Pancreatic Cell News 7.40 October 11, 2016 | |
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TOP STORYSingle-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas Scientists applied mass cytometry technology to measure all major islet hormones, proliferative markers, and readouts of signaling pathways involved in proliferation at single-cell resolution. Using this technology, they simultaneously examined baseline proliferation levels of all endocrine cell types from birth through adulthood, as well as in response to the mitogen harmine. [Cell Metab] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe authors applied optical projection tomography and ultramicroscopy imaging to extract information about individual islet β-cell volumes throughout the volume of ob/ob pancreas between 4 and 52 weeks of age. [Sci Rep] Full Article The Angiotensin-(1–7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo The ACE2/angiotensin (Ang)-(1-7)/Mas axis of the renin-angiotensin system often opposes the detrimental effects of the ACE/AngII/AT1 axis and has been associated with beneficial effects on glucose homeostasis, while underlying mechanisms are mostly unknown. Scientists investigated the effects of Ang-(1-7) and its receptor Mas on β-cell function. [Endocrinology] Abstract | Full Article Researchers used zinc oxide nanoparticles (ZnONPs) and a standard antidiabetic drug to restore the function and structure of beta cells in a rat model of Type-2 diabetes and compare the effects of a DPP-IV inhibitor with or without ZnONPs using a model of Type-2 diabetes. [Biomed Pharmacother] Abstract PANCREATIC CANCERScientists analyzed the pancreatic ductal adenocarcinoma proteomic stromal signature and identified a contribution of the annexin A6/LDL receptor-related protein 1/thrombospondin 1 complex in tumor cell crosstalk. [J Clin Invest] Full Article Investigators examined the phosphorylation status of interleukin-1 receptor-associated kinase (IRAK4), the master regulator of toll-like receptors signaling, in pancreatic ductal adenocarcinoma cell lines, in surgical samples and commercial tissue microarray. [Clin Cancer Res] Abstract | Full Article HDAC1 and HDAC2 Integrate the Expression of p53 Mutants in Pancreatic Cancer Researchers showed that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the expression of p53 mutants in human and genetically defined murine pancreatic cancer cells. [Oncogene] Abstract The authors described that siRNA-mediated silencing of runt-related transcription factor 2 (RUNX2) improves anti-cancer drug GEM sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the augmentation of p53 family TAp63-dependent cell death pathway. In this manuscript, they have extended their study to p53-mutated human pancreatic cancer Panc-1 cells. [Oncotarget] Full Article Investigators showed that co-high expression of both PLD1 and Sp1 confers the poorest prognosis for the patients, and that their simultaneous high expression is an independent prognostic factor. They also found Sp1 to be elevated in the disease, correlating with vascular invasion. [Oncotarget] Full Article The alternatively spliced tissue factor (asTF)-overexpressing pancreatic ductal adenocarcinoma cell line Pt45.P1/asTF+ and its parent cell line Pt45.P1 were tested for growth and mobility under normoxic conditions that model early-stage tumors, and in the hypoxic environment of late-stage cancers. [Lab Invest] Abstract | |
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REVIEWSEndoplasmic Reticulum Stress in Beta Cells and Autoimmune Diabetes The authors highlight recent findings on endoplasmic reticulum (ER) stress in β cells and development of type 1 diabetes and introduce potential new treatments targeting the ER to combat this disorder. [Curr Opin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSMerrimack Pharmaceuticals, Inc. announced final results from the Phase III NAPOLI-1 study validating the use of ONIVYDE® (irinotecan liposome injection) in combination with fluorouracil and leucovorin, which represents a new standard of care for patients with metastatic pancreatic ductal adenocarcinoma following treatment with gemcitabine-based therapy. [Press release from Merrimack Pharmaceuticals, Inc. discussing research presented at European Society for Medical Oncology 2016 Congress, Copenhagen] Press Release | |
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INDUSTRY NEWSDebiopharm Groupâ„¢ presented the ‘JCA-Mauvernay Award’ to Doctors Hidewaki Nakagawa from the RIKEN Center for Integrated Medical Sciences for his basic research on Molecular Diagnosis and Treatment of Cancers Using Genome Sequencing and Genome-wide Association Study and Hiroyuki Seimiya from the Division of Molecular Biotherapy, Cancer Chemotherapy Center of the Japanese Foundation for Cancer Research for his applied research on Telomere Maintenance System as an Anticancer Therapeutic Target. [Debiopharm Groupâ„¢] Press Release Houston Methodist Receives $9 Million Federal Grant to Study the Physics of Cancer Immunotherapy The Houston Methodist Research Institute has been awarded a $9 million grant from the National Cancer Institute to establish a research center focused on the physics of cancer immunotherapy. [Houston Methodist] Press Release | |
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POLICY NEWSA recruitment and retention program launched by the Howard Hughes Medical Institution in Chevy Chase, Maryland, aims to reduce barriers for women and under-represented minorities who seek academic-research careers in the life sciences. [Nature Careers] Editorial Investors Flee as Firm Scraps RNA-Interference Drug Candidate A prominent developer of drugs that use RNA interference has abandoned one of its leading candidates amid safety concerns — sending a fresh wave of worry through a field that has long struggled to bring treatments to market. [Nature News] Editorial The Many Shades of European Postdoc Funding Finding the right grant or fellowship to fund a postdoc can be a challenge, and the situation is all the more complex in Europe, where academic systems, career prospects, and living costs vary widely among countries. [Science Careers] Editorial
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EVENTSNEW The Biology of Regenerative Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Pancreatic Cancer (Van Andel Research Institute) Postdoctoral Fellowship – Pancreatic Cancer (University of Liège) Postdoctoral Position – Immunology of Diabetes (INSERM) Vice President – Pancreatic Cancer Disease Lead (Celgene Corporation) Postdoctoral Research Fellow – Pancreas Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Fellowship- Pacreatic Islet Biology (University of Michigan Medical School) Chair of Medical Biology (Masaryk University) Postdoctoral Position – Cancer Research (Sanford Burnham Prebys Medical Discovery Institute) Assistant Scientist – Diabetes Research (University of Miami) Postdoctoral Fellow – Pancreatic Stem Cell Biology (University of Southern California) Research Histotechnologist I (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Pancreatic Cell News Volume 7.40 | Oct 11 2016