Pancreatic Cell News Volume 9.44 | Nov 6 2018

TOP STORY

The Role of GLI-SOX2 Signaling Axis for Gemcitabine Resistance in Pancreatic Cancer

Using acquired gemcitabine resistant pancreatic cell lines, scientists revealed an important role of the GLI-SOX2 signaling axis for regulation of gemcitabine sensitivity in vitro and in animal models. [Oncogene] Full Article

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Circulating Adrenomedullin Is Elevated in Gestational Diabetes and Its Role in Impaired Insulin Production by β-Cells

The authors determined if circulating levels of adrenomedullin (ADM) in gestational diabetes mellitus women are elevated and assessed the effects of ADM on insulin synthesis and secretion by human pancreatic β-cells. [J Clin Endocrinol Metab] Abstract

Gene Signature of the Human Pancreatic ε-Cell

Scientists explored the molecular features defining the function of pancreatic ε-cells isolated from adult non-diabetic donors using single-cell RNA sequencing technology. [Endocrinology] Abstract

Comparison of Enteroendocrine Cells and Pancreatic β-Cells Using Gene Expression Profiling and Insulin Gene Methylation

Similarities between enteroendocrine cells (EECs) and β-cells were evaluated in detail. To obtain specific subtypes of EECs, cell sorting by flow cytometry was conducted from STC-1 cells, and each single cell was cultured and passaged. [PLoS One] Full Article

PANCREATIC CANCER

Direct Therapeutic Targeting of Immune Checkpoint PD-1 in Pancreatic Cancer

The authors sought to elucidate therapeutic targeting of PD-1/PD-L1. PD-1 was assessed in pancreatic cancer cells, patient-derived organoids, and clinical tissues. [Br J Cancer] Abstract

Hypoxia-Driven Paracrine Osteopontin/Integrin αvβ3 Signaling Promotes Pancreatic Cancer Cell Epithelial-Mesenchymal Transition and Cancer Stem Cell-Like Properties by Modulating FOXM1

Researchers showed that osteopontin (OPN) was highly expressed and secreted in activated pancreatic stellate cells (PSCs) driven by hypoxia, and this process was in a ROS-dependent manner; in addition, OPN was shown to be involved in the PSC-induced epithelial-mesenchymal transition and cancer stem cell-like properties of pancreatic cancer cells. [Mol Oncol] Abstract | Full Article

Dehydroabietic Oximes Halt Pancreatic Cancer Cell Growth in the G1 Phase through Induction of p27 and Downregulation of Cyclin D1

Dehydroabietic oximes inhibited the growth of human pancreatic cancer Aspc-1 cells with IC₅₀ values in the low micromolar range and showed anti-inflammatory activity, measured as the inhibition of nitric oxide production, an important inflammatory mediator in the tumor microenvironment. [Sci Rep] Full Article

Inactivation of ATF-2 Enhances Epithelial-Mesenchymal Transition and Gemcitabine Sensitivity in Human Pancreatic Cancer Cells

Investigators studied the activating transcription factor 2 or AMP-dependent transcription factor-2 inhibition mediated gemcitabine sensitivity in human pancreatic cancer cells. [J Cell Biochem] Abstract

Betulinic Acid Inhibits Stemness and EMT of Pancreatic Cancer Cells via Activation of AMPK Signaling

The authors investigated whether betulinic acid could inhibit pancreatic cancer stem cells via regulation of 5′ adenosine monophosphate‑activated protein kinase (AMPK) signaling. [Int J Oncol] Abstract

Modulation of VDR and Cell Cycle-Related Proteins by Vitamin D in Normal Pancreatic Cells and Poorly Differentiated Metastatic Pancreatic Cancer Cells

Researchers checked the effects of 1,25-dihydroxyvitamin D3 concentrations on the expression level of the vitamin D receptor (VDR) and cell cycle-related proteins CDKN1A and CDK1 in pancreatic cells and Panc-1 pancreatic cancer cells. [Nutr Cancer] Abstract

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Timing of Exposure and Bisphenol-A: Implications for Diabetes Development

The authors comment and discuss the contributing role of bisphenol-A (BPA) in the etiology of diabetes. They address the metabolic consequences of BPA exposure at different stages of life and comment on the final phenotype observed in different whole-animal models of study. [Front Endocrinol] Full Article

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Bavarian Nordic Announces Initiation of Clinical Trial Evaluating the Combination Therapy of CV301 and Durvalumab in Metastatic Colorectal and Pancreatic Cancers

Bavarian Nordic A/S announced that the first patient has been dosed in a clinical study evaluating CV301, the company’s targeted immunotherapy candidate, and durvalumab, AstraZeneca’s PD-L1 inhibitor, in combination with maintenance chemotherapy for patients with metastatic colorectal or pancreatic cancers. [Bavarian Nordic] Press Release

Helix BioPharma Corp. to Initiate New L-DOS47 Clinical Program in Pancreatic Cancer

Helix BioPharma Corp. announced that it will initiate a new clinical program in pancreatic cancer which will be led by Dr. Daniel D. Von Hoff. [Helix BioPharma Corp. (GlobeNewswire, Inc.)] Press Release

PharmaCyte Biotech Selects Medpace as CRO for Its Clinical Trial in Pancreatic Cancer

PharmaCyte Biotech, Inc. announced that it has selected Medpace, Inc. as the Contract Research Organization (CRO) to conduct PharmaCyte’s clinical trial in locally advanced, non-metastatic, inoperable pancreatic cancer. [PharmaCyte Biotech, Inc.] Press Release

Wellcome and Gates Join Bold European Open-Access Plan

Two of the world’s largest biomedical research funders have backed a plan to make all papers resulting from work they fund open access on publication by 2020. On 5 November, the London-based Wellcome Trust and the Bill and Melinda Gates Foundation in Seattle, Washington, announced they were both endorsing ‘Plan S’, adding their weight to an initiative already backed by 13 research funders across Europe since its launch in September. [Nature News] Editorial

NSF Suspends Program Allowing Graduate Fellows to Study Abroad

The U.S. National Science Foundation (NSF) has halted a program that each year allows hundreds of the nation’s best graduate students to work with experts in another country. And the agency isn’t saying why—or whether the program will resume. [ScienceInsider] Editorial

Record Number of Monkeys Being Used in U.S. Research

The number of monkeys used in U.S. biomedical research reached an all-time high last year, according to data released in late September by the United States Department of Agriculture. [ScienceInsider] Editorial

Drug Companies Try to Catch the Rising Wave of RNAi Medicines

Less than two months after the FDA approved the first-ever drug that uses a Nobel-winning technique to mute disease-causing genes, the pharmaceutical industry is already looking for a piece of the next one. [STAT News] Editorial

NEW Defence Is the Best Attack: Immuno-Oncology Breakthroughs
March 11-13, 2019
Barcelona, Spain

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NEW Bench Research Fellowship – Cardiovascular Disease (Brigham & Women’s Hospital – Harvard Medical School)

Research Technologist – Pancreatic (STEMCELL Technologies Inc.)

Postdoctoral Position – Lung and Pancreatic Cancers (University of California San Francisco)

Research Associate/PhD Student – Pancreatic Beta Cell Biology (Technische Universität Dresden)

Postdoctoral Position – Stem Cells and Diabetes (A*STAR)

PhD Studentship – Pancreatic Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Fellow – Islet Biology and Diabetes (Vanderbilt University)

Postdoctoral Fellow – Epithelial Carcinogenesis (Spanish National Cancer Research Centre)

Postdoctoral Fellow – Islet Biology (University of Alberta)

Postdoctoral Researcher – Identifying Cell Surface Receptor (Ionis Pharmaceuticals, Inc.)

Postdoctoral Position – Metabolic Inflammation in Diabetes (Inserm)

Postdoctoral Position – Inflammation and Metabolism (Sanford Burnham Prebys Medical Discovery Institute)

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