Pancreatic Cell News 7.31 August 9, 2016 | |
| |
TOP STORYResearchers showed that pancreatic ductal adenocarcinoma cells can induce DNA methylation in cancer associated fibroblasts. [Cancer Res] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISIntrauterine growth restriction (IUGR) fetuses are characterized by lower glucose stimulated insulin secretion, smaller pancreatic islets with less β-cells, and impaired pancreatic vascularity. To test whether supplemental amino acids infused into the IUGR fetus could improve these complications of IUGR researchers used acute and chronic direct fetal amino acid infusions into a sheep model of placental insufficiency and IUGR near the end of gestation. [Endocrinology] Abstract | Full Article PANCREATIC CANCERHigh-throughput drug screens using patient-derived cell lines found rare examples of sensitivity to monotherapy, with most models requiring combination therapy. [Cell Rep] Full Article | Graphical Abstract | Press Release TGF-β1 Promotes Acinar to Ductal Metaplasia of Human Pancreatic Acinar Cells Scientists developed a flow cytometry-based, high resolution lineage tracing method and 3D culture system to analyse acinar-to-ductal metaplasia (ADM) in human cells. In this system, well-known mouse ADM inducers did not promote ADM in human cells. In contrast, TGF-β1 efficiently converted human acinar cells to duct-like cells in a SMAD-dependent manner. [Sci Rep] Full Article Scientists showed that PDHK1 activity is unique and non-redundant in the family of PHDK enzymes and a PDHK1 specific inhibitor would therefore have anti-cancer activity with reduced chance of side effects from inhibition of other PDHKs. [Sci Rep] Full Article Rab11a Sustains GSK3β/Wnt/β-Catenin Signaling to Enhance Cancer Progression in Pancreatic Cancer Scientists aimed to examine the clinical significance, biological roles, and molecular mechanism of Rab11a in pancreatic cancer progression. [Tumour Biol] Abstract Investigators used four pancreatic ductal adenocarcinoma cell lines and two pancreas cancer-associated fibroblasts, the expression of insulin-like growth factor-1 (IGF1) and IGF1 receptor (IGF1R) was evaluated. [PLoS One] Full Article The role of DIX domain containing 1 (DIXDC1) in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, researchers investigated the role and prognostic value of DIXDC1 in the development of human PDAC. [Hum Pathol] Abstract RACK1 Overexpression Associates with Pancreatic Ductal Adenocarcinoma Growth and Poor Prognosis Receptor for activated protein kinase C (RACK1) was highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines and significantly associated with multiple clinicopathological factors. Univariate and multivariate analyses showed that high RACK1 expression was suggested to be an independent prognostic factor for PDAC patients’ survival. [Exp Mol Pathol] Abstract | |
| |
REVIEWSCancer, Obesity, Diabetes, and Antidiabetic Drugs: Is the Fog Clearing? Evidence supports the hypothesis that obesity increases the risks of both type 2 diabetes mellitus (T2DM) and certain cancers. Further complexity arises from controversial evidence that specific drugs used in the treatment of T2DM increase or decrease cancer risk or influence cancer prognosis. The authors review the current evidence from studies that have addressed these relationships, and summarize the methodological challenges that are frequently encountered in such research. [Nat Rev Clin Oncol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
INDUSTRY NEWSBioLineRx Ltd. announced the signing of a collaboration agreement with The University of Texas MD Anderson Cancer Center for the investigation of BL-8040 in combination with KEYTRUDA® in pancreatic cancer. [BioLineRx Ltd.] Press Release Mayo Clinic and Arizona State University’s research leadership announced the launch of a new grant program that will team up research scientists and clinicians from both institutions to develop transformative solutions for patients. [Mayo Clinic] Press Release Can Early Life Exposure to Pollutants Predispose for Disease University of Massachusetts Amherst has received a five-year, $1.7 million grant from the National Institute of Environmental Health Sciences for a multi-level study of early life exposure to environmental contaminants and aberrant pancreas development, which may predispose one to diabetes. [University of Massachusetts Amherst] Press Release | |
| |
POLICY NEWSBeyond CRISPR: A Guide to the Many Other Ways to Edit a Genome The zeal with which researchers jumped on a possible new gene-editing system called NgAgo earlier this year reveals an undercurrent of frustration with CRISPR–Cas9 — and a drive to find alternatives. “It’s a reminder of how fragile every new technology is,” says George Church, a geneticist at Harvard Medical School in Boston, Massachusetts. [Nature News] Editorial The FDA Is Prohibited from Going Germline A potentially renewable provision of the Consolidated Appropriation Act of 2016 forestalling the prospect of human germline modification was signed into law on December 18th, 2015. The provision has since been incorporated again into the House and Senate appropriation bills for the fiscal year. [ScienceInsider] Editorial US Agency Lifts Ban on Funding Human–Animal Hybrids Researchers in the United States will soon be able to resume creating chimaera-based projects. [Nature News] Editorial
| |
EVENTSNEW Genome Editing for Gene and Cell Therapy, a Herrenhausen Symposium Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Fellow – Genome Regulation and Diabetes (Imperial College London) Research Histotechnologist I (Fred Hutchinson Cancer Research Center) Post-Doctoral Scientist – Pancreatic Beta Cell Biology (Lilly) Postdoctoral Researcher – Breast, Prostate, and Pancreatic Cancer (MD Anderson Cancer Center) Research Program Manager – Pancreatic Cancer (University of Cambridge) Postdoctoral Fellow – Pancreatic Cancer Biology (New York University School of Medicine) Principal Investigator – Tenure Track Position (National Institutes of Health) Postdoctoral Fellowship – Various Projects (University of Pittsburgh) Postdoctoral Fellow – Pancreatic Cancer Metabolism (Thomas Jefferson University) Postdoctoral Fellows – Various Positions (Oregon Health & Science University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Pancreatic Cell News Volume 7.31 | Aug 9 2016