Pancreatic Cell News 9.17 May 1, 2018 | |
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TOP STORYPiezo1 Is a Mechanically Activated Ion Channel and Mediates Pressure Induced Pancreatitis The authors demonstrated that pancreatic acinar cells express the mechanoreceptor piezo1 and application of pressure within the gland produces pancreatitis. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISPancreatic β Cells Overexpressing hIAPP Impaired Mitophagy and Unbalanced Mitochondrial Dynamics Researchers investigated comparatively the impact of human islet amyloid polypeptide (hIAPP) on key pathways involved in pancreatic beta survival. [Cell Death Dis] Full Article Scientists showed that islet surface density can be substantially increased safely by increasing gas chamber pO2 to a supraphysiological level that maintains all islets viable and functional. [Sci Rep] Full Article | Press Release Prion Protein Modulates Glucose Homeostasis by Altering Intracellular Iron The prion protein (PrPC), a mainly neuronal protein, is known to modulate glucose homeostasis in mouse models. Investigators reported expression of PrPC on mouse pancreatic β-cells, where it promoted uptake of iron through divalent-metal-transporters. [Sci Rep] Full Article PANCREATIC CANCERPre-Neoplastic Pancreas Cells Enter a Partially Mesenchymal State following Transient TGF-β Exposure Using 3D cultures of KrasG12D-expressing mouse pancreatic epithelial cells, scientists demonstrated that while exposure to exogenous TGF-β induced growth arrest of the KrasG12D cells, its subsequent removal allowed the cells to enter a hyper-proliferative, partially mesenchymal, and progenitor-like state. [Oncogene] Abstract The authors highlighted the function of metastasis-associated protein 2 (MTA2) in pancreatic carcinoma through its role as a deacetylator of hypoxia‐inducible factor-1α (HIF-1α) and a co-transcriptional factor for E-cadherin expression. [J Pathol] Abstract To evaluate the efficiency of pancreatic ductal adenocarcinoma epigenetic reprogramming, investigators assessed tumor growth and drug response in PANC-1 cells after exposure to non-cytotoxic doses of the demethylating agent 5-azacytidine. [Cell Death Dis] Full Article Scientists found that gastrin induced phosphorylation of paxillin at tyrosine 31/118 and RhoA activation as well as promoted the metastasis of PANC-1 cancer cells. [Exp Mol Med] Full Article dCK Negatively Regulates the NRF2/ARE Axis and ROS Production in Pancreatic Cancer The contribution of deoxycytidine kinase (dCK) to the transcription factor NF‐E2 p45‐related factor 2 (NRF2) signaling axis has seldom been discussed and needs investigation. By overexpressing dCK in pancreatic cancer cells, researchers assessed the impact of dCK on NRF2 transcriptional activity. [Cell Prolif] Full Article Investigators described the generation and characterization of a novel oncolytic chimeric orthopoxvirus for the treatment of pancreatic cancer. [J Transl Med] Full Article ROS Mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose Metabolism in Pancreatic Cancer To investigate the glycometabolism associated mechanism in invasion and metastasis of pancreatic cancer, scientists screened out genes involved in anaerobic glycolysis headed by HIF-1α,using pre-established pancreatic cancer cell lines. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSPrecision Medicine in the Management of Type 2 Diabetes In this review, investigators critically examine the progress and integration of new science into clinical practice, and review opportunities for enabling the use of precision medicine in the diagnosis and treatment of type 2 diabetes. [Lancet Diabetes Endocrinol] Abstract Immunotherapy and Prevention of Pancreatic Cancer The authors discuss promising immunotherapies currently under investigation in pancreatic cancer and provide a roadmap for the development of prevention vaccines for this and other cancers. [Trends in Cancer] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSMabVax Therapeutics to Present an Interactive Live Webcast MabVax Therapeutics Holdings, Inc., announced that David Hansen, MabVax’s President and Chief Executive Officer, will provide a corporate overview, as well as a clinical update and outline anticipated milestones for its Phase I clinical programs including the MVT-5873 clinical trial in combination with a standard of care chemotherapy as a first line therapy for patients newly diagnosed with pancreatic cancer, and the MVT-1075 radioimmunotherapy clinical trial for the treatment of pancreatic, colon and lung cancers. [Press release from MabVax Therapeutics Holdings, Inc. discussing research to be presented at VirtualInvestorConferences.com] Press Release | |
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INDUSTRY NEWSSTEMCELL Technologies Announces $45 Million Government Funding for Advanced Manufacturing Facility STEMCELL Technologies announced a $45 million joint funding agreement between the Governments of Canada and British Columbia to help the company build a state-of-the-art advanced manufacturing facility. [STEMCELL Technologies Inc.] Press Release Adocia and Tonghua Dongbao Pharmaceuticals announced a strategic partnership whereby Adocia granted exclusive development and commercialization rights to Tonghua Dongbao for the fixed-ratio insulin glargine and insulin lispro combination, BioChaperone® Combo, and ultra-rapid insulin, BioChaperone® Lispro, in China and other designated countries. [Adocia] Press Release The Janssen Pharmaceutical Companies of Johnson & Johnson announced the results of a real-world study showing that adults with type 2 diabetes initiated on INVOKANA® 300mg had significantly better blood glucose control, based on A1C goal attainment and reduction, compared to similar patients initiated on Farxiga® 10mg. [Janssen Pharmaceutical Companies of Johnson & Johnson (PR Newswire Association LLC.)] Press Release PharmaCyte Biotech, Inc., announced the successful results of long-term studies on the type of cells that will be encapsulated using its Cell-in-a-Box® technology and then combined with low doses of the cancer prodrug ifosfamide for the treatment of patients with locally advanced, non-metastatic, inoperable pancreatic cancer. [PharmaCyte Biotech Inc.] Press Release Pfizer Culls 5 Experimental Cancer Trials and an Acne Drug in Q1 Clear Out Pfizer has cleared out five early stage oncology drug tests from its pipeline, including three tests for utomilumab, as well as an acne drug. [Pfizer (Fierce Biotech)] Press Release Florida Cancer Centers Awarded $1.36 Million to Fight Pancreatic Cancer The Florida Department of Health’s James and Esther King Biomedical Research Program has armed Moffitt Cancer Center, University of Florida Health Cancer Center – Gainesville, Sylvester Comprehensive Cancer Center at the University of Miami and numerous collaborating centers with $1.36 million to address cancer disparities and improve outcomes and care for individuals affected by pancreatic cancer. [Moffitt Cancer Center] Press Release | |
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POLICY NEWSA House Too Far: Two Scientists Abandon Their Bids for Congress When Phil Janowicz and Kristopher Larsen began their campaigns for a seat in the U.S. House of Representatives, they joined what appears to be a record number of Ph.D. scientists running for national office. But after spending months on the campaign trail, the two Democrats—an organic chemistry professor from southern California and a space physics researcher from Colorado, respectively—decided to drop out before a single ballot had been cast in their states. [ScienceInsider] Editorial Disgraced Surgeon Is Still Publishing on Stem Cell Therapies Paolo Macchiarini, an Italian surgeon, has been fired from two institutions and faces the retraction of many of his papers after findings of scientific misconduct and ethical lapses in his research—yet this hasn’t prevented him from publishing again in a peer-reviewed journal. [ScienceInsider] Editorial Science in North Korea: How Easing the Nuclear Stand-Off Might Bolster Research The isolated nation publishes fewer than 100 scholarly articles a year — but as political tensions thaw, researchers hope for greater collaboration. [Nature News] Editorial Federal Appeals Court Hears CRISPR Patent Dispute A federal appeals court heard arguments that the U.S. patent office made legal mistakes when reviewing its ruling on CRISPR, the genome editor. [ScienceInsider] Editorial Harassment and Discrimination Allegations Roil a Top US Biomedical Institute Allegations of sexual harassment and assault levelled against Inder Verma, a prominent cancer biologist at the Salk Institute for Biological Studies in La Jolla, California, cap a tumultuous ten months for the well-known research centre. [Nature News] Editorial
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EVENTSNEW 6th Cambridge International Stem Cell Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Fellow – Molecular Medicine (City of Hope) Senior Clinical Research Scientist, Global Medical Affairs – Diabetes (Lilly) Doctoral Thesis Position – Endocrine Cell Research (Helmholtz Zentrum Munchen) Doctoral Thesis Position – Diabetes Research (Universite Libre de Bruxelles) Postdoctoral Fellow – Genetic Epidemiology of Metabolic Disease (University of Cambridge) Director and Biometrics Team Leader – Diabetes and Metabolic Disease (AstraZeneca) Postdoctoral Fellow – Pancreatic Cancer Research (Univeristy of South Wales) Research Fellow/Associate – Diabetes Research (Rutgers University) Postdoctoral Scholar – Cancer (University of California, San Francisco) Postdoctoral Position – Protein Biochemistry (Vlaams Instituut voor Biotechnologie) Postdoctoral Fellow – Epigenetic Regulation of Pancreatic Beta-Cell Mass (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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