Pancreatic Cell News Volume 8.46 | Nov 21 2017

TOP STORY

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Investigators showed that accumulation of the autophagy substrate p62/SQSTM1 in stressed Kras^G12D acinar cells is associated with pancreatic ductal adenocarcinoma development and maintenance of malignancy in human cells and mice. [Cancer Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Selenoprotein P-Neutralizing Antibodies Improve Insulin Secretion and Glucose Sensitivity in Type 2 Diabetes Mouse Models

The authors developed an anti-human selenoprotein P (SeP) monoclonal antibody AE2 with neutralizing activity against SeP. Administration of AE2 to mice significantly improved glucose intolerance and insulin resistance that was induced by human SeP administration. [Nat Commun] Full Article

Resveratrol Ameliorates the Severity of Fibrogenesis in Mice with Experimental Chronic Pancreatitis

Scientists demonstrated that the oral administration of resveratrol effectively attenuated pancreatic stellate cell activation, extracellular matrix deposition, fibrogenesis and acinar atrophy in the pancreatitic parenchyma of cerulein-induced mice as the damage index score was improved by 45.5%. [Mol Nutr Food Res] Abstract

Nkx6.1 Decline Accompanies Mitochondrial DNA Reduction but Subtle Nucleoid Size Decrease in Pancreatic Islet β-Cells of Diabetic Goto Kakizaki Rats

Researchers confirmed mitochondrial (mt) DNA copy number decrease down to <30% in pancreatic islets of one-year-old Goto Kakizaki rats. Studying relations to mt nucleoids sizes, they employed 3D superresolution fluorescent photoactivable localization microscopy with lentivirally transduced Eos conjugate of mt single-stranded-DNA-binding protein or transcription factor TFAM; or by 3D immunocytochemistry. [Sci Rep] Full Article

Sirolimus Induces Depletion of Intracellular Calcium Stores and Mitochondrial Dysfunction in Pancreatic Beta Cells

Scientists showed that sirolimus impairs glucose-stimulated insulin secretion both in human and murine pancreatic islets and in clonal β cells in a dose- and time-dependent manner. [Sci Rep] Full Article

PANCREATIC CANCER

MicroRNA Expression Profiling of Pancreatic Cancer Cell Line L3.6p1 following B7-H4 Knockdown

A microarray technique was used to screen B7-H4-related differentially expressed miRNAs in a pancreatic cancer cell line associated with pancreatic cancer. [Cell Physiol Biochem] Full Article

YTH Domain Family 2 Orchestrates Epithelial-Mesenchymal Transition/Proliferation Dichotomy in Pancreatic Cancer Cells

Scientists found that YTH domain family 2 (YTHDF2) expression is up-regulated in pancreatic cancer tissues compared with normal tissues at both mRNA and protein levels, and is higher in clinical patients with later stages of pancreatic cancer, indicating that YTHDF2 possesses potential clinical significance for diagnosis and prognosis of pancreatic cancers. [Cell Cycle] Abstract

Effect of Plasma-Activated Lactated Ringer’s Solution on Pancreatic Cancer Cells In Vitro and In Vivo

Investigators produced plasma-activated lactated Ringer’s solution (PAL) and evaluated its antitumor effect and mechanism. They evaluated the effect of the intraperitoneal administration of PAL using a peritoneal dissemination mouse tumor model. [Ann Surg Oncol] Abstract

Relationship between LAT1 Expression and Resistance to Chemotherapy in Pancreatic Ductal Adenocarcinoma

In vitro analysis of chemotherapy resistance and L-type amino acid transporter 1 (LAT1) function using pancreatic ductal adenocarcinoma cell lines was performed. [Cancer Chemother Pharmacol] Abstract

An Overview of Polyamine Metabolism in Pancreatic Ductal Adenocarcinoma

Scientists describe what is currently known about polyamine metabolism in pancreatic ductal adenocarcinoma and identify new targets and opportunities to treat this disease. [Int J Cancer] Abstract

Experimental Models of Pancreatic Cancer Desmoplasia

The authors review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer. [Lab Invest] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

CELLINK Enters a Collaborative Research Program with Takara Bio

CELLINK and Takara Bio Europe AB will collaborate to evaluate bioprinting of CELLINK’s Bioink with Takara’s cells for insulin secretion by induced pluripotent stem cell derived beta cells. [CELLINK AB] Press Release

Sabga Foundation Pledges $1 Million towards TGen Pancreatic Cancer Research

World Pancreatic Cancer Day is the kickoff of a $1 million drive by the recently formed John E. Sabga Foundation to fund an innovative clinical trial led by the Translational Genomics Research Institute (TGen) to test revolutionary new treatments for pancreatic cancer. [Translational Genomics Research Institute] Press Release

Director of HHS Scientific Fraud Office Is out after Stormy 2-Year Tenure

The controversial director of the office that polices research fraud in U.S.-funded biomedical labs is temporarily moving to another agency. Kathy Partin has been removed after nearly two years as director of the U.S. Office of Research Integrity in Rockville, Maryland, according to Retraction Watch. [ScienceInsider] Editorial

European Medicines Agency Will Move to Amsterdam

The European Medicines Agency, charged with evaluating human and animal medicinal products for the European Union, will relocate to Amsterdam after it was selected in a draw of lots between it and Milan. [ScienceInsider] Editorial

Hungary Rewards Highly Cited Scientists with Bonus Grants

Some top researchers prosper in Hungary as country tries to improve its international standing in science. [Nature News] Editorial

Sudden Shift at a Public Health Journal Leaves Scientists Feeling Censored

For much of its 22-year existence, few outside the corner of science devoted to toxic chemicals paid much attention to the International Journal of Occupational and Environmental Health. But now, a feud has erupted over the small academic publication, as its editorial board — the scientists who advise the journal’s direction and handle article submissions — has accused the journal’s new owner of suppressing a paper and promoting “corporate interests over independent science in the public interest.” [Pro Publica Inc.] Editorial

NEW SYStem – Symposium for the Next Generation of Stem Cell Researchers
February 22-24, 2018
Vienna, Austria

Visit our events page to see a complete list of events in the community.

NEW Research Technologist – Pancreatic Cell Biology (STEMCELL Technologies Inc.)

NEW Postdoctoral Positions – Pancreatic Cancer (MD Anderson Cancer Center)

Postdoctoral Position – Pathogenesis of Type 1 Diabetes (Helmholtz Zentrum München)

Postdoctoral Position – Pancreatic Cancer (Translational Genomics Research Institute)

Assistant Professor – Cancer Biology (Perelman School of Medicine)

Director – David M. Rubenstein Center for Pancreatic Cancer Research (Memorial Sloan Kettering Cancer Center)

PhD Studentships – Cancer Research (University of Cambridge)

Research Fellow – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Pancreatic Cancer (University of California, San Francisco)

Faculty Positions – Cancer Research (Huntsman Cancer Institute)

Researcher – Cancer Biology (University of Cincinnati)

Scientist – Diabetes and Obesity (Helmholtz Zentrum München)

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