DIABETES & PANCREATITIS Nucleotide-Binding Oligomerization Domain 1 Acts in Concert with the Cholecystokinin Receptor Agonist, Cerulein, to Induce IL-33-Dependent Chronic Pancreatitis Scientists explored the long-term outcome of nucleotide-binding oligomerization domain 1 (NOD1) responsiveness in a new model of chronic pancreatitis induced by repeated administration of low doses of cerulein in combination with NOD1 ligand. [Mucosal Immunol] Abstract Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-cells Researchers showed that isoxazole induces genes that support neuroendocrine and β-cell phenotypes and suppresses genes important for proliferation. Isoxazole alters β-cell metabolites and protects glucose-responsive signaling pathways under lipotoxic conditions. [ACS Chem Biol] Abstract Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence Investigators aimed to determine whether normal variations in enzyme-activities of collagenases applied for rat-islet isolation impact longevity of encapsulated islet grafts. They studied the functional and immunological properties of rat islets isolated with different enzyme preparations to determine whether this impacts these parameters. [PLoS One] Full Article PANCREATIC CANCER Functional Malignant Cell Heterogeneity in Pancreatic Neuroendocrine Tumors Revealed by Targeting of PDGF-DD Scientists identified the expression of platelet-derived growth factor receptor beta (PDGFRβ) as a previously unrecognized feature of a minor malignant cell population in pancreatic neuroendocrine tumors. [Proc Natl Acad Sci USA] Abstract Delivery of Improved Oncolytic Adenoviruses by Mesenchymal Stromal Cells for Elimination of Tumorigenic Pancreatic Cancer Cells Scientists evaluated improved oncolytic adenoviruses, in which the adenoviral gene E1B19K was deleted or a TRAIL transgene was inserted. The infection competence, tumor migration, and oncolysis were measured in cancer stem cell models of primary and established tumor cells and in tumor xenografts. [Oncotarget] Full Article GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression The authors aimed to investigate the mechanistic, functional and therapeutic role of GSK-3β in the regulation and activation of the pro-inflammatory oncogenic transcription factor NFATc2 in pancreatic cancer. [Mol Cancer Ther] Abstract Modeling Therapy Response and Spatial Tissue Distribution of Erlotinib in Pancreatic Cancer Scientists aimed to investigate the emerging technology of matrix assisted laser desorption/ionization imaging mass spectrometry as a powerful tool to study drug delivery and spatial tissue distribution in pancreatic ductal adenocarcinoma. [Mol Cancer Ther] Abstract miR-101-3p Reverses Gemcitabine Resistance by Inhibition of Ribonucleotide Reductase M1 in Pancreatic Cancer The expression of ribonucleotide reductase M1 correlated to gemcitabine resistance in vitro and was higher in malignant patient pancreas tissue compared to non-malignant pancreas tissue. By microRNA expression profiling, researchers identified microRNA-101-3p as top-downregulated candidate. [Cancer Lett] Abstract Profiling of cMET and HER Family Receptor Expression in Pancreatic Ductal Adenocarcinomas and Corresponding Lymph Node Metastasis to Assess Relevant Pathways for Targeted Therapies: Looking at the Soil before Planting the Seed The authors investigated 56 pancreatic ductal adenocarcinomas and corresponding lymph node metastases for HER1 to HER4 and cMET expression by immunohistochemistry, as well as cMET gene copy numbers by chromogenic in situ hybridization. [Pancreas] Abstract |