Pancreatic Cell News 9.47 November 27, 2018 | |
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TOP STORYScientists found that collagen fiber deposition was increased and fibronectin fibril orientation was drastically remodeled by pancreatic stellate cells, but not normal fibroblasts, in a manner dependent on transforming growth factor-β/Rho-associated kinase signaling and matrix metalloproteinase activity. [Biomaterials] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISQuantitative Proteomics Evaluation of Human Multipotent Stromal Cell for β Cell Regeneration A high-throughput quantitative proteomics assay was developed to screen β cell regenerative potency of donor-derived human multipotent stromal cells lines. [Cell Rep] Full Article | Graphical Abstract Investigators examined the effects of irisin on lipid metabolism and inflammation in β cells under glucolipotoxic conditions. Rat INS-1E β cells and islets isolated from C57BL/6 mice were incubated in glucolipotoxic conditions with or without irisin. [Cell Physiol Biochem] Full Article The authors hypothesised that media conditioned by contracting skeletal muscle would influence insulin secretion and mitochondrial energy metabolism in β-cells under normal and type-2 diabetic conditions. [Metabolism] Abstract PANCREATIC CANCERInvestigators demonstrated surface relocalization and survival signaling by cleft lip and palate transmembrane 1‐like (CLPTM1L) triggered by endoplasmic reticular (ER) stress. [Int J Cancer] Abstract miR-21 Promotes EGF-Induced Pancreatic Cancer Cell Proliferation by Targeting Spry2 Scientists demonstrated that miR-21 expression was induced by epidermal growth factor (EGF) in pancreatic cancer cells. miR-21 promoted EGF-induced proliferation, inhibited cell apoptosis and accelerated cell cycle progression. [Cell Death Dis] Full Article miR-222 was identified by miRNA microarray studies in exosomes of pancreatic ductal adenocarcinoma (PDAC) cells, and further analyzed in plasma exosomes of PDAC patients. The regulatory mechanisms of miR-222 were explored by qRT-PCR, WB, dual-luciferase assays and immunofluorescence or confocal analysis. [Cell Physiol Biochem] Full Article Researchers investigated the effects of cantharidin on pancreatic cancer xenografts in vivo. Xenograft models were established using cells stably expressing luciferase. [Oncogenesis] Full Article Inhibition of glycosylation decreased growth and cancer stem cells (CSCs)/side population in pancreatic cancer cells. Pancreatic CSCs overexpressed CSC markers, exhibited global expressional variation of tumor-associated carbohydrate antigens and showed higher self-renewal potential. [BMC Cancer] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSContribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes Type 2 diabetes development involves multiple changes in β-cells, related to the oxidative stress and impaired redox signaling, beginning frequently by sustained overfeeding due to the resulting lipotoxicity and glucotoxicity. Uncovering relations among the dysregulated metabolism, impaired β-cell “well being”, biogenesis, or crosstalk with peripheral insulin resistance is required for elucidation of type 2 diabetes etiology. [Antioxid Redox Signal] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSStand Up to Cancer Funds Innovative Approach to Pancreatic Cancer Research on a new way of deploying the immune system against pancreatic cancer, an exceptionally lethal cancer that has so far resisted new immunotherapies, will receive $1 million in initial funding from Stand Up to Cancer. [The University of Texas MD Anderson Cancer Center] Press Release OSE Immunotherapeutics SA announced that the French National Agency for Medicines and Health Products Safety and the French Central Ethic Committee approved the initiation of a new Phase II trial evaluating Tedopi®, a combination of neoepitopes, in combination with Bristol-Myers Squibb’s Opdivo®, an immune checkpoint inhibitor, versus Folfiri in advanced or metastatic pancreatic cancer. [OSE Immunotherapeutics SA] Press Release Halozyme Announces Change in Primary Endpoint for HALO-301 to Overall Survival Halozyme Therapeutics, Inc. announced that prior to data analysis, the FDA has agreed to Halozyme’s request to change the primary endpoint of the HALO-301 study to the single primary endpoint of overall survival. [Halozyme Therapeutics, Inc.] Press Release | |
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POLICY NEWSBiomedical Research Is Becoming More Open about Its Funding and Data Biomedical research is shifting to become more open and transparent by providing increasing amounts of information about funding, conflicts of interest and data sharing in their publications, according to a survey of recent papers. [Nature News] Editorial European Funders Detail Their Open-Access Plan Plan S, the contentious plan that a group of European science funders hopes will end scholarly journals’ paywalls, has fleshed out its rules—and softened its tone a bit. In seven pages of implementation guidance released, the funders explain how their grantees can abide by Plan S rules come 2020, when it goes into effect. But some critics say the document—which is up for public discussion for the next two months—remains too restrictive. [ScienceInsider] Editorial Crashing the Boards: Neuroscientist Maureen Condic Brings a Different Voice to NSF Oversight Body The National Science Foundation (NSF) will welcome the first cohort of members appointed by President Donald Trump to its oversight body, the National Science Board. Most of the seven fit the mold of senior academic leaders, prominent scientists, and corporate research managers who typically sit on the 24-member board. But Maureen Condic is somewhat different. [ScienceInsider] Editorial A 100th Birthday Wish: Uphold Academic Freedom in Dark Times One hundred years ago this month, shortly after the guns of the First World War fell silent, a German-speaking Scottish lawyer-turned-politician sent an 80-page report to his prime minister. In it was an idea whose echo still shapes the way in which many nations fund research — an idea arguably as important to the soul of modern science as the secular state is to modern democracy. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Cancer Metastasis: The Role of Metabolism, Immunity and the Microenviroment Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Organ on a Chip Microfluidic Platform Design (University of Oslo) Research Technologist – Pancreatic Cell Research (STEMCELL Technologies Inc.) Computational Biologist – Translational Cancer Research (Technical University of Munich) Research Lab Specialist – Cancer Biology (University of Southern California) Postdoctoral Position – Pancreatic Cancer (University Hospitals) PhD Positions – Cancer Biology (Technical University of Munich) Postdoctoral Position – Lung and Pancreatic Cancers (University of California San Francisco) Postdoctoral Position – Stem Cells and Diabetes (A*STAR) PhD Studentship – Pancreatic Cancer (Cancer Research UK Manchester Institute) Postdoctoral Fellow – Epithelial Carcinogenesis (Spanish National Cancer Research Centre) Postdoctoral Fellow – Islet Biology (University of Alberta) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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