Pancreatic Cell News Volume 7.41 | Oct 18 2016

TOP STORY

A Renewed Model of Pancreatic Cancer Evolution Based on Genomic Rearrangement Patterns

Scientists tracked changes in DNA copy number and their associated rearrangements in tumor-enriched genomes and found that pancreatic cancer tumorigenesis is neither gradual nor follows the accepted mutation order. [Nature] Abstract | Press Release

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

MicroRNAs miR-23a-3p, miR-23b-3p and miR-149-5p Regulate the Expression of Pro-Apoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic Beta Cells

Investigators performed a microRNA expression profile on human islet preparations exposed to the cytokines IL-1β+IFN-γ. [Diabetes] Abstract

Hepcidin Knockout Mice Spontaneously Develop Chronic Pancreatitis Due To Cytoplasmic Iron Overload in Acinar Cells

Given that hepcidin-resistant ferroportin mutant mice display exocrine pancreas dysfunction, the authors analyzed pancreata of aging hepcidin knockout mice. [J Pathol] Abstract

Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling

The authors showed that retinol dehydrogenase-10, a key enzyme in embryonic retinoic acid production, has important functions in pancreas organogenesis and endocrine cell differentiation. [Endocrinology] Abstract | Full Article

PANCREATIC CANCER

Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

The authors reported that tumor associated macrophages and myofibroblasts directly support chemoresistance of pancreatic cancer cells by secreting insulin-like growth factors 1 and 2 (IGF), which activate Insulin/IGF receptors on pancreatic cancer cells. [Cancer Res] Abstract | Full Article

Amino Acid Transporter SLC6A14 Is a Novel and Effective Drug Target for Pancreatic Cancer

Researchers wanted to find out which amino acid transporters are upregulated in pancreatic cancer and whether any of these transporters has potential as a drug target for this deadly disease. [Br J Pharmacol] Abstract | Full Article | Press Release

Antitumor Activity of Curcumin Is Involved in Down-Regulation of YAP/TAZ Expression in Pancreatic Cancer Cells

Researchers determined the molecular basis of curcumin-induced cell proliferation inhibition in pancreatic cancer cells. [Oncotarget] Full Article

Acetyl-CoA Carboxylase Inhibitors Attenuate WNT and Hedgehog Signaling and Suppress Pancreatic Tumor Growth

Investigators reported that inhibition of acetyl-CoA carboxylase by a small molecule inhibitor, BAY ACC002, blocked WNT3A lipidation, secretion, and signaling. [Oncotarget] Full Article

Paracrine IL-6 Signaling Mediates the Effects of Pancreatic Stellate Cells on Epithelial-Mesenchymal Transition via Stat3/Nrf2 Pathway in Pancreatic Cancer Cells

To study the mechanism of pancreatic ductal adenocarcinoma progression to metastasis, scientists investigated the role of pancreatic stellate cells-secreted interleukin (IL)-6 in activating epithelial-mesenchymal transition and the involvement of Nrf2 in this process. [Biochim Biophys Acta] Abstract

A Roadmap of the Generation of Neoantigens as Targets of the Immune System in Type 1 Diabetes

This review compiles post-transcriptional and post-translational modifications involved in the generation of beta cell neoantigens and proposes a reconstruction of the sequence of events connecting environmental changes and autoimmunity. [Curr Opin Immunol] Full Article

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Exclusive License Agreement with Astrazeneca in Respect of Byetta and Bydureon

AstraZeneca has agreed to grant an exclusive license to Hongkong Sansheng for the commercialization of diabetes drugs Bydureon and Byetta. Hongkong Sansheng will make an upfront payment of US$50 million and milestone payments of a maximum of US$50 million to AstraZeneca. [3SBio Inc.] Press Release

NYU Langone’s Research Leader Receives Prestigious Award From The National Cancer Institute

Cancer researcher Dafna Bar-Sagi, PhD, has been named a recipient of the Outstanding Investigator Award, a highly prestigious honor presented by the National Cancer Institute. [NYU Langone Medical Center (PR Newswire Association LLC)] Press Release

Biden’s Moonshot Cancer Plan Calls for More Data Sharing

Vice President Joe Biden released his vision for doubling progress against cancer over 5 years. It includes numerous policy recommendations and a laundry list of projects by the National Cancer Institute and other federal agencies that would require additional funding. [Science Insider] Editorial

U.S. and Cuban Biomedical Researchers are Free to Collaborate

The U.S. Department of the Treasury has authorized U.S. scientists to freely collaborate with Cuban counterparts on everything from cancer therapies to combating the Zika virus. [Science Insider] Editorial

Leading Scientists Clash over Sweeping UK Research Reforms

UK government plans to shake up the way the country’s research is funded are causing dissent among leading British scientists. At the Science Media Centre in London, some of the country’s most eminent researchers clashed over the draft laws, which involve bringing together several existing funding bodies — including the UK’s seven research councils — into one central funder called UK Research and Innovation. [Nature News] Editorial

Safety Concerns Blight Promising Cancer Therapy

A groundbreaking treatment that arms immune cells called T cells to battle cancer is barrelling towards regulators, fuelled by unprecedented clinical success and investor exuberance. [Nature News] Editorial

NEW VII InterAmerican Oncology Conference
October 5-6, 2017
Buenos Aires, Argentina

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Cancer and Immunometabolism (The University of Michigan)

Postdoctoral Fellowship – Pancreatic Cancer (University of Liège)

Postdoctoral Position – Immunology of Diabetes (INSERM)

Vice President – Pancreatic Cancer Disease Lead (Celgene Corporation)

Postdoctoral Research Fellow – Pancreas Cancer (Fred Hutchinson Cancer Research Center)

Chair of Medical Biology (Masaryk University)

Postdoctoral Position – Cancer Research (Sanford Burnham Prebys Medical Discovery Institute)

Assistant Scientist – Diabetes Research (University of Miami)

Postdoctoral Fellow – Pancreatic Biology (Toronto General Research Institute & McEwen Centre for Regenerative Medicine)

Postdoctoral Fellow – Pancreatic Stem Cell Biology (University of Southern California)

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