Pancreatic Cell News 9.15 April 17, 2018 | |
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TOP STORYLRH-1 Agonism Favors an Immune-Islet Dialogue Which Protects against Diabetes Mellitus Scientists showed that BL001, a small liver receptor homologue-1 (LRH-1) agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of type 1 diabetes mellitus, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISInvestigators showed that β cells of newborns secrete more insulin than adults in response to similar intracellular Ca2+ concentrations, suggesting differences in the Ca2+ sensitivity of insulin secretion. [Dev Cell] Full Article | Graphical Abstract Researchers investigated T cell recognition of peptides that correspond to modified beta cell antigens in subjects with type 1 diabetes. [Diabetes] Abstract Increased Chromogranin A-Positive Hormone Negative Cells in Chronic Pancreatitis Scientists investigated the frequency and distribution of chromatin A-positive hormone negative cells and the expression of the chemokine CXCL10 and its receptor CXCR3 in pancreas of ND subjects with chronic pancreatitis. [J Clin Endrocrinol Metab] Abstract Investigators reported the microRNA expression profiles analysis of in vitro dedifferentiated islet cells in comparison to mature human native pancreatic islets. They identified 13 microRNAs upregulated and 110 downregulated in islet cells upon in vitro dedifferentiation. [Int J Mol Sci] Full Article | Graphical Abstract PANCREATIC CANCERResearchers investigated the detailed roles and mechanisms of tumor-generated exosomes in progression and metastasis of pancreatic ductal adenocarcinoma in vitro and in vivo. [Oncogene] Abstract IL23 and TGF-ß Diminish Macrophage Associated Metastasis in Pancreatic Carcinoma In order to understand the role of IL23, an interleukin associated with macrophage polarization, the authors investigated IL23 in the context of TGF-ß expression in pancreatic ductal adenocarcinoma. [Sci Rep] Full Article MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells Scientists defined that miRNAs, miR-17-5p, miR-132-3p/-212-3p, and miR-337-3p are significantly up-regulated in the pancreatic ductal adenocarcinomas compared to the normal and benign tissues. [Int J Mol Sci] Full Article | Graphical Abstract Researchers reported the results of a high-throughput synthetic lethal screen for small molecules that selectively inhibit the growth of KRAS mutant cell lines in soft agar. [Cell Chem Biol] Abstract | Graphical Abstract | |
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REVIEWSNatural Killer Cells and Their Therapeutic Role in Pancreatic Cancer: A Systematic Review The authors summarise the pathophysiological adaptions of natural killer (NK) cells in pancreatic cancer and highlight possible (future) therapeutic NK cell-related targets. [Pharmacol Ther] Abstract Investigators describe the clinicopathological significance of mesothelin expression in pancreatic cancer initiation and progression, summarize available studies evaluating mesothelin as a potential diagnostic and prognostic biomarker in this disease, and discuss current evidence and future perspectives of preclinical and clinical studies testing mesothelin as a molecular target for pancreatic cancer treatment. [Target Oncol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSViaCyte, Inc., announced that President and CEO, Paul Laikind, Ph.D., will present. ViaCyte is developing novel stem cell-derived islet replacement therapies for insulin-requiring diabetes. [Press release from ViaCyte discussing research to be presented at the 6th annual Alliance for Regenerative Medicine’s Cell & Gene Therapy Investor Day, New York City] Press Release | |
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INDUSTRY NEWSThe Lustgarten Foundation and Stand Up To Cancer announced that they are entering into a formal strategic partnership to drive research to improve outcomes for pancreatic cancer patients. The $25 million Pancreatic Cancer Collective, funded by the Lustgarten Foundation and Stand Up To Cancer, will accelerate research for pancreatic cancer patients who desperately need better treatments. [The Entertainment Industry Foundation and Lustgarten Foundation] Press Release University of Nevada, Reno School of Medicine Associate Professor Seungil Ro, Ph.D., department of physiology and cell biology, has made an important discovery-finding a molecule that can be used to inhibit and treat type 2 diabetes. This new discovery helped obtain $2 million in funding for project development over the course of the next three years. [University of Nevada, Reno School of Medicine] Press Release ViaCyte, Inc., announced that it has been awarded a Small Business Innovative Research (SBIR) Phase II Award from the National Institute of Diabetes and Digestive and Kidney Diseases to support the further development of functional human beta cells in vitro. [Viacyte, Inc] Press Release ADOCIA announced the initiation of a Phase I study of BioChaperone® Pramlintide Insulin, its ready-to-use co-formulation of pramlintide and human insulin. [Adocia] Press Release | |
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POLICY NEWSA Final Dash across the United States: Updates from the 2018 March for Science The March for Science celebrated its anniversary. And although the turnout around the world was significantly smaller than last year, supporters haven’t lost any of their energy. [ScienceInsider] Editorial Spain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature News] Editorial Panel Calls for a Postdoc Tax and Other Measures to Help Biomedical Scientists Find Jobs The U.S. Congress, federal funding agencies, universities, and other research institutions must take significant steps, such as a postdoc “tax” and a hard cap on how long postdocs can be funded by a lab head, to better usher young biomedical scientists into viable careers, a committee from the National Academies of Sciences, Engineering, and Medicine concluded in a report. [ScienceInsider] Editorial
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EVENTSNEW 6th Annual German Stem Cell Network (GSCN) Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Genetic Epidemiology of Metabolic Disease (University of Cambridge) NEW Director and Biometrics Team Leader – Diabetes and Metabolic Disease (AstraZeneca) NEW Postdoctoral Fellow – Pancreatic Cancer Research (Univeristy of South Wales) Research Fellow/Associate – Diabetes Research (Rutgers University) Postdoctoral Position – Pancreatic Cancer (Fox Chase Cancer Center) Postdoctoral Scholar – Cancer (University of California, San Francisco) Postdoctoral Position – Protein Biochemistry (Vlaams Instituut voor Biotechnologie) Postdoctoal Fellow – Pancreatic Cell (Inserm) Postdoctoral Fellow – Diabetes and Pancreatic Islet Biology (Vanderbilt University) Postdoctoral Scientist – Epigenetic Mechanisms (Geneva University) Postdoctoral Fellow – Epigenetic Regulation of Pancreatic Beta-Cell Mass (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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