Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News| Pancreatic Cell News 7.39 October 4, 2016 | |
 | |
| |
TOP STORY24-Hydroxycholesterol Participates in Pancreatic Neuroendocrine Tumor Development The authors showed that the 24S-hydroxycholesterol (24S-HC) oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1–T-antigen 2 (RIP1-Tag2) pNET formation. They reported that Cyp46a1 overexpression requires hypoxia inducible factor-1a. They showed that pharmacologic blockade and genetic inactivation of 24S-HC delays angiogenic switch and therefore tumor formation in RIP1-Tag2. [Proc Natl Acad Sci USA] Abstract | |
| |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISInvestigators showed adipose triglyceride lipase (ATGL) in beta cells regulates insulin secretion via the production of signaling monoacylglycerols. Decreased insulinemia due to lowered glucose-induced insulin secretion protects B-Atgl-KO mice from diet-induced obesity, improves insulin sensitivity, increases lipid mobilisation from white adipose tissues and causes brown adipose tissue activation. [Diabetologia] Full Article CD99 as Surface Anchor for Human Islet Endocrine Cell Purification Scientists investigated CD99’s applicability as anchor for islet endocrine cell purification. They studied CD99 gene and protein expression by microarray, LC-MS/MS, Western blotting, flow cytometry and immunofluorescence and developed a protocol for magnetic bead-mediated beta cell enrichment from human pancreas digests using available anti-CD99 antibodies. [J Tissue Eng Regen Med] Abstract A Single-Cell Transcriptome Atlas of the Human Pancreas The authors identified cell type-specific transcription factors and a subpopulation of REG3A-positive acinar cells. They also showed that CD24 and TM4SF4 expression can be used to sort live alpha and beta cells with high purity. [Cell Syst] Full Article | Graphical Abstract PANCREATIC CANCERThe authors found that HIF-1α-induced TWIST overexpression promoted tumor cell growth in vitro and epithelial-mesenchymal transition under a hypoxic condition via TWIST interaction with Ring1B and EZH2. [Cancer Lett] Abstract Scientists investigated the therapeutic potential of phycocyanin as an anti-PDA agent in vivo and in vitro. Phycocyanin, a natural product purified from Spirulina, effectively inhibits the pancreatic cancer cell proliferation in vitro and xenograft tumor growth in vivo. [Sci Rep] Full Article Interplay between Cell Cycle and Autophagy Induced by Boswellic Acid Analog Scientists investigated the role of autophagy induced by boswellic acid analog BA145 on cell cycle progression in pancreatic cancer cells. BA145 induced robust autophagy in pancreatic cancer cell line PANC-1 and exhibited cell proliferation inhibition by inducing cells to undergo G2/M arrest. [Sci Rep] Full Article Molecular Signatures of Mu Opioid Receptor and Somatostatin Receptor 2 in Pancreatic Cancer Researchers showed that while mu opioid receptor and somatostatin receptor 2 did not colocalize in healthy pancreatic cells or matching healthy patient tissues, the pair did significantly colocalize in pancreatic cancer cells, multicellular tumor spheroids, and cancerous patient tissues. Moreover, this association in pancreatic cancer cells correlated with functional cross-talk and increased metastatic potential of cells. [Mol Biol Cell] Full Article CTHRC1 Promotes Angiogenesis by Recruiting Tie2-Expressing Monocytes to Pancreatic Tumors CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. Researchers identified a novel role of CTHRC1 as a potent endothelial activator that promotes angiogenesis by recruiting bone marrow-derived cells to the tumor microenvironment during tumorigenesis. [Mol Med] Full Article Numb/Notch Signaling Pathway Modulation Enhances Human Pancreatic Cancer Cell Radiosensitivity Investigators evaluated whether repression of the Numb/Notch signaling pathway affects the radiosensitivity of human pancreatic cancer cell lines. [Tumor Biol] Abstract | |
| |
| |
REVIEWSAdvances in β Cell Replacement and Regeneration Strategies for Treating Diabetes The authors provide an overview of progress made toward β cell replacement and regeneration and discuss promises and challenges for clinical implementation of these strategies. [J Clin Invest] Abstract The Emerging Role of Cdk5 in Cancer The authors discuss the contribution of Cdk5 to molecular mechanisms that confer upon tumors the ability to grow, proliferate, and disseminate to secondary organs, as well as resistance to chemotherapies. [Trends Cancer] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
INDUSTRY NEWSDr. Allen Eaves of STEMCELL Technologies Inc. Named EY Entrepreneur of the Year™ Pacific 2016 Dr. Allen Eaves, Chairman, President and Chief Executive Officer of STEMCELL Technologies, a global biotechnology company that supplies tools and services to enable life science research, is this year’s Entrepreneur Of The Year Pacific winner. [STEMCELL Technologies(Ernst & Young)] Press Release A New Model for Pancreatic Cancer Clinical Research A new model for cancer clinical trials was launched Tuesday for patients with pancreatic cancer, one of the most deadly types of cancer. Called “Precision Promise,” this new nationwide precision-medicine endeavor seeks to turn the concept of clinical trials on its head: Rather than finding participants for a given experimental treatment study, the approach finds the right treatment for a given patient at a given time. [Fred Hutchinson Cancer Research Center] Press Release Seven UCSF Scientists Receive NIH ‘Blue-Sky’ Research Awards The National Institutes of Health (NIH) has awarded grants to seven UC San Francisco scientists to pursue innovative approaches to major contemporary challenges in biomedical research. [UCSF] Press Release FDA Approves First Automated Insulin Delivery Device for Type 1 Diabetes The U.S. Food and Drug Administration approved Medtronic’s MiniMed 670G hybrid closed looped system, the first FDA-approved device that is intended to automatically monitor glucose and provide appropriate basal insulin doses in people 14 years of age and older with type 1 diabetes. [U.S. Food and Drug Administration] Press Release Riptide Bioscience, Inc. announced the execution of a Cooperative Research and Development Agreement with the National Cancer Institute. The agreement carries a three-year term and is entitled, Evaluation of Riptide Bioscience’s Proprietary Peptide RP-182 in Preclinical Studies for the Treatment of Pancreatic Cancer. [Riptide Biosciences (PR Newswire Association LLC.)] Press Release | |
| |
POLICY NEWSDemocratic Databases: Science on GitHub Scientists are turning to a software–development site to share data and code. [Nature Toolbox] Editorial Biologists Plan Scoring System for Antibodies Biomedical experts plan to create a scoring system that will help researchers choose reliable antibodies for their experiments. The only problems: figuring out how such a ranking would work — and getting manufacturers to adopt the standard. [Nature News] Editorial UK Bioethicists Eye Designer Babies and CRISPR Cows From designer babies to engineered mosquitoes, advances in genome-editing technologies such as CRISPR–Cas9 have raised the possibility of tremendous scientific advances — and serious ethical concerns. [Nature News] Editorial
| |
EVENTSNEW Stem Cells in Drug Discovery NEW Stem Cells and Regenerative Medicine 2nd International Congress Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Pancreatic Cancer (University of Liège) Postdoctoral Position – Immunology of Diabetes (INSERM) Vice President – Pancreatic Cancer Disease Lead (Celgene Corporation) Postdoctoral Research Fellow – Pancreas Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Fellowship- Pacreatic Islet Biology (University of Michigan Medical School) Chair of Medical Biology (Masaryk University) Postdoctoral Position – Cancer Research (Sanford Burnham Prebys Medical Discovery Institute) Assistant Scientist – Diabetes Research (University of Miami) Postdoctoral Fellow – Pancreatic Stem Cell Biology (University of Southern California) Research Histotechnologist I (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Pancreatic Cell News Volume 7.39 | Oct 04 2016
