DIABETES & PANCREATITIS Asprosin, a Fasting-Induced Glucogenic Protein Hormone Scientists have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and they name it Asprosin. [Cell] Abstract | Graphical Abstract | Press Release PANCREATIC CANCER Genotype Tunes Pancreatic Ductal Adenocarcinoma Tissue Tension to Induce Matricellular Fibrosis and Tumor Progression The authors found that human pancreatic ductal carcinoma with impaired epithelial transforming growth factor-β signaling have high epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with high epithelial tension and shorter patient survival. [Nat Med] Abstract | Press Release Macrophage-Secreted Granulin Supports Pancreatic Cancer Metastasis by Inducing Liver Fibrosis Investigators found that pancreatic ductal adenocarcinoma liver metastasis critically depends on the early recruitment of granulin-secreting inflammatory monocytes to the liver. [Nat Cell Biol] Abstract | Press Release Downregulated miR-506 Expression Facilitates Pancreatic Cancer Progression and Chemoresistance via SPHK1/Akt/NF-κB Signaling Scientists discovered a novel epigenetic mechanism of miR-506 regulation and investigated its functional significance in pancreatic cancer. [Oncogene] Full Article HIC1 Attenuates Invasion and Metastasis by Inhibiting the IL-6/STAT3 Signaling Pathway in Human Pancreatic Cancer Investigators aimed to clarify the clinical relevance of hypermethylated in cancer 1 (HIC1) and human pancreatic cancer and the mechanism of its effect on invasion and metastasis. HIC1 was downregulated in pancreatic cancer patient cancer tissue and pancreatic cancer cell lines. [Cancer Lett] Abstract Evaluation of Expansile Nanoparticle Tumor Localization and Efficacy in a Cancer Stem Cell-Derived Model of Pancreatic Peritoneal Carcinomatosis Scientists evaluated the tumor localization and efficacy pH-responsive expansile nanoparticles as a drug delivery system for pancreatic peritoneal carcinomatosis modeled in nude rats. [Nanomedicine (Lond)] Abstract Metabolomics Reveals Mycoplasma Contamination Interferes with the Metabolism of PANC-1 Cells Liquid chromatography mass spectrometry-based metabolomics was used to investigate the effect of mycoplasma contamination on the cellular metabolism of human pancreatic carcinoma cells (PANC-1). Multivariate analysis demonstrated that mycoplasma contamination induced significant metabolic changes in PANC-1 cells. [Anal Bioanal Chem] Abstract | Graphical Abstract Suppression of Pancreatic Ductal Adenocarcinoma Growth by Intratumoral Delivery of Attenuated Salmonella typhimurium Using a Dual Fluorescent Live Tracking System Investigators established CFPAC-1 cell lines expressing an mKate2 protein and thus emitting far-red fluorescence in the subsequent xenograft implant. VNP20009 strain was further engineered to carry a luciferase cDNA, which catalyzes the light-emitting reaction to allow the observation of Salmonella distribution and accumulation within tumor with live imaging. Using such VNP20009 strain and intratumoral delivery, the authors could reduce the growth of pancreatic cancer by inducing apoptosis and severe necrosis in a dosage dependent manner. [Cancer Biol Ther] Abstract |