Pancreatic Cell News 9.43 October 30, 2018 | |
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TOP STORYTurning Cells against Pancreatic Cancer Researchers have identified specific molecular signals released by cancer cells that determine fibroblasts’ character within pancreatic tumors. [Press release from Cold Spring Harbor Laboratory discussing online prepublication in Cancer Discovery] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISBeta-cell neogenesis was shown to be indirectly stimulated by corticosterone (CORT) since serum from CORT-treated mice increased beta-cell differentiation in in vitro cultures of pancreatic buds. [Diabetes] Abstract Insulin Secretion Depends on Intra-Islet Glucagon Signaling Researchers examined glucagon-induced insulin secretion using isolated perfused pancreata from wild-type, GLP-1 receptor knockout, diphtheria toxin-induced proglucagon knockdown, β cell-specific glucagon receptor (Gcgr) knockout, and global Gcgr knockout mice. [Cell Rep] Full Article | Graphical Abstract To elucidate the effects of Ptf1a homozygous loss, scientists prepared Elastase-CreERTM; Ptf1afloxed/floxed mice and found that homozygous Ptf1a deletion in adult acinar cells caused severe apoptosis. [Sci Rep] Full Article | Press Release PANCREATIC CANCERResearchers demonstrated that DKK3 was produced by pancreatic stellate cells and was present in most human pancreatic ductal adenocarcinoma (PDAC). DKK3 stimulates PDAC growth, metastasis, and resistance to chemotherapy with both paracrine and autocrine mechanisms through NF-κB activation. [Sci Transl Med] Abstract | Press Release Investigators showed that LZ1, a peptide derived from a snake venom cathelicidin, significantly inhibited growth of pancreatic cancer cells by inducing autophagy-dependent cell death both in vitro and in vivo. [Oncogene] Abstract Investigators performed transwell assays and wound healing assays in vitro and found that WNT7A promoted the migration capacity of cancer cells. [Sci Rep] Full Article CYLD Deficiency Promotes Pancreatic Cancer Development by Causing Mitotic Defects In pancreatic cancer samples, downregulation of cylindromatosis (CYLD) expression resulted from a loss in the copy number of the CYLD gene; additionally, reduced expression of CYLD negatively correlated with the clinicopathological parameters. [J Cell Physiol] Abstract Scientists showed that cancer associated fibroblasts stimulated indicators of pancreatic cancer malignancy, such as proliferation, invasiveness, and chemoresistance. [Cancer Sci] Full Article The expression of phosphorylated (p)-ATF-2 protein was upregulated in pancreatic cancer tissues compared with adjacent nontumorous tissues. [J Cell Biochem] Abstract Cell proliferation assay, clone formation assay, and cell apoptosis assay were performed to investigate the effects of Prx1 silencing and FOXO3 silencing on the proliferation and apoptosis ability of pancreatic cancer cells. [Cancer Manag Res] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSOptical Tools for Understanding the Complexity of β-Cell Signaling and Insulin Release Optical approaches with high resolution in space and time are extremely useful for properly deciphering the complexity of β-cell signaling. [Nat Rev Endocrinol] Abstract Mechanistic Insights into Autoimmune Pancreatitis and IgG4-Related Disease In common with other autoimmune diseases, such as systemic lupus erythematosus and psoriasis, autoimmune pancreatitis/IgG4-related disease is associated with increased type I IFN production by plasmacytoid dendritic cells. [Trends Immunol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSPharmaCyte Biotech Announces Publication of United States Patent Application for Cancer Therapies PharmaCyte Biotech, Inc. announced that its patent application titled “Encapsulated Cells Producing Cytochrome P450 and Methods of Use Thereof” was published in the United States. [PharmaCyte Biotech, Inc. (Business Wire, Inc.)] Press Release With a new $3.3 million grant, University of California School of Medicine researchers hope to create a high resolution reference map of pancreatic cells that will identify molecular changes that arise during type 1 diabetes. [University of California San Diego] Press Release | |
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POLICY NEWSDo Authors Comply When Funders Enforce Open Access to Research? Of the more than 1.3 million papers researchers identified as subject to the selected funders’ open-access mandates, researchers found that some two-thirds were indeed freely available to read. [Nature News] Editorial Australian Academics Fear Political Interference following Vetoed Projects Australian universities and researchers have condemned the actions of a government minister who vetoed projects that had been selected for funding by expert panels. Academics say that the government’s interference has undermined the integrity of the peer-review system and could damage the country’s reputation as a desirable place to do research. [Nature News] Editorial
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EVENTSNEW Gordon Research Conference: IGF and Insulin System in Physiology and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Lung and Pancreatic Cancers (University of California San Francisco) NEW Research Associate/PhD Student – Pancreatic Beta Cell Biology (Technische Universität Dresden) Research Technologist – Pancreatic (STEMCELL Technologies Inc.) Postdoctoral Position – Stem Cells and Diabetes (A*STAR) PhD Studentship – Pancreatic Cancer (Cancer Research UK Manchester Institute) Postdoctoral Fellow – Islet Biology and Diabetes (Vanderbilt University) Postdoctoral Fellow – Epithelial Carcinogenesis (Spanish National Cancer Research Centre) Postdoctoral Fellow – Islet Biology (University of Alberta) Postdoctoral Researcher – Identifying Cell Surface Receptor (Ionis Pharmaceuticals, Inc.) Postdoctoral Position – Metabolic Inflammation in Diabetes (Inserm) Assistant Professor – Biomedical Sciences (New York Institute of Technology) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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