Pancreatic Cell News 9.01 January 9, 2018 | |
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TOP STORYThe authors infused adeno-associated virus carrying Pdx1 and MafA expression cassettes through the pancreatic duct to reprogram alpha cells into functional beta cells and normalized blood glucose in both beta cell-toxin-induced diabetic mice and in autoimmune non-obese diabetic mice. [Cell Stem Cell] Full Article | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISEndocytosis of KATP Channels Drives Glucose-Stimulated Excitation of Pancreatic β Cells Scientists showed that control of KATP channel surface density plays a greater role than ATP-dependent gating in regulating β cell excitability. [Cell Rep] Full Article | Graphical Abstract Inducible beta cell-specific Ubc9 knockout and transgenic mice were employed to address the impact of SUMOylation on beta cell viability and functionality. [Diabetologia] Abstract IFN-α Induces a Preferential Long-Lasting Expression of MHC Class I in Human Pancreatic Beta Cells IFN-α-induced MHC class I overexpression, endoplasmic reticulum stress and inflammation were evaluated by flow cytometry, immunofluorescence and real-time PCR in human EndoC-βH1 cells or human islets exposed to IFN-α with or without the presence of Janus kinase inhibitors. [Diabetologia] Abstract PANCREATIC CANCERInvestigators demonstrated that transcriptional co-activator with PDZ-binding motif (TAZ), which is associated with drug resistance of pancreatic cancer, is a new direct downstream target of miR-455-3p. [Mol Ther Nucleic Acids] Full Article Targeted Delivery of Auristatin-Modified Toxins to Pancreatic Cancer Using Aptamers Scientists assayed the toxicity of monomethyl auristatin E and monomethyl auristatin F conjugated to an anti-transferrin receptor aptamer, Waz, and an anti-epidermal growth factor receptor aptamer, E07, on the pancreatic cancer cell lines Panc-1, MIA PaCa-2, and BxPC3. [Mol Ther Nucleic Acids] Full Article The authors showed that carnitine palmitoyltransferase 1C, an enzyme that catalyzes carnitinylation of fatty acids for transport into mitochondria for β-oxidation, plays a major role in the regulation of cancer cell senescence through mitochondria-associated metabolic reprogramming. [Cell Death Differ] Abstract MTOR Inhibitor-Based Combination Therapies for Pancreatic Cancer Genetic deletion of the Mtor gene in the pancreas resulted in exocrine and endocrine insufficiency. In established murine pancreatic ductal adenocarcinoma cells, MTOR was linked to metabolic pathways and maintained the glucose uptake and growth. [Br J Cancer] Abstract Chk1 Inhibitor SCH 900776 Enhances the Antitumor Activity of MLN4924 on Pancreatic Cancer Researchers found that MLN4924 inhibited the proliferation and clonogenicity of pancreatic cancer cells, caused DNA damage, particularly double-strand breaks, and leaded to Chk1 activation and cell-cycle arrest. [Cell Cycle] Abstract | |
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REVIEWSReshaping the Tumor Stroma for Treatment of Pancreatic Cancer The authors review recently developed approaches for re-shaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. They also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism and discuss the implications for the development of stromal compartment-specific therapies. [Gastroenterology] Abstract Researchers focus on the regulatory effects of extracellular vesicles on pancreatic cancer progression, metastasis, cancer-related immunity and chemoresistance, particularly their potential roles as biomarkers and therapeutic targets. [Mol Cancer] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSGeNeuro Completes Patient Enrollment in Phase IIa Study of GNbAC1 in Type 1 Diabetes GeNeuro announced that patient enrollment in its Australian Phase IIa study of GNbAC1 in type 1 diabetes has been completed on schedule. [GeNeuro] Press Release ViaCyte, Inc. announced that the first patients have been implanted in Cohort 2 with a potentially efficacious dose of the company’s PEC-Direct islet cell replacement therapy. [ViaCyte, Inc.] Press Release | |
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POLICY NEWSKoch-Backed Groups Urge Congress to Pass Right-to-Try Legislation Several deep-pocketed political advocacy groups founded by Charles and David Koch are ramping up their advocacy before Congress on a niche issue: access to experimental drugs. [STAT News] Editorial Germany vs Elsevier: Universities Win Temporary Journal Access after Refusing to Pay Fees The Dutch publishing giant Elsevier has granted uninterrupted access to its paywalled journals for researchers at around 200 German universities and research institutes that had refused to renew their individual subscriptions at the end of 2017. [Nature News] Editorial
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EVENTSNEW Applications of Organoid Technology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Tenure-Track Group Leader Position – Pancreatic Cancer Biology (University of Copenhagen) Postdoctoral Research Fellow – Pancreatic Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Research Fellow – Structure-Guided Drug Discovery (Univertsity of Hertfordshire) Postdoctoral Fellowship – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center) PhD Studentship – Pancreatic Cancer (CRUK Manchester Institute) Postdoctoral Fellowship (Memorial Sloan Kettering Cancer Center) PhD Studentship – Pancreas Development and Stem Cells (Helmholtz Zentrum München) Postdoctoral Positions – Pancreatic Cancer (MD Anderson Cancer Center) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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