in beta cell alterations in a rat model of polycystic ovary syndrome. Glucose-induced insulin secretion was measured in islets isolated from DHT-treated and control rats. [J Steroid Biochem Mol Biol] Abstract PANCREATIC CANCER Cancer Stem Cell Marker Phenotypes Are Reversible and Functionally Homogeneous in a Preclinical Model of Pancreatic Cancer Scientists isolated pancreatic cancer cells from multiple independent tumor lines and found that roughly 1 out of 87 cells exhibited tumorigenic capability. Three-dimensional spheroid cultures originating from KrasG12D/Trp53R172H/Pdx-1-Cr tumors did not enrich for cells with stem-like characteristics, and were not significantly more tumorigenic than cells cultured as monolayers. [Cancer Res] Abstract Secreted Protein Acidic and Rich in Cysteine Enhances the Chemosensitivity of Pancreatic Cancer Cells to Gemcitabine Researchers investigated the role of secreted protein acidic and rich in cysteine played in the sensitivity of pancreatic cancer to gemcitabine. They first treated MIAPaCa2 and MIAPaCa2/SPARC69 cells with different concentrations of gemcitabine for 24, 48, and 72 hours and selected the appropriated concentration for further study. [Tumor Biol] Abstract Effectiveness of Plasma Treatment on Pancreatic Cancer Cells Four pancreatic cancer cell lines were used and the antitumor effects of plasma-activated medium treatment were evaluated using a cell proliferation assay. To explore functional mechanisms, morphological change and caspase-3/7 activation in cells were also assessed. [Int J Oncol] Abstract MicroRNA-29a Promotes Pancreatic Cancer Growth by Inhibiting Tristetraprolin Researchers found that microRNA (miR)-29a was up regulated in pancreatic tumor tissues and cell lines and positively correlated with metastasis. Ectopic expression of miR-29a increased the expression of pro-inflammatory factors and epithelial-mesenchymal transition markers, through down regulating tristetraprolin. [Cell Physiol Biochem] Abstract | Full Article |