Pancreatic Cell News 7.29 July 26, 2016 | |
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TOP STORYResearch Suggests That Diabetes Could Be Due to Failure of Beta Cell ‘Hubs’ The significant role of beta cell ‘hubs’ in the pancreas has been demonstrated for the first time, suggesting that diabetes may due to the failure of a privileged few cells, rather than the behaviour of all cells. [Cell Metab] Press Release | Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISResearchers used light-regulated synthesis or depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate, they found that this lipid positively regulated both depolarization- and glucose-triggered Ca2+ influx in a dose-dependent manner. [Cell Chem Biol] Abstract | Graphical Abstract Investigators studied the pathway by which sirtuin 6 (Sirt6) regulates glucose-stimulated insulin secretion utilizing mice lacking Sirt6 in their β cells. [Sci Rep] Full Article Lentinan Protects Pancreatic β Cells from STZ-Induced Damage Investigators evaluated the effect of lentinan, an active ingredient purified from the bodies of Lentinus edodes, on pancreatic β-cell apoptosis and dysfunction caused by streptozotocin (STZ) and the possible mechanisms implicated. [J Cell Mol Med] Full Article PANCREATIC CANCERScientists hypothesized that interactions between pancreatic adenocarcinoma cells and fibrotic tumor associated stroma cells within the microenvironment modulate microRNA (miRNA) expression and thus, tumor biology. [Oncotarget] Full Article The purpose of this study was to understand the mechanisms of exosomes-mediated cellular communication between human pancreatic cancer cells and macrophages using a Transwell co-culture system. [Sci Rep] Full Article Researchers comprehensively explored the antitumor efficacy, effect on metastatic dissemination, tumor stroma and survival advantage following gemcitabine (GEM), paclitaxel and albumin-bound paclitaxel (nab-PTX) as monotherapy or in combination with GEM in a locally advanced, and a highly metastatic orthotopic model of human pancreatic ductal adenocarcinoma (PDAC). [Br J Cancer] Abstract pH-Sensitive K+ Channel TREK-1 Is a Novel Target in Pancreatic Cancer Scientists investigated pH-regulated K+ currents in pancreatic ductal adenocarcinoma cells and determined possible effects on their pathological phenotype. [Biochim Biophys Acta] Abstract Scientists investigated the effects of nicotine on the proliferation, migration and invasion of the human pancreatic cancer cell lines Panc1 and BxPC3. [Biochim Biophys Acta] Abstract Researchers aimed to assess the effects of raf kinase inhibitor protein on pancreatic carcinoma cells in vitro and in tumor tissues in vivo. [J Cancer Res Clin Oncol] Abstract | |
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REVIEWSPancreatic Cancer Biology and Genetics from an Evolutionary Perspective The authors gather the wide-ranging aspects of pancreatic cancer research into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for study. [Nat Rev Cancer] Abstract Leveraging Mechanisms Governing Pancreatic Tumorigenesis to Reduce Pancreatic Cancer Mortality Pancreatic ductal adenocarcinoma (PDA) is a devastating malignancy with limited and modest clinical treatments. High-throughput technologies and accurate disease models now provide a comprehensive picture of the diverse molecular signaling pathways and cellular processes governing PDA tumorigenesis. [Trends Endocrinol Metab] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSAraim Pharmaceuticals announced that the US Food and Drug Administration has granted Orphan Drug Designation to its lead product candidate, Innate Repair Receptor activator ARA 290, for treatment to increase survival and improve functioning of pancreatic islets following transplantation. [PR Newswire Association LLC.] Press Release ViaCyte Awarded New CIRM Grant to Develop PEC-Direct for High-Risk Type 1 Diabetes ViaCyte, Inc. announced that the California Institute for Regenerative Medicine (CIRM) approved a grant of $3.9 million to support pre-clinical development of ViaCyte’s PEC-Direct cell therapy product candidate which is being developed for a subset of type 1 diabetes patients. [ViaCyte, Inc.] Press Release Shire plc announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion recommending the marketing authorization for the use of ONIVYDE®, for the treatment of metastatic adenocarcinoma of the pancreas, in combination with 5-fluorouracil and leucovorin, in adult patients who have progressed following gemcitabine based therapy. [Shire plc] Press Release Cancer Research UK Boosts Efforts to Overcome Deadliest Cancer as Rates Climb The charity increased spending on pancreatic cancer research – including improving diagnosis and treatment – to £18 million in the 2015/16 financial year, tripling the £6 million investment in 2013/14. [Cancer Research UK] Press Release | |
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POLICY NEWSTrump vs Clinton: Worlds Apart on Science Science is slowly coming into focus in the US presidential campaign. Although neither Republican Donald Trump nor Democrat Hillary Clinton has emphasized core research issues, the candidates — and their parties — are beginning to flesh out their positions on climate change, education, biomedical research and other topics that involve the scientific community. [Nature News] Editorial Public Is Wary of Using Technologies to Enhance Human Performance, Survey Finds A new poll finds that Americans have serious questions about the use of new technologies to enhance the lives of healthy people. Those with strong religious beliefs are especially troubled by the prospect of such enhancements, seeing them as meddling with nature. [ScienceInsider] Editorial Europe Overhauls Rules for ‘First-In-Human’ Trials in Wake of French Disaster The European Union is beefing up protections for volunteers in phase I clinical trials in the wake of a disastrous clinical study in Rennes, France, that resulted in the death of one volunteer and the hospitalization of five others. The European Medicines Agency in London announced in a “concept paper” that it wants to improve strategies to identify and reduce risks in “first-in-human” studies on healthy volunteers. [Science] Editorial Scientific Literature: Information Overload Recent bibliometrics show that the number of published scientific papers has climbed by 8–9% each year over the past several decades. In the biomedical field alone, more than 1 million papers pour into the PubMed database each year — about two papers per minute. For researchers who are already overwhelmed by bench and field work, grant-writing, publishing and other time-eaters, trying to navigate the growing deluge of data has become a second job. [Nature Careers] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) Asia 2016 Congress Visit our events page to see a complete list of events in the pancreatic cell community.
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JOB OPPORTUNITIESNEW PhD Positions – Chromatin and Metabolism (EU Marie Skłodowska-Curie Initial Training Network) Postdoctoral Researcher – Breast, Prostate, and Pancreatic Cancer (MD Anderson Cancer Center) Postdoctoral Research Assistant – Pancreatic Cancer (Queen Mary University of London) Research Program Manager – Pancreatic Cancer (University of Cambridge) Postdoctoral Fellow – Pancreatic Cancer Biology (New York University School of Medicine) Principal Investigator – Tenure Track Position (National Institutes of Health) Postdoctoral Fellowship – Various Projects (University of Pittsburgh) Postdoctoral Fellow – Pancreatic Cancer Metabolism (Thomas Jefferson University) Postdoctoral Fellows – Various Positions (Oregon Health & Science University) Postdoctoral Fellow – Quantitative Hepato-Pancreatic MR Imaging (Inserm) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Pancreatic Cell News Volume 7.29 | Jul 26 2016