Pancreatic Cell News 7.21 May 31, 2016 | |
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TOP STORYCyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas Since telomerase activity is commonly activated in malignant cells, researchers evaluated the diagnostic performance of cyst fluid telomerase activity measurements for predicting histologic grade. [Clin Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe aim of this study was to identify the active compounds in extracts from two species of cinnamon responsible for pancreatic β-cell protection in vitro. [Acta Pharmacol Sin] Abstract The authors investigated the ability of human amniotic fluid stem cells to differentiate into insulin-producing cells. [J Diabetes Investig] Full Article PANCREATIC CANCERThe authors aimed to analyze the miRNome of pancreatic ductal adenocarcinoma and its preneoplastic lesion intraductal papillary mucinous neoplasm, to find new microRNA (miRNA)-based biomarkers for early detection of pancreatic neoplasia. [Ann Surg] Abstract Investigators postulated that the addition of stromal therapy may enhance the anti-tumor efficacy of chemotherapy. Gemcitabine and all-trans retinoic acid were combined in a clinically applicable regimen, to target cancer cells and pancreatic stellate cells respectively, in 3D organotypic culture models and genetically engineered mice representing the spectrum of pancreatic ductal adenocarcinoma. [J Pathol] Full Article | Press Release Scientists showed that the expression of Nampt, the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, was significantly increased in pancreatic ductal adenocarcinoma (PDAC) cells and PDAC tissues. Additionally, inhibition of Nampt impaired tumor growth in vitro and tumorigenesis in vivo, which was accompanied by a decreased cellular NAD level and glycolytic activity. [Cancer Lett] Abstract Investigators assessed the antitumor activity of APY606 against human pancreatic cancer Capan-1 and SW1990 cell lines and explored the effect of Ras-mitogen-activated protein kinase (MAPK) and apoptosis-related signaling pathway on the activity of APY606. [PLoS One] Full Article MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt Overexpressing miR-221 significantly increased cell vitality and promoted cell proliferation and G1-to-S phase transition of the cell cycle in Capan-2 cells, while inhibition of miR-221 decreased that. The protein level of PTEN in Capan-2 cells was downregulated by overexpressing miR-221, while upregulated by inhibiting miR-221. [Cell Physiol Biochem] Full Article Researchers examined the mast cell tryptase (MCT) levels in serum from pancreatic cancer patients and evaluated the correlation of the MCT level and tumor angiogenesis. In addition, the effect of MCT on endothelial cell proliferation and tube formation was investigated both in vitro and in nude mice bearing pancreatic tumor. [Int J Mol Sci] Full Article Evidence for the Role of MicroRNA 374b in Acquired Cisplatin Resistance in Pancreatic Cancer Cells To evaluate the potential contribution of miRNAs in acquired resistance to cisplatin in pancreatic cancer, investigators compared levels of more than 2000 human miRNAs in a cisplatin-resistant cell line (BxPC3-R) derived from parental (BxPC3) cells by step-wise exposure to increasing concentrations of the drug over more than 20 passages. [Cancer Gene Ther] Full Article | Press Release | |
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REVIEWSThe Potential of Endurance Exercise-Derived Exosomes to Treat Metabolic Diseases The reviewers propose that the systemic benefits of exercise are modulated by exosomes and/or microvesicles functioning in an autocrine, paracrine and/or endocrine manner. Furthermore, they posit that native or modified exosomes, and/or microvesicles enriched with exerkines will have therapeutic utility in the treatment of obesity and Type 2 Diabetes. [Nat Rev Endocrinol] Abstract The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression The possibility of intervention in the molecular mechanisms of miRNAs regulation could begin a new generation of PDAC therapies. This review summarizes the reports describing miRNAs involvement in cellular processes involving pancreatic carcinogenesis and their utility in diagnosis, survival and therapeutic potential in pancreatic cancer. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.
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SCIENCE NEWSDialing Up Chemotherapy for Pancreatic Cancer with Ultrasound Researchers have combined a laboratory ultrasound technique called “sonoporation” with the commercially-available chemotherapy compound Gemcitabine to increase the porosity of pancreatic cells with microbubbles and to help get the drug into cancer cells where it is needed. [Press release from the Acoustal Society of America (ASA) discussing research presented at ASA’s 171st Annual Meeting, Salt Lake City] Press Release Chemo, Radiation, Surgery Combo Boosts Survival for Pancreatic Cancer Patients with Veins Involved In roughly one-third of pancreatic cancer patients, tumors have grown around the pancreas to encompass critical blood vessels. Conventional wisdom has long held that surgery to remove the tumors is rarely an option, and life expectancies are usually measured in months. Doctors found that many of these patients actually are candidates for surgery. [Press release from Mayo Clinic discussing research presented at the Pancreas Club 50th Annual Meeting and the Society for Surgery of the Alimentary Tract (SSAT) 57th Annual Meeting, San Diego] Press Release | |
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INDUSTRY NEWSThe U.S. Food and Drug Administration (FDA) has approved Jentadueto® XR tablets for the treatment of type 2 diabetes in adults. [Boehringer Ingelheim and Eli Lilly and Company] Press Release AstraZeneca announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has issued a positive opinion, recommending the approval of saxa/dapa tablets for the treatment of adults with type-2 diabetes. [AstraZeneca] Press Release
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EVENTSNEW Gordon Research Conference – Tissue Niches & Resident Stem Cells in Adult Epithelia Visit our events page to see a complete list of events in the pancreatic cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher (Katholieke Universiteit Leuven) Research Associate – Pancreatic Cancer Pharmacology (University of Cambridge) Postdoctoral Fellow – Quantitative Hepato-Pancreatic MR Imaging (Inserm) Postdoctoral Fellow – Diabetes Mellitus and Metabolic Syndrome (Northwestern University) Associate Senior Lecturer – Medical Cell Biology or Physiology (Uppsala University) Postdoctoral Fellow(s) – Pancreatic Islet Biology (Vanderbilt University Medical Center) Postdoctoral Fellow – Pancreas Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Diabetic Peripheral Neuropathy (University of North Dakota) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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