Pancreatic Cell News 7.35 September 6, 2016 | |
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TOP STORYThrombospondin 1 Protects Pancreatic β-Cells from Lipotoxicity via the PERK–NRF2 Pathway Researchers showed a critical novel role for thrombospondin 1 (THBS1) in β-cell survival during lipotoxic stress in rat, mouse and human models. THBS1 acts from within the endoplasmic reticulum to activate PERK and NRF2 and induce a protective antioxidant defense response against palmitate. [Cell Death Differ] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISStudying rats fed high cholesterol diet and a pancreatic β-cell line, the authors aimed to determine the mechanisms by which quercetin protects against cholesterol-induced pancreatic β-cell dysfunction and impairments in glycemic control. [Redox Biol] Abstract C4b-Binding Protein Protects β-Cells from Islet Amyloid Polypeptide Induced Cytotoxicity Addition of monomeric islet amyloid polypeptide (IAPP) to a rat insulinoma cell line (INS-1) resulted in decreased cell viability, which was restored in the presence of physiological concentrations of C4b-binding protein (C4BP). Treatment of INS-1 cells and primary rat islets with IAPP also diminished their ability to secrete insulin upon stimulation with glucose, which was reversed in the presence of C4BP. [J Biol Chem] Abstract | Full Article EGFR Signaling Regulates Beta Cell Proliferation in Adult Mice Researchers showed that epidermal growth factor receptor 1 (EGFR) was significantly upregulated in the islets of C57BL/6 mice after 50% partial pancreatectomy, a model for workload-induced β cell proliferation. [J Biol Chem] Abstract | Full Article Scientists optimized insulin production using lentiviral transduced canine mesenchymal stromal cells aiming to evaluate their ability for use as surrogate beta cells. [J Gene Med] Abstract Investigators demonstrated that hyperplasic pancreatic islets from prediabetic mice fed a high-fat diet for 60 days displayed nuclear translocation of active β-catenin associated with significant increases in protein content and gene expression of β-catenin as well as of cyclins D1, D2 and c-Myc but not of Tcf7l2. [Biochem Biophys Res Commun] Abstract PANCREATIC CANCERInvestigators showed for the first time that TUFT1 is overexpressed in pancreatic cancer (PC) tissues compared with adjacent normal pancreas tissues, and TUFT1 expression is significantly associated with lymph node metastasis and advanced PC stage. [Cancer Lett] Abstract To assess a putative role of MEIS1 in the progression of pancreatic ductal adenocarcinoma, MEIS1 overexpressing pancreatic cancer cell lines were generated by retroviral gene delivery and assessed for proliferation and migration. [Mol Carcinog] Abstract Calreticulin Is Highly Expressed in Pancreatic Cancer Stem-Like Cells Scientists aimed to identify a biomarker of pancreatic cancer stem-like cells (P-CSLCs). P-CSLC-enriched population was generated from pancreatic cancer cell lines using their previously reported method and its protein expression profile was compared with that of parental cells by two-dimensional electrophoresis and tandem mass spectrometry. [Cancer Sci] Abstract Thr authors explored the molecular functional of microRNA-127 in regulating pancreatic cancer development both in vitro and in vivo. [Tumor Biol] Abstract Researchers determined whether curcumin can suppress H2O2-induced tumor invasive and migratory abilities. Human pancreatic cancer BxPC-3 and Panc-1 cells were exposed to H2O2 with or without curcumin or N-acetylcysteine. [Oncol Rep] Abstract | |
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REVIEWSImpact of Islet Architecture on β-Cell Heterogeneity, Plasticity and Function Identifying phenotypic and functional markers to discriminate distinct β-cell subpopulations and the mechanisms underpinning their regulation is warranted to advance current knowledge of β-cell function and to design novel regenerative strategies that target subpopulations of β cells. [Nat Rev Endocrinol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSEndocrine Society Announces 2017 Laureate Award Winners The Endocrine Society announced it has selected 14 leaders in the endocrinology field as winners of the organization’s prestigious 2017 Laureate Awards. [Endocrine Society] Press Release Scripps Health and The University of Texas MD Anderson Cancer Center have reached a partnership agreement to create Scripps MD Anderson Cancer Center, a comprehensive and clinically integrated cancer care program in San Diego that will provide adult cancer patients greater access to the most advanced oncology care available throughout Southern California. [Scripps Health] Press Release | |
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POLICY NEWSCongress Returns, with a Long Science To-Do List and Not Much Time Congress returns from a 7-week summer break with a lengthy list of unfinished business, some of great interest to the U.S. research community—and just a few weeks to tackle it. [ScienceInsider] Editorial Turkey Sacks Thousands of University Staff Turkey’s government has sacked 2,346 university staff for suspected ties to July’s attempted military coup in the country. The sackings, announced in a 1 September decree as part of a wider purge of 40,000 civil servants, are the first of an expected wave of dismissals under powers granted by state-of-emergency rules following the coup. [Nature News] Editorial
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EVENTSNEW Keystone Symposium: TGFβ in Immunity, Inflammation and Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cancer Research (Sanford Burnham Prebys Medical Discovery Institute) NEW Assistant Scientist – Diabetes Research (University of Miami) Vice President – Legacy Research Institute (Legacy Health) Postdoctoral Fellow – Pancreatic Stem Cell Biology (University of Southern California) Research Histotechnologist I (Fred Hutchinson Cancer Research Center) Postdoctoral Researcher – Breast, Prostate, and Pancreatic Cancer (MD Anderson Cancer Center) Postdoctoral Fellow – Pancreatic Cancer Biology (New York University School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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