Pancreatic Cell News 8.31 August 8, 2017 | |
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TOP STORYDevelopment of Autoimmune Pancreatitis Is Independent of CDKN1A/p21-Mediated Pancreatic Inflammation Investigators examined the role of p21-mediated inflammation in autoimmune pancreatitis (AIP). They intercrossed lymphotoxin overexpressing mice — a model to study AIP development — with p21-deficient mice. Furthermore, they characterized p21 expression in human AIP and non-AIP specimens. [Gut] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISNanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy Researchers demonstrated a nanoporous immunoprotective polymer thin film cell encapsulation device that can exclude immune molecules while allowing exchange of oxygen and nutrients necessary for in vitro and in vivo stem cell viability and function. [ACS Nano] Full Article | Graphical Abstract Scientists used long-term partial pancreatic duct ligation (PDL) as a model to study chronic pancreatitis-related diabetes. They found that long-term PDL induced significant β-cell dedifferentiation, followed by a time-dependent decrease in functional β-cell mass, all specifically in the ligated tail portion of the pancreas. [Diabetes] Abstract αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation Investigators showed that αE-catenin, a key component of adherens junctions, functions as a positive regulator of pancreatic islet cell lineage differentiation by repressing the sonic hedgehog pathway. [Cell Rep] Full Article | Graphical Abstract Researchers investigated the effects of S-equol on pancreatic β-cell function. β-Cell growth and insulin secretion were evaluated with male Institute of Cancer Research mice and isolated pancreatic islets from the mice, respectively. The mechanisms by which S-equol stimulated β-cell response were examined in INS-1 β-cells. [J Nutr] Abstract Insulin Receptor Signaling and Glucagon-Like Peptide 1 Effects on Pancreatic Beta Cells The authors investigated whether the protective effects of GLP-1 on beta cells were affected by altered insulin receptor signaling. Several effects of GLP-1 were studied in INS-1E rat beta cells transfected either with an inhibitor of insulin receptor function, or with insulin receptor small interfering RNA, as well as in control cells. [PLoS One] Full Article PANCREATIC CANCERResearchers showed that heat shock factor 1 (HSF1) is abnormally activated in pancreatic cancer. The knockdown of (HSF1) impaired the invasion and migration and epithelial-mesenchymal transition of pancreatic cancer cells in vitro; however, the up-regulation of HSF1 showed the opposite effects. [Mol Oncol] Full Article Scientists performed RNA-sequencing analysis of laser capture microdissected pancreatic intraepithelial neoplasias (PanINs) and normal pancreatic duct cells to identify differentially expressed genes between PanINs and normal pancreatic duct, and between low-grade and high-grade PanINs. [Oncotarget] Full Article The ethanol extract of propolis from the Vietnamese stingless bee T. minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium. [J Nat Prod] Abstract | Graphical Abstract Interaction Between NFATc2 and the Transcription Factor Sp1 in Pancreatic Carcinoma Cells PaTu 8988t Investigators identified and characterized possible interaction partners of the transcription factor NFATc2 in pancreatic carcinoma cells PaTu 8988t. [BMC Mol Biol] Full Article | |
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REVIEWSAutoreactive T Cells in Type 1 Diabetes Researchers provide an overview of recent progress in the knowledge of autoreactive T cells that has emerged from experimental and clinical research as well as pathology investigations. [J Clin Invest] Abstract The Na+/Ca2+ Exchanger and the Plasma Membrane Ca2+-ATPase in β-Cell Function and Diabetes The authors provide two unique models for the prevention and treatment of β-cell dysfunction in diabetes and following islet transplantation. [Neurosci Lett] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSDiabetes Center Established at JABSOM with $11.2 Million Federal Grant The University of Hawaiʻi at Mānoa has been awarded a major federal grant to establish a Center for Biomedical Research Excellence on Diabetes. The $11.2 federal grant will intensify Hawaiʻi-based research into a disease that currently affects 155,000 adults and children—1 in 9 individuals in Hawaiʻi. [University of Hawaiʻi] Press Release The Cancer Research Institute and Israel Cancer Research Fund announced the establishment of The Immunotherapy Promise™ fund, a groundbreaking, collaborative campaign bringing together the leading funder of immunotherapy research internationally with North America’s largest nonprofit dedicated to supporting Israeli cancer research. [Cancer Research Institute] Press Release | |
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POLICY NEWSCRISPR Patent Battle in Europe Takes a ‘Wild’ Twist with Surprising Player MilliporeSigma, a subsidiary of pharmaceutical giant Merck KGaA of Darmstadt, Germany, has become a new major player in the complicated European patent battles over CRISPR, the revolutionary genome-editing tool. [ScienceInsider] Editorial FDA Cracks Down on Pioneering Doctor Who Created a Three-Parent Baby The New York-based doctor who helped a couple have a child using DNA from three people has been told by the U.S. FDA that he can’t go ahead with clinical trials meant to test the technique. [MIT Technology Review] Editorial Senate Passes FDA User Fee and Right-to-Try Bills The Senate has voted in quick succession to pass bills reauthorizing the FDA to collect fees from the industry and expanding access to unapproved medicines. President Trump is set to sign the user fee bill into law, while the right-to-try legislation will go to the House. [FierceBiotech] Editorial
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EVENTSNEW AACR-NCI-EORTC International Conference on Molecular Targets & Cancer Therapeutics Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant Investigator – Cancer Genetics, Epigenetics and Biomarkers (Baylor Research Institute) NEW Postdoctoral Fellow – Cancer Genetics, Epigenetics and Biomarkers (Baylor Research Institute) NEW Research Assistant – Cancer Genetics, Epigenetics and Biomarkers (Baylor Research Institute) Postdoctoral Position – Immunology (Harvard Medical School) Faculty Positions – Diabetes, Obesity, and Metabolism (University of Pittsburgh) Postdoctoral Research Scientist – Mechanisms of Obesity and Diabetes (NYU Langone Medical Center) Postdoctoral Researcher – Obesity and Diabetes (University of Iowa) Assistant Professor – Metabolic Disorders (Umeå University) Group Leader – Cancer Research (University of Lille) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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