DIABETES & PANCREATITIS Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice To investigate the in vivo antiviral activity of oroxylin A, researchers intraperitoneally inoculated Coxsackievirus B3 (CVB3) into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. [PLoS One] Full Article Caerulein-Induced Pancreatitis Augments the Expression and Phosphorylation of Collapsin Response Mediator Protein 4 Acute and chronic pancreatitis mice models were developed by periodic injection of caerulein. The expression levels of collapsin response mediator protein 4 and its phosphorylation were examined. [J Hepatobiliary Pancreat Sci] Abstract Extracellular ATP Protects Pancreatic Duct Epithelial Cells from Alcohol-Induced Damage through P2Y1 Receptor-cAMP Signal Pathway Using pancreatic duct epithelial cells, researchers found that a micromolar range of adenosine-5′-triphosphate (ATP) reverses all intracellular toxicity mechanisms triggered by exceptionally high doses of ethanol and, thus, improves cell viability dramatically. [Cell Biol Toxicol] Abstract PANCREATIC CANCER Administration of Gemcitabine after Pancreatic Tumor Resection in Mice Induces an Anti-Tumor Immune Response Mediated by Natural Killer Cells After electroporation of oncogenic plasmids, mice developed a single pancreatic tumor nodule with histopathological features of human pancreatic ductal adenocarcinoma (PDAC). Pancreatic tumors that expressed myrAkt2 (the active form of Akt2) infiltrated the surrounding pancreatic tissue and neurons and became widely metastatic, reflecting the aggressive clinical features of PDAC in patients. [Gastroenterology] Abstract IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC Scientists interrogated the Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) interaction network in pancreatic ductal adenocarcinoma cells. Using a combination of genome-wide approaches, they identified 164 direct mRNA targets of IGF2BP3. [Cell Rep] Full Article | Graphical Abstract | Press Release Arsenic Trioxide Plus PX-478 Achieves Effective Treatment in Pancreatic Ductal Adenocarcinoma Researchers showed that PX-478 (hypoxia-inducible factor-1 inhibitor) robustly strengthened the anti-growth and pro-apoptosis effect of arsenic trioxide (ATO) on Panc-1 and BxPC-3 pancreatic cancer cells in vitro. Meanwhile, in vivo mouse xenograft models also showed the synergistic effect of ATO plus PX-478 compared with any single agent. [Cancer Lett] Abstract Penfluridol Suppresses Pancreatic Tumor Growth by Autophagy-Mediated Apoptosis Investigators evaluated the effect of penfluridol against pancreatic cancer. Penfluridol treatment induced apoptosis and inhibited the growth of Panc-1, BxPC-3 and AsPC-1, pancreatic cancer cells with IC50 ranging between 6-7 μM after 24 hours of treatment. [Sci Rep] Full Article Downregulation of STAT3/NF-κB Potentiates Gemcitabine Activity in Pancreatic Cancer Cells Scientist hypothesized that Nexrutine® (Nx)-mediated inhibition of survival molecules like STAT3 and NF-κB in pancreatic cancer cells will improve the efficacy of the conventional chemotherapeutic agent, gemcitabine (GEM). Therefore, they explored the utility of Nx, one of its active constituents berberine and its derivatives, to enhance the effects of GEM. [Mol Carcinog] Abstract |