DIABETES & PANCREATITIS The Soybean Peptide Vglycin Preserves the Diabetic β-Cells through Improvement of Proliferation and Inhibition of Apoptosis Researchers present a polypeptide vglycin, which was isolated and purified from germinating pea seeds. Vglycin exhibited positive effects in our diabetic models by promoting the proliferation and suppressing the apoptosis and dedifferentiation of β-cells. [Sci Rep] Full Article Evaluation of Low Doses BPA-Induced Perturbation of Glycemia by Toxicogenomics Points to a Primary Role of Pancreatic Islets and to the Mechanism of Toxicity Scientists took a toxicogenomic approach to investigate the mechanisms of low-dose bisphenol A (BPA) toxicity in ex vivo cultures of primary murine pancreatic islets and hepatocytes. [Cell Death Dis] Full Article Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells Porosomes have been functionally reconstituted for the first time in live cells. Isolated Min6 porosomes reconstituted into live Min6 cells demonstrate augmented levels of porosome proteins and a consequent increase in the potency and efficacy of glucose-stimulated insulin release. [Endocrinology] Abstract Parathyroid Hormone-Related Protein Interacts with the Transforming Growth Factor-β/Bone Morphogenetic Protein-2/Gremlin Signaling Pathway to Regulate Proinflammatory and Profibrotic Mediators in Pancreatic Acinar and Stellate Cells Transforming growth factor β increased parathyroid hormone-related protein levels in acinar cells and pancreatic stellate cells through a Smad3-dependent pathway. [Pancreas] Abstract PANCREATIC CANCER Interplay between Gemcitabine and Erlotinib over Pancreatic Adenocarcinoma Cells The authors investigated the molecular interplay in vitro between gemcitabine and erlotinib regarding their effects over cytotoxicity, proliferation, apoptosis, and invasion. [Pancreas] Abstract Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer Researchers evaluated the efficacy of combination of triptolide and oxaliplatin against pancreatic cancer. Highly aggressive pancreatic cancer cells were treated with oxaliplatin, low-dose triptolide, or a combination of both for 24–48 hours. [J Gastrointest Surg] Abstract Cell Motility and Spreading Promoted by CEACAM6 through Cyclin D1/CDK4 in Human Pancreatic Carcinoma Scientists used siRNA and forced-expression in multiple cell lines to define the role of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in the regulation of proliferation of pancreatic carcinoma in vitro and in vivo. Knockdown of endogenous CEACAM6 decreased proliferation of BxPC-3 and SW1990 cells. [Oncol Rep] Abstract Ferulic Acid Decreases Cell Viability and Colony Formation while Inhibiting Migration of MIA PaCa-2 Human Pancreatic Cancer Cells In Vitro Scientists examined the effects of ferulic acid, a phenolic compound, on gene expression, viability, colony formation and migration/invasion in the cultured MIA PaCa-2 human pancreatic cancer cell. [Gene] Abstract |