Pancreatic Cell News 8.47 November 28, 2017 | |
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TOP STORYResearchers showed that lipid-polymer hybrid nanoparticle–catalyzed hairpin DNA circuit biochip with signal amplification capability could selectively and sensitively identify low expression glypican-1 mRNA in serum extracellular vesicles, distinguishing patients with early- and late-stage pancreatic cancer from healthy donors and patients with benign pancreatic disease. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISScientists showed that autophagy was induced in beta cells by either a high-fat diet or a combined high-fat and high-glucose diet, but not by high-glucose alone. [Sci Rep] Full Article Investigators analyzed the interplay of PDX-1, USF1 and CK2 in the regulation of PDX-1 gene transcription. They found that the PDX-1 promoter is dose-dependently transactivated by PDX-1 and transrepressed by USF1. [Sci Rep] Full Article ERK5 Plays an Essential Role in Gestational Beta-Cell Proliferation Researchers studied the activation of extracellular-signal-regulated kinase 5 (ERK5) in pregnant mice, a well-known mouse model of increased beta-cell proliferation. Extracellular-signal-regulated kinase 5 phosphorylation, which represents ERK5 activation, was significantly upregulated in islets from pregnant mice. [Cell Prolif] Abstract PANCREATIC CANCERThe authors analyzed ductal and neuroendocrine markers in pancreatic ductal adenocarcinoma, revealing heterogeneous expression of the neuroendocrine marker synaptophysin within ductal lesions. [Nat Commun] Full Article Researchers uncovered the complex and diverse interplay between pancreatic ductal adenocarcinoma (PDAC) tumors and the stroma and demonstrated the pivotal role of xenografts for drug discovery and relevance to PDAC. [Cell Rep] Full Article | Graphical Abstract The authors found that Yin Yang-1 (YY1) overexpression or knockdown can inhibit or promote the proliferation and migration of pancreatic cancer cells. [Int J Cancer] Abstract Scientists generated pancreatic cancer cell lines expressing both cadherin-1 and cadherin-3 or only one of these cadherins. Functional implications of such genetic alterations were analyzed both in vitro and in vivo. [Br J Cancer] Abstract MiRNAs Are Unlikely to Be Involved in Retinoid Receptor Gene Regulation in Pancreatic Cancer Cells Researchers investigated whether selected dysregulated miRNAs in pancreatic duct adenocarcinoma (PDAC) are responsible for the decreased level of retinoid receptors. Bioinformatics, real-time PCR, western blot analysis as well as molecular manipulation with miRNA in cells of PDAC were carried out. [Cell Physiol Biochem] Full Article | |
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REVIEWSPERK Leads a Hub Dictating Pancreatic β Cell Homeostasis Multiple studies involving cell cultures, animal models, and human subjects have established the importance of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) in the adaptive functional capacity of pancreatic β cells during embryonic development and into adulthood.The authors highlight major findings identifying PERK as a crucial player in β cell physiology and in diabetes. [Biol Cell] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSRafael Pharmaceuticals, Inc. announced the initiation of a Phase I clinical trial of CPI-613 in combination with chemotherapeutic agents, gemcitabine and nab-paclitaxel, for patients with locally advanced or metastatic pancreatic cancer. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release PharmaCyte Biotech, Inc. reported that Eurofins Lancaster Laboratories successfully completed its independent growth evaluation of the cells that PharmaCyte will use in its Cell-in-a-Box®-based pancreatic cancer therapy. [PharmaCyte Biotech, Inc. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSZimbabwe’s Researchers Hope Political Change Will Revitalize Science Academics are optimistic that the end of Robert Mugabe’s authoritarian rule could boost research and international collaboration. [Nature News] Editorial United Kingdom Relies on Science to Revive Flagging Economy The United Kingdom has laid out how it will pour money into research to boost its economy — including cash for artificial intelligence and other high-tech industries — as the country prepares to leave the European Union in 2019. [Nature News] Editorial Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage Eager to speed development of revolutionary treatments, the Food and Drug Administration recently announced that it would expedite approval of experimental gene therapies. But the regulatory process may not be the biggest obstacle. [The New York Times] Editorial Nobel Laureates Demand Release of Iranian Scholar Facing Death Sentence Some 75 Nobel prize winners have called on the Iranian government to release Ahmadreza Djalali, a researcher in disaster medicine who was sentenced to death last month. The letter is the latest and most powerful protest against the ruling by the scientific community so far. [Nature News] Editorial
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EVENTSNEW Pancreas 2018, Innovations in the Care of Pancreatic Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Studentship – Pancreas Development and Stem Cells (Helmholtz Zentrum München) Research Technologist – Pancreatic Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Positions – Pancreatic Cancer (MD Anderson Cancer Center) Postdoctoral Position – Pathogenesis of Type 1 Diabetes (Helmholtz Zentrum München) Postdoctoral Fellowship Positions – Pancreatic Cancer (Translational Genomics Research Institute) Assistant Professor – Cancer Biology (Perelman School of Medicine) Research Fellow – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center) Postdoctoral Scholar – Pancreatic Cancer (University of California, San Francisco) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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