Pancreatic Cell News 9.42 October 23, 2018 | |
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TOP STORYScientists explored the mechanisms inhibiting α-cell plasticity. They showed that adaptive α-cell identity changes were constrained by intra-islet insulin- and Smoothened-mediated signaling, among others. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISUsing mouse pancreatic ductal organoids, investigators saw that co-expression of Ngn3, Pdx1 and MafA were required and sufficient to generate cells that expressed insulin and resembled β-cells transcriptome-wide. [Sci Rep] Full Article Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-Cells By screening small molecules in a transgenic zebrafish model of type 1 diabetes, researchers identified inhibitors of non-canonical IκB kinases, TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε), as enhancers of β-cell regeneration. [Sci Rep] Full Article Pancreatic resident endocrine progenitors with mesenchymal stem cell phenotype were purified from BALB/c mice pancreas and characterized. [J Cell Physiol] Abstract Targeted Delivery of Antisense Oligonucleotides to Pancreatic β-Cells Researchers showed that conjugation of antisense oligonucleotides (ASOs) to a ligand of the glucagon-like peptide-1 receptor could productively deliver ASO cargo to pancreatic β-cells both in vitro and in vivo. [Sci Adv] Full Article PANCREATIC CANCERDYRK1A Modulates c-MET in Pancreatic Ductal Adenocarcinoma to Drive Tumor Growth Scientists showed that dual-specificity tyrosine regulated kinase 1A (DYRK1A) was highly expressed in pancreatic ductal adenocarcinoma, and that its protein level positively correlated with that of c-MET. [Gut] Abstract Lysine Methyltransferase 2D Regulates Pancreatic Carcinogenesis through Metabolic Reprogramming Histone lysine (K)-specific methyltransferase 2D was transcriptionally repressed in human pancreatic tumors through DNA methylation. [Gut] Abstract Researchers found that SATB-1 knockdown inhibited proliferation, migration, and invasion in SW1990 and PANC-1 cells in vitro, whereas overexpression of SATB-1 in Capan-2 and BxPC-3 cells had the opposite effect. [Cell Death Dis] Full Article Resveratrol enhanced the sensitivity of gemcitabine and inhibited lipid synthesis via sterol regulatory element binding protein 1 (SREBP1). Knockdown of SREBP1 limited the sphere formation ability and suppressed the expression of cancer stem cell markers. [Cell Prolif] Full Article Produced hyaluronic acid (HA)-decorated nanoparticles (NPs) loaded with gemcitabine and quercetin showed an improved cytotoxicity and cellular uptake toward two cell lines of pancreatic ductal adenocarcinoma, namely Mia-PaCa-2 and PANC-1, compared with both the bare drugs and the drugs loaded in NPs which did not expose HA on the surface. [J Cell Physiol] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSThe Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma The authors review the current knowledge of CDK biology, its role in cancer and the therapeutic potential to target CDKs as a novel treatment strategy for PDAC. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSBioLineRx Discloses Additional Data from Phase IIa COMBAT/KEYNOTE-202 Study in Pancreatic Cancer BioLineRx Ltd. disclosed additional data from the in-depth analyses of biopsies of the dual combination arm of the Phase IIa COMBAT/KEYNOTE-202 study, evaluating patients with metastatic pancreatic adenocarcinoma treated with BL-8040 in combination with pembrolizumab, an anti-PD-1 therapy marketed by Merck & Co., Inc. [Press release from BioLineRx Ltd. discussing research presented at the European Society for Medical Oncology (ESMO) 2018 Congress, Munich] Press Release BERG, LLC, announced the presentation of three posters on the progression of its oncology and artificial intelligence/Biomarker portfolio. [Press release from BERG, LLC (PR Newswire Association LLC) discussing research presented at the European Society for Medical Oncology (ESMO) 2018 Congress, Munich] Press Release | |
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INDUSTRY NEWSU.S. FDA Grants LYNPARZA® (Olaparib) Orphan Drug Designation for Pancreatic Cancer AstraZeneca and Merck & Co., Inc., announced that they were granted orphan drug designation by the FDA for olaparib for the treatment of pancreatic cancer. [AstraZeneca] Press Release | |
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POLICY NEWSAzar Is Empowering Anti-Fetal Tissue Research Ideologues at the Expense of Science Earlier this month, Alex Azar, secretary of the Department of Health and Human Services, visited South America, where he touted the work the United States has done to halt the spread of diseases in the region. But the same week Azar that was praising U.S.-driven health care successes abroad, he put the scientific advances of tomorrow at risk by prioritizing a far-right political ideology ahead of evidence and the health of the public. [STAT News] Editorial Cancer Research to Cut Funding for Scientists Who Bully Colleagues Britain’s largest cancer charity has announced new rules to crack down on bullying and harassment. Cancer Research UK said scientists who bullied or harassed colleagues would face sanctions that could include being prevented from supervising PhD students, losing funding from the charity or being barred from applying for future grants. [The Guardian] Editorial
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EVENTSNEW 15th Annual Stem Cell Symposium: Stem Cells B2B – Bench to Bedside Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Stem Cells and Diabetes (A*STAR) Research Technologist – Pancreatic (STEMCELL Technologies Inc.) PhD Studentship – Pancreatic Cancer (Cancer Research UK Manchester Institute) Postdoctoral Fellow – Islet Biology and Diabetes (Vanderbilt University) Postdoctoral Fellow – Epithelial Carcinogenesis (Spanish National Cancer Research Centre) Postdoctoral Fellow – Islet Biology (University of Alberta) Postdoctoral Researcher – Identifying Cell Surface Receptor (Ionis Pharmaceuticals, Inc.) Postdoctoral Position – Metabolic Inflammation in Diabetes (Inserm) Assistant Professor – Biomedical Sciences (New York Institute of Technology) Scientists – Diabetes Research (Qatar Biomedical Research Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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