Pancreatic Cell News 8.02 January 17, 2017 | |
| |
TOP STORYInvestigators report large-scale reprogramming of chromatin modifications during the natural evolution of distant metastasis in pancreatic ductal adenocarcinoma. [Nat Genet] Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISScientists found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous IL-1β signaling in mice during refeeding and obesity diminished the concentration of insulin in plasma. [Nat Immunol] Abstract FGF21 Is an Exocrine Pancreas Secretagogue The authors showed that FGF21 stimulates digestive enzyme secretion from pancreatic acinar cells through an autocrine/paracrine mechanism that requires signaling through a tyrosine kinase receptor complex composed of an FGF receptor and β-Klotho. [Cell Metab] Abstract | Graphical Abstract Researchers obtained double knockout pigs (DKO) lacking α(1,3)-galactose and N-glycolylneuraminic acid (Neu5Gc). As Neu5Gc-/- mice exhibit glycemic dysregulations and pancreatic β-cell dysfunctions, they evaluated islet function and glucose metabolism regulation in DKO pigs. [Diabetes] Abstract Glucose and Fatty Acids Synergistically and Reversibly Promote Beta Cell Proliferation in Rats Scientists tested the hypothesis that glucose and NEFA synergistically and reversibly promote beta cell proliferation in the context of nutrient-induced insulin resistance. [Diabetologia] Abstract Researchers found that C. edulis extract (CE) is protective against diabetes in mice. The treatment of hyperglycemic and hyperlipidemic apolipoprotein E −/− mice with a high dose of CE reduced serum glucose by 28.84% and serum total cholesterol by 17.34% and increased insulin release. They also found that CE significantly enhanced insulin secretion in a glucose-independent manner in hamster pancreatic β cells. [Sci Rep] Full Article Development of a Novel Model of Hypertriglyceridemic Acute Pancreatitis in Mice Investigators established a novel mice model of hypertriglyceridemic acute pancreatitis by poloxamer 407 combined with cerulein. [Sci Rep] Full Article PANCREATIC CANCERUpregulation of RET Induces Perineurial Invasion of Pancreatic Adenocarcinoma Using the transgenic Pdx-1-Cre/KrasG12D /p53R172H mouse model, the authors investigated the mechanism of neural invasion in pancreatic ductal adenocarcinoma . To detect tissue-specific factors that influence neural invasion by cancer cells, they characterized the perineurial microenvironment using a series of bone marrow transplantation experiments in transgenic mice expressing single mutations in the Cx3cr1, GDNF and CCR2 genes. [Oncogene] Abstract Researchers investigated the effect of ENO1 silencing on the modulation of cell morphology, adhesion to matrix substrates, cell invasiveness, and metastatic ability. [J Hematol Oncol] Full Article Cytokine stimulation of pancreatic cancer cells increased CCL28 secretion in epithelial tumor cells but not an immortalized activated human pancreatic stellate cell line. [Lab Invest] Abstract Scientists previously isolated a human pancreatic tumor-initiating cell line, KMC07, from a patient with acquired resistance to gemcitabine chemotherapy. To improve the anticancer effects of gemcitabine, they investigated the molecular mechanism of KMC07 cells’ resistance to gemcitabine. [Pancreas] Abstract Researchers investigated the influence of palmitic acid (PA) on the invasive capacity of human pancreatic cancer cells AsPC-1. Using specific inhibitors, they found that PA stimulation of these tumor cells induced a TLR4-mediated cell invasion. [Biochem Biophys Res Commun] Abstract | |
| |
REVIEWSThe Molecular and Morphogenetic Basis of Pancreas Organogenesis The authors review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. [Semin Cell Dev Biol] Abstract Apportioning Blame: Autoreactive CD4+ and CD8+ T Cells in Type 1 Diabetes Researchers summarize recent studies clarifying the role played by both sets of autoreactive T lymphocytes in type 1 diabetes (T1D), discuss the targets recognized by these cells and their phenotype in T1D patients. [Arch Immunol Ther Exp (Warsz)] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
INDUSTRY NEWSCity of Hope Sets New Goal for Type 1 Diabetes Cure A cure for type 1 diabetes (T1D) in six years is the new goal of City of Hope’s Diabetes and Metabolism Research Institute. Through the generosity of the Wanek family and gifts from anonymous donors, the institution will be able to devote more than $50 million over the next six years to an innovative research effort that seeks to find a cure for T1D. [City of Hope] Press Release Fiasp® (Fast-Acting Insulin Aspart) Approved in Europe Novo Nordisk announced that the European Commission has granted marketing authorization for Fiasp® for the treatment of diabetes in adults. [Novo Nordisk A/S] Press Release BioLineRx Ltd. announced the initiation of a second Phase IIa trial investigating BL-8040 in combination with KEYTRUDA®, MSD’s anti-PD-1 therapy, in patients with metastatic pancreatic cancer. [BioLineRx Ltd.] Press Release ProtoKinetix, Incorporated announced that the Governors of the University of Alberta have submitted an Investigational Testing Authorization application to commence clinical studies in Canada. This authorization will allow the clinical trial group to enroll Canadian patients into the study. [Protokinetix Inc.] Press Release MorphoSys Partner to Start Phase II Trial with Bimagrumab in Obese Patients with Type 2 Diabetes MorphoSys AG announced that its partner Novartis will conduct a Phase II clinical trial of the HuCAL antibody bimagrumab in obese patients with type 2 diabetes. [MorphoSys AG] Press Release | |
| |
POLICY NEWSCroatia’s Science Minister Rejects Calls to Resign amid Plagiarism Scandal In a plagiarism scandal in Croatia, the country’s highest-level research ethics committee is clashing with its science minister — who says he won’t step down after the committee found he had copied another scholar’s work. Scientists say the case raises questions about academic integrity at the top of a research system that is already riven with misconduct allegations. [Nature News] Editorial European Commission Clears Up Questions on Orphan Drug Regulation Following a public consultation in November 2015, the European Commission has released a new communication intended to clarify some lingering questions about the EU’s Orphan Regulation. The consultation sought to address five issues that have arisen since the Orphan Regulation came into effect in January 2000. [Regulatory Affairs Professionals Society] Editorial Surprising Contenders Emerge for Trump’s NIH Chief Could US president-elect Donald Trump be close to choosing a leader for the National Institutes of Health (NIH)? Current NIH chief Francis Collins and Representative Andy Harris (Republican, Maryland), both front-runners for job, met separately with Trump, as did billionaire surgeon Patrick Soon-Shiong. Several people familiar with the Collins and Harris meetings described them as job interviews. [Nature Breaking News] Editorial
| |
EVENTSNEW Gordon Research Conference – Cancer Nanotechnology Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Scientist – Protein Misfolding and Toxicity (The George Washington University) Senior Scientist – Pancreatic Cell Research (STEMCELL Technologies Inc.) Postdoctoral Research Fellow – Pancreatic Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Position – Pancreatic Cancer (University of Liege) Scientist – Insulin Secretion (Helmholtz Association) Principle Scientist – Translational Development (Celgene Corporation) Postdoctoral Researcher – Cell Biology (Northwestern University) Postdoctoral Researcher – Diabetes Research (Karolinska Institutet) Assistant Professor – Molecular Therapeutics (Dartmouth College/Geisel School of Medicine) Vice President – Pancreatic Cancer Disease Lead (Celgene Corporation) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Pancreatic Cell News Volume 8.02 | Jan 17 2017