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Pulmonary Cell News| Pancreatic Cell News 8.45 November 14, 2017 | |
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TOP STORYScientists used a newly designed tumor-targeted oncolytic adenovirus to deliver non-secreting interleukin-12 to tumor cells and examine the therapeutic and toxic effects in Syrian hamster models of pancreatic cancer. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe authors identified novel signaling pathways involved in the initial release of insulin from pancreatic islet β-cells after glucose stimulation using quantitative strategies for the assessment of phosphorylated proteins and sialylated N-linked glycoproteins. [Mol Cell Proteomics] Abstract | Full Article A Nanobody-Based Tracer Targeting DPP6 for Non-Invasive Imaging of Human Pancreatic Endocrine Cells Investigators coupled RNA sequencing of human pancreatic islets to a systems biology approach to identify new biomarkers of the endocrine pancreas. [Sci Rep] Full Article Acinar Injury and Early Cytokine Response in Human Acute Biliary Pancreatitis Researchers evaluated the early interactions of bile acid induced human pancreatic acinar injury and the resulting cytokine response. They exposed freshly procured resected human pancreata to taurolithocolic acid and evaluated for acinar injury, cytokine release and interaction with peripheral blood mononuclear cells. [Sci Rep] Full Article Metabolic Regulation of GLP-1 and PC1/3 in Pancreatic α-Cell Line Upon 16.7G incubation, glucagon like-peptide–1 (GLP-1) secretion was significantly increased in parallel with a significant increment in proconvertase (PC) 1/3 expression, a slight increase in cell viability and reactive oxygen species generation and by a decrement in PC2 expression with no change in cell apoptosis. [PLoS One] Full Article PANCREATIC CANCERScientists showed that aberrant expression of BAG3 significantly contributes to the reprogramming of glucose metabolism in pancreatic ductal adenocarcinoma cells. [J Cell Biol] Abstract NORAD expression was measured in 33 paired cancerous and noncancerous tissue samples by real-time PCR. The effects of NORAD on pancreatic cancer cells were studied by overexpression and knockdown in vitro. [Mol Cancer] Full Article A New Panel of Pancreatic Cancer Biomarkers Discovered Using a Mass Spectrometry-Based Pipeline Scientists developed a coherent, high-throughput and non-discriminatory pipeline for the novel clinical biomarker discovery of pancreatic carcinoma. [Br J Cancer] Abstract Investigators found that ZEB1 is the only epithelial-to-mesenchymal transition-related transcription factor that clearly segregates mesenchymal and epithelial pancreatic ductal adenocarcinoma cell lines. [Cell Death Dis] Full Article Researchers revealed the functional effects of MEG3 on pancreatic neuroendocrine tumors. The expression of MEG3, miR-183, and BRI3 in BON1 cells were altered by transfection with their specific vectors/shRNA, or mimic/inhibitor. [Cell Physiol Biochem] Full Article The authors demonstrated that ETV4 is overexpressed in pancreatic cancer (PC) tissues as compared to the normal pancreas, and is associated with enhanced growth and rapid cell cycle progression of PC cells. [Mol Cancer Res] Abstract | |
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REVIEWSRegenerating β Cells of the Pancreas – Potential Developments in Diabetes Treatment Current β cell regeneration strategies can be classified into two main categories: in vitro β cell regeneration using pluripotent stem cells and in vivo reprogramming of non-β cells into β cells. The rationale and progress of each β cell regeneration strategy is reviewed. [Expert Opin Biol Ther] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSOncoQuest Inc. announced that it will be presenting pre-clinical data from its immunoglobulin E (IgE) based immunotherapy platform technology, titled “Tumor Protective Effect of Anti-MUC1 IgE in Pancreatic Cancer”. [Press release from Quest PharmaTech Inc. discussing research to be presented at the 32nd Annual Society for Immunotherapy of Cancer (SITC) meeting, National Harbor] Press Release | |
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INDUSTRY NEWSZydus Announces Regulatory Approval of Lipaglyn™ (Saroglitazar Magnesium) in Mexico Zydus announced that the Mexico regulatory authority COFEPRIS, has granted marketing approval to commercialize Lipaglyn™ in Mexico for the treatment of dyslipidemia in patients with diabetes mellitus type 2 and hypertriglyceridemia in patients with diabetes mellitus type 2 not controlled by statins. [Zydus Cadila] Press Release ImmunoMolecular Therapeutics (IM Therapeutics) made its debut as a spinout from the Barbara Davis Center for Diabetes at the University of Colorado. IM Therapeutics was created to advance new therapeutic strategies for Type 1 Diabetes that aim to directly inactivate pathogenic immune cells responsible for damaging the insulin-producing beta cells in the pancreas. [ImmunoMolecular Therapeutics] Press Release Bristol-Myers Squibb Company and Five Prime Therapeutics, Inc. announced preliminary results from a dose escalation and expansion study evaluating the safety, pharmacokinetics and pharmacodynamics of cabiralizumab in combination with Opdivo in patients with advanced solid tumors. [Bristol-Myers Squibb Company] Press Release | |
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POLICY NEWSGraduate Students Face Alarming Tax Hike The last thing that graduate students need is a tax hike. But that is what many would face under a clause in the federal-tax-reform bill passed by the US House of Representatives. It will need to be reconciled with the Senate’s tax-reform bill (which retains many existing student tax benefits), and signed by the president. [Nature News] Editorial UK Government Appoints Next Chief Scientific Adviser Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial
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EVENTSNEW 13th Annual Wisconsin Stem Cell Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Pancreatic Physiology (Inserm) NEW Postdoctoral Position – Diabetes (National Institute of Diabetes & Digestive & Kidney Diseases) Postdoctoral Position – Pathogenesis of Type 1 Diabetes (Helmholtz Zentrum München) Postdoctoral Position – Pancreatic Cancer (Translational Genomics Research Institute) Assistant Professor – Cancer Biology (Perelman School of Medicine) PhD Studentships – Cancer Research (University of Cambridge) Research Fellow – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Pancreatic Cancer (University of California, San Francisco) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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