Pancreatic Cell News 8.44 November 7, 2017 | |
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TOP STORYArtemether Does Not Turn α Cells into β Cells Scientists found no evidence that artemether promotes transdifferentiation of primary α cells into β cells. Artemether reduced Ins2 expression in primary β cells >100-fold, suppressed glucose uptake, and abrogated β cell calcium responses and insulin secretion in response to glucose. [Cell Metab] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISLoss of mTORC1 Signaling Alters Pancreatic α Cell Mass and Impairs Glucagon Secretion Researchers identified mTOR complex 1 (mTORC1) as a major regulator of α cell mass and glucagon secretion. Using mice with tissue-specific deletion of the mTORC1 regulator Raptor in α cells, they showed that mTORC1 signaling is dispensable for α cell development, but essential for α cell maturation during the transition from a milk-based diet to a chow-based diet after weaning. [J Clin Invest] Abstract Investigators present a noble design to control the oxygen distribution in concave microwell arrays for the formation of highly functional pancreatic islet spheroids by engineering the bottom of the microwells. [Acta Biomater] Abstract The authors developed a human microfluidic two-organ-chip model to study pancreatic islet–liver cross-talk based on insulin and glucose regulation. [Sci Rep] Full Article Investigators tested how unsaturated oleic acid affects the effect of saturated stearic acid on the p38 mitogen-activated protein (MAP) kinase and extracellular signal-regulated kinase pathways, as well as the endoplasmic reticulum (ER) stress signaling pathways during apoptosis induction in the human pancreatic β-cells NES2Y. [Int J Mol Sci] Full Article Researchers provided direct evidence for the essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion and also showed the usefulness of the CRISPR/Cas9 system for studying β-cells by simultaneous disruption of multiple genes. [PLoS One] Abstract PANCREATIC CANCERPancreatic acinar cell carcinoma is an aggressive exocrine tumor with largely unknown biology. To identify potential targets for personalized treatment, scientists performed integrative genome-wide and epigenome-wide analyses. [Nat Commun] Full Article By implanting pancreatic cancer cell strains Panc-1, Bxpc-3 and SW1990 in nude mice in situ, researchers successfully established the orthotopic xenograft models of pancreatic ductal adenocarcinoma with different differentiations. [BMC Cancer] Full Article Scientists performed an in depth shotgun proteomic approach using the label-free proteomic SWATH-MS analysis to investigate novel insights of the mechanism of action of the histone deacetylase inhibitor trichostatin A in pancreatic ductal adenocarcinoma cells. [J Cell Biochem] Abstract | |
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REVIEWSThe authors review biological properties of pancreas/duodenum homeobox protein 1 (PDX1), neurogenin-3, and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA), and their applications and limitations for beta cell regenerative approaches. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSO304 significantly reduced fasting plasma glucose in type 2 diabetics. [Betagenon AB] Press Release NanOlogy LLC announced the first patient has been enrolled in a clinical trial of NanoPac® sterile suspension for treatment of mucinous cystic neoplasms of the pancreas. [NanOlogy LLC] Press Release | |
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POLICY NEWSCourt Demands that Search Engines and Internet Service Providers Block Sci-Hub The American Chemical Society (ACS) has won a lawsuit against Sci-Hub, a website providing illicit free access to millions of paywalled scientific papers. ACS had alleged copyright infringement, trademark counterfeiting and trademark infringement; a district court in Virginia ruled that Sci-Hub should pay the ACS $4.8 million in damages after Sci-Hub representatives failed to attend court. [ScienceInsider] Editorial When Representative Lamar Smith announced that he would not run for re-election in 2018, after 32 years in Congress, many scientists reacted with glee. [ScienceInsider] Editorial
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EVENTSNEW 14th Annual Stem Cell Symposium: Technology Innovation for Stem Cell Research and Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Pathogenesis of Type 1 Diabetes (Helmholtz Zentrum München) Postdoctoral Position – Pancreatic Cancer (Translational Genomics Research Institute) Assistant Professor – Cancer Biology (Perelman School of Medicine) PhD Studentships – Cancer Research (University of Cambridge) Research Fellow – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Pancreatic Cancer (University of California, San Francisco) Faculty Positions – Cancer Research (Huntsman Cancer Institute) Researcher – Cancer Biology (University of Cincinnati) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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