Pancreatic Cell News 7.34 August 30, 2016 | |
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TOP STORYγδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation Inflammation is paramount in pancreatic oncogenesis. Scientists identified a uniquely activated γδT cell population, which constituted 40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma. [Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISAldehyde Dehydrogenase 1a3 Defines a Subset of Failing Pancreatic β Cells in Diabetic Mice Investigators isolated and functionally characterized failing β cells from various experimental models of diabetes and report a striking enrichment in the expression of aldehyde dehydrogenase 1 isoform A3 (ALDH+) as β cells become dedifferentiated. Flow-sorted ALDH+ islet cells demonstrate impaired glucose-induced insulin secretion, are depleted of Foxo1 and MafA, and include a Neurogenin3-positive subset. [Nat Commun] Full Article Endothelial cells play an essential role in pancreatic organogenesis. Scientists hypothesized that effective in vitro interactions between human microvascular endothelial cells and human pluripotent stem cells results in the generation of functional pancreatic beta cells. [Diabetologia] Abstract GPR55-Dependent Stimulation of Insulin Secretion from Isolated Mouse and Human Islets of Langerhans Investigators evaluated the effects of GPR55 ligands on intracellular calcium levels and insulin secretion from islets isolated from GPR55 knockout (GPR55-/-) mice, age-matched wildtype mice, and human pancreas. [Diabetes Obes Metab] Abstract MicroRNA-17-92 Cluster Regulates Pancreatic Beta-Cell Proliferation and Adaptation Scientists found that conditional deletion of miR-17-92 in mouse pancreatic beta-cells significantly reduces glucose tolerance and the first phase of insulin secretion, despite normal ad libitum fed and fasting glucose levels. Proliferation was down-regulated in pancreatic beta-cells after deleting miR-17-92. [Mol Cell Endocrinol] Abstract PANCREATIC CANCERScientists identified novel epigenetic regulators contributing to the biology of pancreatic ductal adenocarcinoma. [Clin Cancer Res] Abstract Investigators found elevated SULF2 in pancreatic ductal adenocarcinoma (PDAC) was associated with advanced tumor stage, vascular invasion, shorter interval to radiological progression and shorter overall survival. SULF2 may have roles as a prognostic biomarker and as a therapeutic target for patients with PDAC. [Br J Cancer] Abstract Researchers analyzed the antitumor effect of measles virus against pancreatic cancer. [Cancer Sci] Abstract Hedgehog Pathway Overexpression in Pancreatic Cancer Is Abrogated by New-Generation Taxoid SB-T-1216 Scientists investigated the prognostic importance of Hedgehog signaling pathway in pancreatic cancer patients who underwent a radical resection. [Pharmacogenomics J] Abstract MiR-145 Functions as a Tumor Suppressor via Regulating Angiopoietin-2 in Pancreatic Cancer Cells Scientists investigated the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. [Cancer Cell Int] Full Article | |
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REVIEWSBeta Cell Differentiation Status in Type 2 Diabetes The authors discuss current knowledge of determinants of beta cell fate in the context of understanding its relevance to disease process in T2D, and also considers the impact of a diabetogenic environment (hyperglycaemia, hypoxia, inflammation and dyslipidaemia) on the expression of genes involved in maintenance of beta cell identity. [Diabetes Obes Metab] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSInsulin Pill Could Make Diabetes Treatment ‘Ouchless’ Scientists have developed a new way of administering medicine orally with tiny vesicles that can deliver insulin where it needs to go without a shot. [Press release from American Chemical Society discussing research presented at 252nd National Meeting & Exposition of the American Chemical Society, Philadelphia] Press Release | |
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INDUSTRY NEWSCenter for Diabetes Translation Research Gets $3.7 Million Grant The Center for Diabetes Translation Research has been awarded $3,735,000 to continue five years of funding by the National Institute for Diabetes and Digestive and Kidney Diseases, a National Institutes of Health institute. [Washington University, St. Louis] Press Release Takara Bio USA, Inc. announced the launch of fully differentiated, Cellartis hiPS beta cells for research use. These cells are well characterized and can provide physiologically relevant responses that are beneficial for modeling diabetes and beta-cell function, encouraging breakthroughs that advance research in personalized and regenerative medicine. [Takara Bio USA, Inc] Press Release Interpace Diagnostics Launches New Product for Pancreatic Cancer Testing Interpace Diagnostics Group has launched a new version of their AccuCEA™ product called “Insights” for Gastroenterologists who focus on diagnosing and treating pancreatic cancer. [Interpace Diagnostics Group (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSTo make replication studies more useful, researchers must make more of them, funders must encourage them and journals must publish them. [Nature] Editorial New Leader of NIH’s Research Watchdog Faces Staff Revolt Kathryn Partin, who took the helm of ORI in December 2015, has launched a top-to-bottom review of the office, which has been criticized for moving too slowly and meting out sanctions that lack teeth. [ScienceInsider] Editorial South African Academics Warn of Universities on the Brink More than 1,200 South African academics are warning that the country’s university system is at a tipping point as a result of chronic underfunding. [Nature] Editorial
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EVENTSNEW 6th Annual Cell & Gene Therapy BioProcessing & Commercialization Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESVice President – Legacy Research Institute (Legacy Health) Postdoctoral Researcher – Translational Cancer Discovery (Institute of Cancer Research) Product Specialist – Oncology (Celgene Corporation) Postdoctoral Fellow – Control and Estimation for the Artificial Pancreas (Mc Gill University) Postdoctoral Fellow – Pancreatic Stem Cell Biology (University of Southern California) Research Histotechnologist I (Fred Hutchinson Cancer Research Center) Postdoctoral Researcher – Breast, Prostate, and Pancreatic Cancer (MD Anderson Cancer Center) Postdoctoral Fellow – Pancreatic Cancer Biology (New York University School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Pancreatic Cell News Volume 7.34 | Aug 30 2016